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Molecules, Volume 5, Issue 12 (December 2000) – 54 articles , Pages 1187-1532, Articles M172-M192

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1 pages, 90 KiB  
Short Note
8,9-24,25-Diepoxy-Eupho-lanostan-3,4-olactone
by N. El Aouad 1,*, A. Benharref 1 and J.-P. Lavergne 2
1 Laboratoire de Chimie des Substances Naturelles et des Hétérocycles, Université Cadi Ayaad, Faculté des Sciences Semlalia, Marrakech. Maroc
2 Laboratoire des Aminoacides, Peptides et Protéines, Université Montpellier II, 34095- Montpellier cedex 5. France
Molecules 2000, 5(12), M172; https://doi.org/10.3390/M172 - 25 Dec 2000
Viewed by 3359
Abstract
To a mixture of 0.8 g (4.7 mmol) of metachloroperbenzoique acid (mCPBA) and 1.58g (18.8mmol) of sodium hydrogenocarbonate (NaHCO3) in 15 ml of dichloromethane was added 1 g (2.35 mmol) of 1 in 5 ml of CH2Cl2.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
2 pages, 95 KiB  
Short Note
5-[o-(1-L-Phenylalanylamino)ethoxyl]phenyl-10,15,20-triphenylporphyrin
by Hai-yang Liu 1,*, Xi-ming Hu 1,*, Xiao Ying 2, Zhong-ping Yao 3, Jin-wang Huang 1 and Liang-nian Ji 4,*
1 Department of Applied Chemistry, South China University of technology, Guangzhou 510641, China
2 Department of Physics, South China University of technology, Guangzhou 510641, China
3 Department of Chemistry, Hong Kong University of Science and Technology, Hong Kong, China
4 Department of Chemistry, Zhongshan University, Guangzhou 510275, China
Molecules 2000, 5(12), M173; https://doi.org/10.3390/M173 - 25 Dec 2000
Cited by 3 | Viewed by 4817
Abstract
5-[o-(2-bromo-1-ethoxy)]phenyl-10,15,20-triphenylporphyrin (1) was prepared according to published method [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
1 pages, 88 KiB  
Short Note
3-Chloro-5-methoxy-1-benzo[b]thiophene-2-sulphonamide
by Gerard P. Moloney
Department of Medicinal Chemistry, Victorian College of Pharmacy (Monash University) 381 Royal Parade Parkville Vic 3052 Australia
Molecules 2000, 5(12), M174; https://doi.org/10.3390/M174 - 25 Dec 2000
Viewed by 3318
Abstract
As part of a research programme targeting novel molecules as potential anti-inflammatory agents we synthesised 3-Chloro-5-methoxy-1-benzo[b]thiophene-2-sulphonylamide base on the reported anti-inflammatory activity of the structurally related molecule 3-Isopropoxy-5-methoxy-N-(1H-1,2,3,4-tetraazol-5-yl)-1-benzothiophene-2-carboxamide [1,2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
2 pages, 90 KiB  
Short Note
2,4-Dinitrophenylhydrazine-benzo-9-crown-3
by A. Moghimi 1,*, M. Faal Rastegar 2 and M. Ghandi 2
1 Department of Chemistry, University of Imam Hosien, Tehran, Iran
2 Deparment of Chemistry, Faculty of Science, University of Tehran, Tehran, Iran
Molecules 2000, 5(12), M175; https://doi.org/10.3390/M175 - 25 Dec 2000
Cited by 1 | Viewed by 3872
Abstract
In the course of our recent studies on the synthesis, solid phase structure, solution and solid phase 13C CPMAS [1], and its application in Ion Selective Electrodes [2] of the smallest benzo crown ether, Benzo-9-Crown-3, B9C3, we accomplished the synthesis of B9C3 [...] Read more.
In the course of our recent studies on the synthesis, solid phase structure, solution and solid phase 13C CPMAS [1], and its application in Ion Selective Electrodes [2] of the smallest benzo crown ether, Benzo-9-Crown-3, B9C3, we accomplished the synthesis of B9C3 derivative 3.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
2 pages, 89 KiB  
Short Note
(u,l,l,u)-3,5-Diethyl-2,4,6-triphenyltetrahydropyran-2,4-diol
by Rolf Söllner 1, Thomas Koy 2 and Michael Schmittel 2,*
1 Institut für Organische Chemie der Universität Würzburg, Am Hubland, 97074 Würzburg, Germany
2 FB 8 - OC 1 (Chemie - Biologie), Universität GH Siegen, Adolf-Reichwein-Str., D-57068 Siegen, Germany
Molecules 2000, 5(12), M176; https://doi.org/10.3390/M176 - 25 Dec 2000
Viewed by 4605
Abstract
The experimental procedure follows a novel protocol developed recently by us [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
1 pages, 89 KiB  
Short Note
2-(4-Biphenyl-1-yl)-1,3-diazaspiro[4,5]dec-1-en-4-thione
by Milos Sedlak * and Jirí Hanusek
Department of Organic Chemistry, University of Pardubice, Cs Legii 565, 523 10 Pardubice, Czech Republic
Molecules 2000, 5(12), M177; https://doi.org/10.3390/M177 - 25 Dec 2000
Cited by 5 | Viewed by 2918
Abstract
The title compound was prepared from imidazolinone 1 whose synthesis as well as 1H and 13C NMR spectra were published previously [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
2 pages, 90 KiB  
Short Note
2-Carbomethoxynor-31-lanosten-2-enol
by M. Daoubi 1,*, A. Benharref 1 and M. Pierrot 2
1 Laboratoire de Chimie des Substances Naturelles et des Hétérocycles, Université Cadi Ayyad, Faculté des Sciences Semlalia, BP 2390. Bd Prince My Abdellah, Marrakech. Maroc
2 LBS-UMR 6517, Centre Scientifique Saint-Jérôme, 13397 Marseille, CEDEX 20, France
Molecules 2000, 5(12), M178; https://doi.org/10.3390/M178 - 25 Dec 2000
Cited by 1 | Viewed by 3732
Abstract
