Molecules 2000, 5(12), 1224-1239; doi:10.3390/51201224
Article

Chemistry of Substituted Quinolinones. Part VI. Synthesis and Nucleophilic Reactions of 4-Chloro-8-methylquinolin-2(1H)-one and its Thione Analogue

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711 Cairo, Egypt
* Author to whom correspondence should be addressed.
Received: 12 October 2000; in revised form: 2 November 2000 / Accepted: 9 November 2000 / Published: 18 December 2000
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Abstract: The synthesis of 4-chloro-8-methylquinolin-2(1H)-one and its thione analogue is described. Some nucleophilic substitution reactions of the 4-chloro group were carried out to get new 4-substituted 2-quinolinones and quinolinethiones, such as 4-sulfanyl, hydrazino, azido and amino derivatives, which are of important synthetic use. The structure of the new compounds was established by their elemental analysis, IR and 1H-NMR spectra. Also the mass fragmentation pattern of some products is discussed.
Keywords: quinolinone; quinolinethione; nucleophilic substitution; thiol-thione tautomerism; mass fragmentation

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MDPI and ACS Style

Ismail, M.M.; Abass, M.; Hassan, M.M. Chemistry of Substituted Quinolinones. Part VI. Synthesis and Nucleophilic Reactions of 4-Chloro-8-methylquinolin-2(1H)-one and its Thione Analogue. Molecules 2000, 5, 1224-1239.

AMA Style

Ismail MM, Abass M, Hassan MM. Chemistry of Substituted Quinolinones. Part VI. Synthesis and Nucleophilic Reactions of 4-Chloro-8-methylquinolin-2(1H)-one and its Thione Analogue. Molecules. 2000; 5(12):1224-1239.

Chicago/Turabian Style

Ismail, Mostafa M.; Abass, Mohamed; Hassan, Mohamed M. 2000. "Chemistry of Substituted Quinolinones. Part VI. Synthesis and Nucleophilic Reactions of 4-Chloro-8-methylquinolin-2(1H)-one and its Thione Analogue." Molecules 5, no. 12: 1224-1239.

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