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Molecules 2000, 5(12), 1224-1239; doi:10.3390/51201224
Article

Chemistry of Substituted Quinolinones. Part VI. Synthesis and Nucleophilic Reactions of 4-Chloro-8-methylquinolin-2(1H)-one and its Thione Analogue

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Received: 12 October 2000; in revised form: 2 November 2000 / Accepted: 9 November 2000 / Published: 18 December 2000
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Abstract: The synthesis of 4-chloro-8-methylquinolin-2(1H)-one and its thione analogue is described. Some nucleophilic substitution reactions of the 4-chloro group were carried out to get new 4-substituted 2-quinolinones and quinolinethiones, such as 4-sulfanyl, hydrazino, azido and amino derivatives, which are of important synthetic use. The structure of the new compounds was established by their elemental analysis, IR and 1H-NMR spectra. Also the mass fragmentation pattern of some products is discussed.
Keywords: quinolinone; quinolinethione; nucleophilic substitution; thiol-thione tautomerism; mass fragmentation quinolinone; quinolinethione; nucleophilic substitution; thiol-thione tautomerism; mass fragmentation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ismail, M.M.; Abass, M.; Hassan, M.M. Chemistry of Substituted Quinolinones. Part VI. Synthesis and Nucleophilic Reactions of 4-Chloro-8-methylquinolin-2(1H)-one and its Thione Analogue. Molecules 2000, 5, 1224-1239.

AMA Style

Ismail MM, Abass M, Hassan MM. Chemistry of Substituted Quinolinones. Part VI. Synthesis and Nucleophilic Reactions of 4-Chloro-8-methylquinolin-2(1H)-one and its Thione Analogue. Molecules. 2000; 5(12):1224-1239.

Chicago/Turabian Style

Ismail, Mostafa M.; Abass, Mohamed; Hassan, Mohamed M. 2000. "Chemistry of Substituted Quinolinones. Part VI. Synthesis and Nucleophilic Reactions of 4-Chloro-8-methylquinolin-2(1H)-one and its Thione Analogue." Molecules 5, no. 12: 1224-1239.


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