To sodium hydride (0.3g, 12.7 mmole) carefully washed with anhydrous benzene under nitrogen (to eliminate mineral oil from the commercial product) [1], was added (0.8 ml, 8.43 mmole) of dimethylcarbonate (freshly distilled) in dry benzene (20 ml).[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
2 pages, 200 KiB  
Short Note
bis[(N-Benzyloxycarbonyl)-(2R)-amino-4-methylpentyl]disulfide
by Jean-Marc Poudrel and Peter Karuso *
Department of Chemistry, Macquarie University, NSW 2109 Sydney, Australia
Molecules 2000, 5(12), M179; https://doi.org/10.3390/M179 - 25 Dec 2000
Viewed by 3689
Abstract
Disulfides that mimic the pentapeptide Phe-D-Leu-Gly-D-Leu-Phe can be obtained in high yield from the corresponding thioacetate via the intermediate mercaptan by prolonged standing in alkali [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
2 pages, 90 KiB  
Short Note
bis[(N-Benzyloxycarbonyl)-(2S)-amino-4-methylpentyl]disulfide
by Jean-Marc Poudrel and Peter Karuso *
Department of Chemistry, Macquarie University, NSW 2109 Sydney, Australia
Molecules 2000, 5(12), M180; https://doi.org/10.3390/M180 - 25 Dec 2000
Viewed by 3178
Abstract
Disulfides that mimic the pentapeptide Phe-Leu-Gly-Leu-Phe can be obtained in high yield from the corresponding thioacetate via the intermediate mercaptan by prolonged standing in alkali [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
2 pages, 94 KiB  
Short Note
A New Xanthone from Swertia decora
by Huai Xiao 1, Zenai Chen 1, Guangming Liu 2, Jinfu Qian 2 and Yang Lu 1,*
1 Department of Chemistry, Shanghai Second Medical University, Shanghai200025, People's Republic of China
2 Department of Pharmacy, Dali Medical College, Dali, Yunnan Province-671000, People's Republic of China
Molecules 2000, 5(12), M181; https://doi.org/10.3390/M181 - 25 Dec 2000
Cited by 3 | Viewed by 4971
Abstract
Members of genus Swertia (Gentianaceae) have been the source of many active xanthones.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
1 pages, 89 KiB  
Short Note
N-Benzotriazol-1-yl-methyl-1,2,3,4-tetrahydro-b-carboline
by Ann Lam and Naseem Peerzada
Faculty of Science, Information Technology and Education, Northern Territory University, Darwin, N.T. 0909, Australia
Molecules 2000, 5(12), M182; https://doi.org/10.3390/M182 - 25 Dec 2000
Viewed by 3871
Abstract
Katritzky's well-established chemistry of benzotriazole [1] was applied to the synthesis of 1,2,3,4- tetrahydro-b-carboline, which have been traditionally prepared by Pictet-Spengler condensation2, Fischer cyclisation and other methods3.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
1 pages, 87 KiB  
Short Note
5-(Indol-3-yl)barbituric acid
by Abdullah Mohamed Asiri
Chemistry Department, Faculty of Science, King Abdul-Aziz University, Jeddah 21589, P. B. Box 80203, Saudi Arabia
Molecules 2000, 5(12), M183; https://doi.org/10.3390/M183 - 25 Dec 2000
Cited by 2 | Viewed by 4637
Abstract
5-(Indol-3-yl)barbituric acid 3 was prepared by knovenagel condensation of indol-3-carboxaldehyde 1 and barbituric acid 2 in ethanol using piperidine as a base [1,2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
1 pages, 84 KiB  
Short Note
E-(4-Methylbenzylidene)succinic anhydride
by Abdullah Mohamed Asiri
Chemistry Department, Faculty of Science, King abdul-Aziz University, Jeddah 21589, P. B. Box 80203, Saudi Arabia
Molecules 2000, 5(12), M184; https://doi.org/10.3390/M184 - 25 Dec 2000
Viewed by 3906
Abstract
The title compound was obtained by dehydration of the corresponding diacid 1 (12.1 g, 55 mmol) by boiling in acetyl chloride (50 ml) for four hours.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
1 pages, 88 KiB  
Short Note
1,4-Bis(2',4',6'-trimethylphenylethynyl)benzene
by Laura Jeffries and Eric Bosch *
Chemistry Department, Southwest Missouri State University, 901 South National Avenue, Springfield MO 65804, USA
Molecules 2000, 5(12), M185; https://doi.org/10.3390/M185 - 25 Dec 2000
Viewed by 2926
Abstract
The experimental procedure follows the general synthesis of arylalkynes reported by Sonogashira [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
1 pages, 89 KiB  
Short Note
2-Methyl-5-methylmercapto-3-dimethylsulfoxymethine-7-phenyl-1,2,4-triazepine
by My. Y. Ait Itto 1, A Hasnaoui 1, A. Riahi 2 and A. Huet 3,*
1 Laboratoire de chimie des substances naturelles et des Hétérocycles, Département de Chimie, Faculté des Sciences Semlalia, B.P. 2390, 40001 Marrakech-Maroc
2 Université de Reims, UFR Sciences, UMR N° 6519, Réactions Sélectives et Applications, B.P. 1039, 51687 Reims Cedex 2 France. 3Laboratoire de Synthèse Organique, Université de Maine, Le Mans-France
3 Laboratoire de Synthèse Organique, Université de Maine, Le Mans-France
Molecules 2000, 5(12), M186; https://doi.org/10.3390/M186 - 25 Dec 2000
Cited by 3 | Viewed by 3541
Abstract
All the following operations were performed under an inert atmosphere using standard vacuum line techniques. Trimethyloxosulfonium iodide (2, 0.73 g, 3.3 mmol) [1] was suspended in anhydrous DMSO (6 mL) and sodium hydride (80 % suspension in mineral oil, 0.1 g, [...] Read more.
All the following operations were performed under an inert atmosphere using standard vacuum line techniques. Trimethyloxosulfonium iodide (2, 0.73 g, 3.3 mmol) [1] was suspended in anhydrous DMSO (6 mL) and sodium hydride (80 % suspension in mineral oil, 0.1 g, 3.3 mmol) was added at room temperature.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
1 pages, 91 KiB  
Short Note
8a,9a-Epoxy Nor-31-lanosten-3-one
by M. Daoubi 1,*, A. Benharref 1, E. Kossareva 2 and M. Pierrot 2
1 Laboratoire de Chimie des Substances Naturelles et Hétérocycles, Université Cadi Ayyad, Faculté des Sciences Semlalia, B.P : 2390, Marrakech. Maroc
2 LBS-UMR 6517, Centre Scientifique Saint-jérôme, 13397 Marseille, CEDEX 20, France
Molecules 2000, 5(12), M187; https://doi.org/10.3390/M187 - 25 Dec 2000
Viewed by 3379
Abstract
To the epoxide 1 (1 g, 2.32 mmol) in acetone (50 ml) [1] was added dropwise at 0°C a solution of CrO3 (0.7 g, 7 mmol) in acetone (20 ml).[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
1 pages, 92 KiB  
Short Note
8a,9a-Epoxy Nor-31-lanosten-3,4-olactone
by M. Daoubi 1,*, A. Benharref 1, E. Kossareva 2 and M. Pierrot 2
1 Laboratoire de Chimie des Substances Naturelles et Hétérocycles, Université Cadi Ayyad, Faculté des Sciences Semlalia, B.P : 2390, Marrakech. Maroc
2 LBS-UMR 6517, Centre Scientifique Saint-jérôme, 13397 Marseille, CEDEX 20, France
Molecules 2000, 5(12), M188; https://doi.org/10.3390/M188 - 25 Dec 2000
Cited by 2 | Viewed by 3491
Abstract
To a mixture of (0.85 g, 4.9 mmol) of metachloroperoxybenzoic acid (mCPBA) [1,2] and (1.63 g, 19.6 mmol) of sodium hydrogenocarbonate (NaHCO3) in 20 ml of dichloromethane was added (1 g, 2.42 mmol) of 1 in 10 ml of CH2Cl2.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
1 pages, 92 KiB  
Short Note
2-Carbomethoxy-8a,9a-epoxy Nor-31-lanosten-3-enol
by M. Daoubi 1,*, A. Benharref 1, A. Kenz 2 and M. Pierrot 2
1 Laboratoire de Chimie des Substances Naturelles et Hétérocycles, Université Cadi Ayyad, Faculté des Sciences Semlalia, B.P : 2390, Marrakech. Maroc
2 LBS-UMR 6517, Centre Scientifique Saint-jérôme, 13397 Marseille, CEDEX 20, France
Molecules 2000, 5(12), M189; https://doi.org/10.3390/M189 - 25 Dec 2000
Viewed by 3428
Abstract
To sodium hydride (0.34 g, 13.96 mmole) carefully washed with anhydrous benzene under nitrogen (to eliminate mineral oil from the commercial product) [1], was added 0.8 ml (9.27 mmol) of dimethylcarbonate (freshly distilled) in dry benzene (20 ml).[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
1 pages, 86 KiB  
Short Note
8-Dihydro-3-methyl-7-amino-[1,2,4]triazino[3,4-b][1,3,4]thiadiazine
by Majid M. Heravi 1,3,*, Ghadir Rajabzadeh 1, Mohammad Rahimizadeh 1, Mehdi Bakavoli 1 and Mitra Ghassemzadeh 2
1 Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, Iran. Department of Chemistry
2 Chemistry & Chemical Engineering Research Center of Iran, P.O.Box 14335-186, Tehran, Iran
3 Present address : School of Sciences, Azzahra University, Vanak, Tehran, Iran
Molecules 2000, 5(12), M190; https://doi.org/10.3390/M190 - 25 Dec 2000
Viewed by 3627
Abstract
8-Dihydro-3-methyl-7-amino-[1,2,4]triazino[3,4-b][1,3,4]thiadiazine 2 was prepared by the cyclocondensation of 4-amino-6-methyl-3-thio-1,2,4-triazin-5-one 1 with chloro-acetonitrile in the presence of triethylamine in refluxing CH3CN.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
1 pages, 92 KiB  
Short Note
E,E-1-(4-Bromophenyl)-5-(3-indolyl)-1,4-pentadien-3-one
by Gang-Chun Sun 1, Rui-Yun Guo 2, Jian-Qiang Qu 1, Liu-Fang Wang 1,*, Jun-Biao Chang 2,* and Rong-Feng Chen 2
1 National Key Laboratory of Applied Chemistry, Lanzhou University, Lanzhou 730000, P.R.China
2 Henan Institute of Chemistry, Zhengzhou 450002, P.R.China
Molecules 2000, 5(12), M191; https://doi.org/10.3390/M191 - 25 Dec 2000
Viewed by 4693
Abstract
3-(1-Butenone-3)indole 1 was prepared by previously published method [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
1 pages, 87 KiB  
Short Note
24,31-Epoxy-24-methyl-elemo-lanost-8,9-ene-3-ol
by N. El Aouad 1, A. Benharref 1 and R. Gree 2,*
1 Laboratoire de Chimie des Substances Naturelles et des Hétérocycles, Université Cadi Ayyad, Faculté des Sciences Semlalia. BP 2390 Boulevard Prince My Abdellah. Marrakech, Maroc
2 Laboratoire de Chimie de Synthèses et Activations de Biomolécules, Ecole Nationale Supérieure de Chimie de Rennes. Avenue du Général Leclerc 35700 Rennes, France
Molecules 2000, 5(12), M192; https://doi.org/10.3390/M192 - 25 Dec 2000
Viewed by 3840
Abstract
To a solution of 1g (2.27 mmol) of 1 in 40ml of chloroform at room temperature was added 0.55g (2.27 mmol) of meta-chloroperbenzoic acid (mCPBA).[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
7 pages, 59 KiB  
Article
Synthesis of 1-(2'-Deoxy-ß-D-ribofuranosyl)-1H-imidazo[4,5-d]-pyridazine-4,7(5H,6H)-dione: A Potential Building Block for Antisense Applications
by Huan-Ming Chen and Ramachandra S. Hosmane *
Laboratory for Drug Design and Synthesis, Department of Chemistry & Biochemistry, University of Maryland, Baltimore County (UMBC), 1000 Hilltop Circle, Baltimore, Maryland 21250, USA
Molecules 2000, 5(12), 1187-1193; https://doi.org/10.3390/51201187 - 15 Dec 2000
Cited by 8 | Viewed by 6883
Abstract
Synthesis of the title compound,1-(2'-deoxy-b-D-ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7(5H,6H)-dione (1), is reported. It was synthesized in five steps, commencing with methyl 1-(b-D-ribofuranosyl)imidazo-4,5-dicarboxylate (2). The 3',5'-hydroxyl groups of 2 were protected with a bis-silylating agent to form 3, which was then converted into the corresponding 2'-thionocarbonate derivative 5. [...] Read more.
Synthesis of the title compound,1-(2'-deoxy-b-D-ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7(5H,6H)-dione (1), is reported. It was synthesized in five steps, commencing with methyl 1-(b-D-ribofuranosyl)imidazo-4,5-dicarboxylate (2). The 3',5'-hydroxyl groups of 2 were protected with a bis-silylating agent to form 3, which was then converted into the corresponding 2'-thionocarbonate derivative 5. The reduction of the latter with tri-n-butyltin hydride (to form 6), followed by silyl deprotection with tetra-nbutylammonium fluoride, afforded 7. Treatment of the latter with hydrazine hydrate yielded the target nucleoside 1. Full article
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Scheme 1

7 pages, 93 KiB  
Article
Synthesis Of Some Novel Silver-Cysteamine Complexes
by Davood Habibi *, Ezat Ghaemi and Davood Nematollahi
Chem. Dept., Science Faculty, Bu-Ali-Sina University, Hamadan, Iran
Molecules 2000, 5(12), 1194-1200; https://doi.org/10.3390/51201194 - 15 Dec 2000
Cited by 8 | Viewed by 7341
Abstract
The aim of this research was to synthesize some new silver-cysteamine complexes of potential biological interest. Reactions were carried out between silver nitrate and cysteamine (2-aminoethanethiol hydrochloride) under different conditions of pH and mole ratios of the metal (silver) to the ligand (cysteamine). [...] Read more.
The aim of this research was to synthesize some new silver-cysteamine complexes of potential biological interest. Reactions were carried out between silver nitrate and cysteamine (2-aminoethanethiol hydrochloride) under different conditions of pH and mole ratios of the metal (silver) to the ligand (cysteamine). Some novel silver-cysteamine complexes were made, and after characterization of the complexes by cyclic voltammetry, pH measurements, and microanalysis, it is now obvious that the mole ratio of the metal to the ligand in complexes is about four to three. Full article
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Figure 1

9 pages, 78 KiB  
Review
Synthesis of Jasmonoides from Furan Derivatives
by Janusz Nowicki
Institute of Heavy Organic Synthesis "Blachownia", ul. Energetyków 9, 47-225 Kędzierzyn-Koźle Poland
Molecules 2000, 5(12), 1201-1209; https://doi.org/10.3390/51201201 - 15 Dec 2000
Cited by 2 | Viewed by 9964
Abstract
This paper presents applicability of commonly available furan derivatives, like 2-methyl furan, furaldehyde and 5-methylfuraldehyde in syntheses of jasmanoides. Full article
►▼ Show Figures

Scheme 1

14 pages, 260 KiB  
Article
Regioselectivity of Electrophilic Attack on 4-Methyl-1-Thioxo-1,2,4,5-Tetrahydro[1,2,4]Triazolo[4,3-A]Quinazolin-5-One Part 2: Reactions on Nitrogen Atom
by W. Fathalla 1, M. ÄŒajan 1,2 and P. Pazdera 1,*
1 Department of Organic Chemistry, Faculty of Science, Masaryk University, Brno, Czech Republic
2 Laboratory of Biomolecular Structure and Dynamics, Faculty of Science, Masaryk University, Brno, Czech Republic
Molecules 2000, 5(12), 1210-1223; https://doi.org/10.3390/51201210 - 15 Dec 2000
Cited by 27 | Viewed by 7866
Abstract
The regioselectivity on a cyclic thioamide group towards different electrophiles was studied on the model compound 4-methyl-1-thioxo-1,2,4,5-tetrahydro[1,2,4]triazolo [4,3-a]quinazolin-5-one 1. The examined compound 1 reacts with alkyl halides, amines in the presence of formaldehyde, acyl halides and compounds having activated double bonds to afford [...] Read more.
The regioselectivity on a cyclic thioamide group towards different electrophiles was studied on the model compound 4-methyl-1-thioxo-1,2,4,5-tetrahydro[1,2,4]triazolo [4,3-a]quinazolin-5-one 1. The examined compound 1 reacts with alkyl halides, amines in the presence of formaldehyde, acyl halides and compounds having activated double bonds to afford the N-substituted derivatives 2, 3 and 6. The regioselective reactions on nitrogen atom are due to strong Coulombic attraction. The reaction of 1 with amines in the presence of hydrogen peroxide afforded the aminolysis product 4. Compounds 1-6 were identified by FTIR, 1H NMR, 13C NMR, and mass spectroscopy. Full article
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Figure 1

16 pages, 165 KiB  
Article
Chemistry of Substituted Quinolinones. Part VI. Synthesis and Nucleophilic Reactions of 4-Chloro-8-methylquinolin-2(1H)-one and its Thione Analogue
by Mostafa M. Ismail, Mohamed Abass * and Mohamed M. Hassan
Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711 Cairo, Egypt
Molecules 2000, 5(12), 1224-1239; https://doi.org/10.3390/51201224 - 18 Dec 2000
Cited by 34 | Viewed by 13995
Abstract
The synthesis of 4-chloro-8-methylquinolin-2(1H)-one and its thione analogue is described. Some nucleophilic substitution reactions of the 4-chloro group were carried out to get new 4-substituted 2-quinolinones and quinolinethiones, such as 4-sulfanyl, hydrazino, azido and amino derivatives, which are of important synthetic [...] Read more.
The synthesis of 4-chloro-8-methylquinolin-2(1H)-one and its thione analogue is described. Some nucleophilic substitution reactions of the 4-chloro group were carried out to get new 4-substituted 2-quinolinones and quinolinethiones, such as 4-sulfanyl, hydrazino, azido and amino derivatives, which are of important synthetic use. The structure of the new compounds was established by their elemental analysis, IR and 1H-NMR spectra. Also the mass fragmentation pattern of some products is discussed. Full article
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4 pages, 31 KiB  
Article
An Efficient Synthesis of 5-Alkoxycarbonyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones Catalyzed by KSF Montmorillonite
by Haixia Lin 1,*, Jinchang Ding 1, Xianten Chen 1 and Ziyi Zhang 2
1 Department of Chemistry, Wenzhou Normal College, Wenzhou 325003, China
2 Department of Chemistry, Lanzhou University, Lanzhou 730000, China
Molecules 2000, 5(12), 1240-1243; https://doi.org/10.3390/51201240 - 18 Dec 2000
Cited by 49 | Viewed by 6205
Abstract
A mild and efficient catalytic method for synthesis of 5-alkoxycarbonyl-4-aryl-3,4- dihydropyrimidin-2(1H)-ones using KSF montmorillonite as catalyst is described. Full article
7 pages, 68 KiB  
Article
Improvement of a Critical Intermediate Step in the Synthesis of a Nitroxide-Based Spin-Labeled Deoxythymidine Analog
by Jeannine H. Powell, Edward M. Johnson II and Peter M. Gannett *
Department of Basic Pharmaceutical Sciences, West Virginia University School of Pharmacy, P. O. Box 9530, Morgantown, West Virginia, USA
Molecules 2000, 5(12), 1244-1250; https://doi.org/10.3390/51201244 - 18 Dec 2000
Cited by 12 | Viewed by 7967
Abstract
Methods to reduce the carboxylic acid moiety in 3-carboxy-2,2,5,5-tetramethylpyrrolin-1-oxyl to an alcohol as an intermediate toward the corresponding aldehyde have been explored and an improved method has been developed. Full article
8 pages, 43 KiB  
Article
Facile and Stereoselective Synthesis of Non-Racemic 3,3,3-Trifluoroalanine
by Marcello Crucianelli 1,*, Natalia Battista 1, Pierfrancesco Bravo 2,3, Alessandro Volonterio 2 and Matteo Zanda 2,*
1 Dipartimento di Chimica, Ingegneria Chimica e Materiali, Università di L'Aquila, Via Vetoio, I-67010 Coppito, Italy
2 Dipartimento di Chimica del Politecnico, via Mancinelli 7, I-20131 Milano, Italy
3 C.N.R. - Centro di Studio sulle Sostanze Organiche Naturali, via Mancinelli 7, I-20131 Milano, Italy
Molecules 2000, 5(12), 1251-1258; https://doi.org/10.3390/51201251 - 18 Dec 2000
Cited by 11 | Viewed by 7613
Abstract
A highly stereoselective enantiodivergent synthesis of non-racemic 3,3,3-trifluoroalanine 7 is reported. The methodology is based on the reduction, by 9-BBN or DIBAH, of the chiral sulfinimine 3 derived from ethyl trifluoropyruvate, followed by acidic hydrolysis of the resulting diastereomeric sulfinamides 4 and 5. [...] Read more.
A highly stereoselective enantiodivergent synthesis of non-racemic 3,3,3-trifluoroalanine 7 is reported. The methodology is based on the reduction, by 9-BBN or DIBAH, of the chiral sulfinimine 3 derived from ethyl trifluoropyruvate, followed by acidic hydrolysis of the resulting diastereomeric sulfinamides 4 and 5. Full article
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6 pages, 79 KiB  
Article
An Efficient Synthetic Strategy for the Preparation of Nucleic Acid-Encoded Peptide and Protein Libraries for In Vitro Evolution Protocols
by Markus Kurz, Guannan Kuang and Peter A. Lohse *
Phylos, Inc., 128 Spring Street, Lexington, MA 02421, USA
Molecules 2000, 5(12), 1259-1264; https://doi.org/10.3390/51201259 - 18 Dec 2000
Cited by 4 | Viewed by 7301
Abstract
We describe an improved synthetic strategy for the preparation of nucleic acid encoded peptide and protein libraries. A solid-phase format was used to prepare and purify a novel type of mRNA-template for in vitro mRNA-protein fusion synthesis. The present protocol simplifies and accelerates [...] Read more.
We describe an improved synthetic strategy for the preparation of nucleic acid encoded peptide and protein libraries. A solid-phase format was used to prepare and purify a novel type of mRNA-template for in vitro mRNA-protein fusion synthesis. The present protocol simplifies and accelerates the preparation of fusion libraries and should prove most useful for in vitro protein evolution procedures which involve repetitive cycles of fusion library preparation and selection. Full article
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16 pages, 224 KiB  
Article
Relative Reactivities of Activated Carboxylic Acids in Amide-Forming Reactions Employed for the Synthesis of Tetraphenylporphyrin Libraries
by Kendra L. Dombi and Clemens Richert *
Departments of Chemistry, Tufts University, Medford MA, 02155, USA and University of Constance, Fach 709, D-78457 Konstanz, Germany
Molecules 2000, 5(12), 1265-1280; https://doi.org/10.3390/51201265 - 18 Dec 2000
Cited by 8 | Viewed by 8971
Abstract
Presented here is a method for rapidly testing the reactivity of carboxylic acids in amide-forming reactions. For this, a mixture of two acids, one a reference compound, and one acid whose reactivity is unknown, are coupled to an aminoacylated tetrakis(paminophenyl) porphyrin under typical [...] Read more.
Presented here is a method for rapidly testing the reactivity of carboxylic acids in amide-forming reactions. For this, a mixture of two acids, one a reference compound, and one acid whose reactivity is unknown, are coupled to an aminoacylated tetrakis(paminophenyl) porphyrin under typical peptide coupling conditions. The product distribution in the resulting library is analyzed via MALDI-TOF mass spectrometry to reveal the relative reactivity. This rapid reactivity test requires sub-nanomole quantities of acids, does not involve cleavage from a support or any potentially biasing work-up, and is automatable. Thus, it is well suited for testing building blocks for combinatorial syntheses. Further, it is demonstrated that step-wise coupling can produce near-statistically distributed libraries of porphyrins when acids of very different reactivity are employed. Full article
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6 pages, 46 KiB  
Article
Synthesis of Some Fused Pyrazoles and Isoxazoles
by Venkatapuram Padmavathi *, Boggu Jagan Mohan Reddy, Akula Balaiah, Katta Venugopal Reddy and Dandu Bhaskar Reddy
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India
Molecules 2000, 5(12), 1281-1286; https://doi.org/10.3390/51201281 - 18 Dec 2000
Cited by 54 | Viewed by 8106
Abstract
The α-keto methylene group in 3,5-diaryl-2-cyclohexenones 2 and 3,5-diarylcyclohexanones 8 have been used to obtain fused pyrazoles and isoxazoles. The new compounds were characterized by IR and 1H-NMR spectral data. Full article
4 pages, 25 KiB  
Article
Synthesis of α-Hydroxyacetosyringone
by Fernando Echeverri *, Winston Quiñones, Fernando Torres, Mario Duque and Rosendo Archbold
Department of Chemistry, Universidad de Antioquia, P. O. Box 1226. Medellín, Colombia
Molecules 2000, 5(12), 1287-1290; https://doi.org/10.3390/51201287 - 19 Dec 2000
Cited by 1 | Viewed by 6351
Abstract
A phytoalexin from papaya fruit has been synthesized in four steps; this procedure involved a Pummerer- type reaction. Full article
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40 pages, 343 KiB  
Review
Hydroxyquinones: Synthesis and Reactivity
by Spyros Spyroudis
Laboratory of Organic Chemistry, Chemistry Department, University of Thessaloniki, Thessaloniki 54006, Greece
Molecules 2000, 5(12), 1291-1330; https://doi.org/10.3390/51201291 - 20 Dec 2000
Cited by 98 | Viewed by 24670
Abstract
Quinones having hydroxy groups directly attached to the quinone ring constitute a very interesting class of quinoid compounds. A great number of hydroxyquinones are found in nature and the majority of them exhibit unique biological activity. Their syntheses and their main reactivity patterns [...] Read more.
Quinones having hydroxy groups directly attached to the quinone ring constitute a very interesting class of quinoid compounds. A great number of hydroxyquinones are found in nature and the majority of them exhibit unique biological activity. Their syntheses and their main reactivity patterns are reviewed in this paper. Full article
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41 pages, 286 KiB  
Review
Organic Iodine(I, III, and V) Chemistry: 10 Years of Development at the Medical University of Warsaw, Poland
by Lech Skulski
Chair and Laboratory of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, PL 02-097 Warsaw, Poland
Molecules 2000, 5(12), 1331-1371; https://doi.org/10.3390/51201331 - 20 Dec 2000
Cited by 48 | Viewed by 11680
Abstract
This review reports some novel (or considerably improved) methods for the synthesis of aromatic iodides, (dichloroiodo)arenes, (diacetoxyiodo)arenes, iodylarenes and diaryliodonium salts, as well as some facile, oxidative anion metatheses in crude diaryliodonium halides and, for comparison, potassium halides. All these new results were [...] Read more.
This review reports some novel (or considerably improved) methods for the synthesis of aromatic iodides, (dichloroiodo)arenes, (diacetoxyiodo)arenes, iodylarenes and diaryliodonium salts, as well as some facile, oxidative anion metatheses in crude diaryliodonium halides and, for comparison, potassium halides. All these new results were obtained in our laboratory over the past decade (1990-2000). A full list of our papers dealing with the organic iodine(I, III and V) chemistry, covering exlusively the aromatic derivatives, is also provided. Full article
7 pages, 111 KiB  
Article
Synthesis and Photochemical Cyclization of a Novel Enyne-Carbodiimide
by Michael Schmittel 1,*, David Rodríguez 1,2 and Jens-Peter Steffen 1
1 FB 8 - OC1 (Chemie und Biologie), Universität Siegen, Adolf-Reichwein-Strasse, D-57068 Siegen, Germany
2 Present address: Facultad de Química, Universidad de Santiago de Compostela, Spain
Molecules 2000, 5(12), 1372-1378; https://doi.org/10.3390/51201372 - 20 Dec 2000
Cited by 13 | Viewed by 6543
Abstract
The triplet sensitized cyclization of enyne-carbodiimide 4 leads to efficient formation of indoloquinoline 5 with concomittant loss of a methyl group. The efficient loss of the methyl group was explained using AM1 semiempirical calculations. Full article
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7 pages, 155 KiB  
Article
The Relationship between Redox Potentials and Torsional Angles in 4,4’-Dimethyl N, N’-Alkylidene 2,2’-Bipyridinium Salts
by Yijun Wang and Wenyuan Zhao *
Department of Chemistry, Qingdao University, Qingdao 266071, P.R. China
Molecules 2000, 5(12), 1379-1385; https://doi.org/10.3390/51201379 - 20 Dec 2000
Cited by 4 | Viewed by 6997
Abstract
The redox potentials of 4,4’-dimethyl-N’N’-alkylidene bridged 2,2’-bipyridinium salts derivatives (DBPAs) can be controlled by changing the N, N’-alkylidene bridge length which changes the conformation of the DBPAs.. In this paper, the torsional angles between the two pyridine rings and the molecular energy of [...] Read more.
The redox potentials of 4,4’-dimethyl-N’N’-alkylidene bridged 2,2’-bipyridinium salts derivatives (DBPAs) can be controlled by changing the N, N’-alkylidene bridge length which changes the conformation of the DBPAs.. In this paper, the torsional angles between the two pyridine rings and the molecular energy of DBPAs are calculated using a PC based software package (AccuModel 1.2). The relationship between torsional angle and N, N’-alkylidene bridge length is discussed. The molecular energy of DBPAs can also be related to the torsional angles (or N, N’-alkylidene bridge size). Some DBPAs had been synthesized and their redox potentials measured. The difference in potential between ethylene and propylene bridged DBPAs is large enough to make a organic diode through bilayer modified electrode. Full article
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13 pages, 76 KiB  
Article
Study of Stereoselectivity in Organometallic Additions to 1,2-O-Isopropylidene-O-R-α-D-xylopentodialdo-1,4-furanose
by Tibor Gracza * and Peter Szolcsányi
Department of Organic Chemistry, Faculty of Chemical Technology, Slovak University of Technology, Sk-812 37 Bratislava, Slovakia
Molecules 2000, 5(12), 1386-1398; https://doi.org/10.3390/51201386 - 21 Dec 2000
Cited by 17 | Viewed by 8429
Abstract
Diastereofacial selectivity of the addition of organometallic reagents to 1,2-Oisopropylidene-O-R-α-D-xylopentodialdo-1,4-furanoses (6) was studied. Full article
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9 pages, 132 KiB  
Article
Substitution Effects on Reactivity of N-Acyl-2-amino-2-desoxyglucopyranoses. Quantum Chemical Study
by Aušra Vektariene 1,*, Arvydas Juodviršis 1 and Gytis Vektaris 2
1 Institute of Biochemistry, Mokslininku 12, 2600 Vilnius, Lithuania
2 Institute of Theoretical Physics and Astronomy, A. Goštauto 12, 2600 Vilnius, Lithuania
Molecules 2000, 5(12), 1399-1407; https://doi.org/10.3390/51201399 - 21 Dec 2000
Viewed by 8530
Abstract
Quantum mechanical calculations were carried out to study the molecular geometry and electronic structure of 2-amino-2-desoxyglucopyranose (AG) and the Nacetyl-, N-ethanoyl-, series of N-phthalimidoalkanoyl-AG. The total charge density, electrostatic potential, spatial distribution and positions of HOMO and LUMO of N-acyl-AGs with respect to [...] Read more.
Quantum mechanical calculations were carried out to study the molecular geometry and electronic structure of 2-amino-2-desoxyglucopyranose (AG) and the Nacetyl-, N-ethanoyl-, series of N-phthalimidoalkanoyl-AG. The total charge density, electrostatic potential, spatial distribution and positions of HOMO and LUMO of N-acyl-AGs with respect to their substitutes yield information on the reactivity of the molecules. Full article
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9 pages, 91 KiB  
Article
Halogeno Aldol Reaction of Ethyl Vinyl Ketone and Aldehydes Mediated by Titanium Tetrachloride
by Han-Xun Wei, Subramanian Karur and Guigen Li *
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock TX 79409-1061, USA
Molecules 2000, 5(12), 1408-1416; https://doi.org/10.3390/51201408 - 22 Dec 2000
Cited by 8 | Viewed by 9431
Abstract
A three-component halogeno aldol reaction has been developed by using titanium tetrachloride as the halogen source as well as the Lewis acid mediator. The dehydration and elimination of hydrogen chloride were inhibited by conducting the reaction at 0 °C in dichloromethane or at [...] Read more.
A three-component halogeno aldol reaction has been developed by using titanium tetrachloride as the halogen source as well as the Lewis acid mediator. The dehydration and elimination of hydrogen chloride were inhibited by conducting the reaction at 0 °C in dichloromethane or at room temperature with a shortened reaction time. Seven examples were examined, giving good to high yields (61 - 92%) and modest stereoselectivity (syn/anti: 2.2/1.0 - 8.4/1.0). Full article
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12 pages, 407 KiB  
Article
High-level Computational Study of the Site-, Facial- and Stereoselectivities for the Diels-Alder Reaction Between o-Benzoquinone and Norbornadiene
by Davor Margetic *, Martin R. Johnston and Ronald N. Warrener
Centre for Molecular Architecture, Central Queensland University, Rockhampton, Queensland, 4702, Australia
Molecules 2000, 5(12), 1417-1428; https://doi.org/10.3390/51201417 - 22 Dec 2000
Cited by 14 | Viewed by 10020
Abstract
Ab initio and DFT quantum chemical calculations have been applied to a study of the Diels-Alder reaction of o-benzoquinone as diene and norbornadiene as dienophile. Transition states for the different reactions are located and activation energies estimated. The prefered exo-π-facial selectivity [...] Read more.
Ab initio and DFT quantum chemical calculations have been applied to a study of the Diels-Alder reaction of o-benzoquinone as diene and norbornadiene as dienophile. Transition states for the different reactions are located and activation energies estimated. The prefered exo-Ï€-facial selectivity and exo,endo-stereoselectivity exhibited in this cycloaddition are readily predicted using RHF/3-21G or higher levels of calculations. Differences between experimentally observed results and calculations may be explained by the postulation of a second, nonconcerted biradical mechanism leading to formation of hetero Diels-Alder products. Full article
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10 pages, 117 KiB  
Article
Synthesis and Antimicrobial Activity of Some New Benzimidazole Derivatives
by Afaf H. El-masry *, H. H. Fahmy and S. H. Ali Abdelwahed
Therapeutical Chemistry Department. National Research Centre, Dokki, Cairo, Egypt
Molecules 2000, 5(12), 1429-1438; https://doi.org/10.3390/51201429 - 22 Dec 2000
Cited by 383 | Viewed by 24970
Abstract
Reaction of 3-(2-methylbenzimidazol-1-yl)propanoic acid hydrazide (1) with CS2/KOH gave oxadiazole 2 which underwent Mannich reaction to give 3. Compound 2 was treated with hydrazine hydrate to give triazole 4 which was treated with both aldehydes and acetic anhydride to give 5 [...] Read more.
Reaction of 3-(2-methylbenzimidazol-1-yl)propanoic acid hydrazide (1) with CS2/KOH gave oxadiazole 2 which underwent Mannich reaction to give 3. Compound 2 was treated with hydrazine hydrate to give triazole 4 which was treated with both aldehydes and acetic anhydride to give 5 and 6, respectively. Carbohydrazide 1 was reacted with ethyl acetoacetate, acetylacetone and aldehydes to give 7, 8 and 9, respectively. Cyclocondensation of 9 with thioglycolic and thiolactic acids gave 10 and 11, respectively. Some of these compounds showed potential antimicrobial activities. Full article
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22 pages, 231 KiB  
Review
Cyclohexenonic Long-Chain Fatty Alcohols as Neuronal Growth Stimulators
by Bang Luu 1,*, José-Luis González De Aguilar 1,2 and Céline Girlanda-Junges 1
1 Laboratoire de Chimie Organique des Substances Naturelles, UMR CNRS 7509, Centre de Neurochimie, Université Louis Pasteur, 5, rue Blaise Pascal, 67084 Strasbourg cedex, France
2 Laboratoire de Neurophysiologie Cellulaire et Integrée, UMR CNRS 7519, Université Louis Pasteur, Strasbourg, France
Molecules 2000, 5(12), 1439-1460; https://doi.org/10.3390/51201439 - 22 Dec 2000
Cited by 35 | Viewed by 10544
Abstract
Neurotrophic factors play an important role in the development and maintenance of neurons, thus providing a suitable therapeutic approach for the treatment of neurodegenerative diseases. However, their clinical use has revealed problematic because of a number of technical and biological disadvantages. Among the [...] Read more.
Neurotrophic factors play an important role in the development and maintenance of neurons, thus providing a suitable therapeutic approach for the treatment of neurodegenerative diseases. However, their clinical use has revealed problematic because of a number of technical and biological disadvantages. Among the different strategies proposed to overcome such difficulties, the search for non-peptide substances with neurotrophic potential is giving promising results. Here we will expose major findings in this field, drawing special attention to cyclohexenonic long-chain fatty alcohols, a novel family of compounds that promote neuronal survival and neurite outgrowth. Full article
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54 pages, 375 KiB  
Meeting Report
Meeting Reports and Abstracts: Symposium on Applications of Porphyrins in Medicine and the Fourth School for Young Scientists on the Chemistry of Porphyrins and Related Compounds Ivanovo 2000
by Oleg A. Golubchikov and Tatjana A. Ageeva
Institute of the Solution Chemistry of Russian Academy of Sciences, Akademicheskaya, 1, 153045, Ivanovo, Russian Federation
Molecules 2000, 5(12), 1461-1514; https://doi.org/10.3390/51201461 - 31 Dec 2000
Cited by 3 | Viewed by 5957
Abstract
The Fourth School for Young Scientists on Chemistry of Porphyrins and Related Compounds Ivanovo 2000 and the Symposium "Application of Porphyrins in Medicine" were held at the facilities of Ivanovo State University of Chemistry and Technology and the Institute of the Solution Chemistry [...] Read more.
The Fourth School for Young Scientists on Chemistry of Porphyrins and Related Compounds Ivanovo 2000 and the Symposium "Application of Porphyrins in Medicine" were held at the facilities of Ivanovo State University of Chemistry and Technology and the Institute of the Solution Chemistry of the Russian Academy of Sciences in Ples (Ivanovo region, Russia) from August 21 to August 27, 2000. About a hundred lecturers and young scientists from Russia, Belarus, Ukraine, Italy and Poland took part in the various sessions of the School and Symposium. The main centers (Moscow, Ivanovo, St-Petersburg, etc.) and directions of porphyrin investigation were well represented by Russian lecturers. The School program included lectures on synthesis, physico-chemical, coordination and application properties of porphyrins, phthalocyanines and related macroheterocyclic compounds. [...] Full article
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2 pages, 23 KiB  
New Book Received
Thermodynamics and Kinetics for the Biological Sciences. By Gordon G. Hammes
by Shu-Kun Lin
MDPI, Saengergasse 25, CH-4054 Basel, Switzerland
Molecules 2000, 5(12), 1515-1516; https://doi.org/10.3390/51201515 - 31 Dec 2000
Viewed by 5256
Abstract
Gain a working knowledge of thermodynamics and kinetics with a minimum of mathematics—a guide for individuals in the biological sciences[...] Full article
1 pages, 9 KiB  
New Book Received
Physical Biochemistry: Principles and Applications. By David Sheehan
by Shu-Kun Lin
MDPI, Saengergasse 25, CH-4054 Basel, Switzerland
Molecules 2000, 5(12), 1517; https://doi.org/10.3390/51201517 - 31 Dec 2000
Cited by 1 | Viewed by 8725
Abstract
An accessible and easy-to-read text for students requiring a broad overview of the key techniques used to characterise the structure and function of complex biomacromolecules such as proteins and DNA.[...] Full article
2 pages, 23 KiB  
New Book Received
Combinatorial Chemistry. By Willi Bannwarth and Eduard Felder
by Shu-Kun Lin
MDPI, Saengergasse 25, CH-4054 Basel, Switzerland
Molecules 2000, 5(12), 1518-1519; https://doi.org/10.3390/51201518 - 31 Dec 2000
Viewed by 4281
Abstract
As we enter the new millennium, combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry.[...] Full article
2 pages, 23 KiB  
New Book Received
Carbohydrates in Chemistry and Biology. By Ernst, Beat / Hart, Gerald W. / Sinaÿ, Pierre
by Shu-Kun Lin
MDPI, Saengergasse 25, CH-4054 Basel, Switzerland
Molecules 2000, 5(12), 1520-1521; https://doi.org/10.3390/51201520 - 31 Dec 2000
Viewed by 5091
Abstract
Carbohydrate Chemistry and Glycobiology have witnessed a rapid expansion during the last few years with the development of numerous new, imaginative and efficient syntheses which provide further insight into structures and biological interactions of glycoconjugates.[...] Full article
2 pages, 24 KiB  
New Book Received
Lewis Acids in Organic Synthesis. By Yamamoto, Hisashi
by Shu-Kun Lin
MDPI, Saengergasse 25, CH-4054 Basel, Switzerland
Molecules 2000, 5(12), 1522-1523; https://doi.org/10.3390/51201522 - 31 Dec 2000
Cited by 1 | Viewed by 5219
Abstract
The use of Lewis acids in organic synthesis, especially in catalysis is one of the most rapidly developing fields in synthetic organic chemistry.[...] Full article
2 pages, 25 KiB  
New Book Received
Pharmaceuticals: Classes, Therapeutic Agents, Areas of Application. By McGuire, John L.
by Shu-Kun Lin
MDPI, Saengergasse 25, CH-4054 Basel, Switzerland
Molecules 2000, 5(12), 1524-1525; https://doi.org/10.3390/51201524 - 31 Dec 2000
Cited by 1 | Viewed by 4553
Abstract
The pharmaceutical industry - an important segment of the chemical industry - is technologically prolific.[...] Full article
2 pages, 10 KiB  
New Book Received
Molecular Diversity in Drug Design. Edited by Philip M. Dean
by Shu-Kun Lin
MDPI, Saengergasse 25, CH-4054 Basel, Switzerland
Molecules 2000, 5(12), 1526-1527; https://doi.org/10.3390/51201526 - 31 Dec 2000
Viewed by 4200
Abstract
This book focuses on the theoretical problems associated with molecular diversity as it is being applied in the pharmaceutical industry.[...] Full article
2 pages, 10 KiB  
New Book Received
Advanced Organic Chemistry. Part A: Structure and Mechanisms. Fourth Edition. by Francis A. Carey
by Shu-Kun Lin
MDPI, Saengergasse 25, CH-4054 Basel, Switzerland
Molecules 2000, 5(12), 1528-1529; https://doi.org/10.3390/51201528 - 31 Dec 2000
Cited by 6 | Viewed by 6918
Abstract
Since its original appearance in 1977, Advanced Organic Chemistry has found wide use as a text providing broad coverage of the structure, reactivity and synthesis of organic compounds.[...] Full article
2 pages, 10 KiB  
New Book Received
Synthetic Organic Sonochemistry. Jean-Louis Luche
by Shu-Kun Lin
MDPI, Saengergasse 25, CH-4054 Basel, Switzerland
Molecules 2000, 5(12), 1530-1531; https://doi.org/10.3390/51201530 - 31 Dec 2000
Cited by 1 | Viewed by 4604
Abstract
The use of ultrasound in chemistry – sonochemistry – has grown spectacularly in recent years, resulting in a significant body of empirical research.[...] Full article
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