Improvement of a Critical Intermediate Step in the Synthesis of a Nitroxide-Based Spin-Labeled Deoxythymidine Analog

doi:10.3390/51201244

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Molecules 2000, 5(12), 1244-1250; doi:10.3390/51201244

Article

Improvement of a Critical Intermediate Step in the Synthesis of a Nitroxide-Based Spin-Labeled Deoxythymidine Analog

Jeannine H. Powell, Edward M. Johnson II and Peter M. Gannett*

Department of Basic Pharmaceutical Sciences, West Virginia University School of Pharmacy, P. O. Box 9530, Morgantown, West Virginia, USA

* Author to whom correspondence should be addressed.

Received: 8 May 2000; in revised form: 13 November 2000 / Accepted: 14 November 2000 / Published: 18 December 2000

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Abstract: Methods to reduce the carboxylic acid moiety in 3-carboxy-2,2,5,5-tetramethylpyrrolin-1-oxyl to an alcohol as an intermediate toward the corresponding aldehyde have been explored and an improved method has been developed.

Keywords: Nitroxide; spin label; reduction; carboxylic acid; alcohol; anhydride

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MDPI and ACS Style

Powell, J.H.; Johnson, E.M., II; Gannett, P.M. Improvement of a Critical Intermediate Step in the Synthesis of a Nitroxide-Based Spin-Labeled Deoxythymidine Analog. Molecules 2000, 5, 1244-1250.

AMA Style

Powell JH, Johnson EM, II, Gannett PM. Improvement of a Critical Intermediate Step in the Synthesis of a Nitroxide-Based Spin-Labeled Deoxythymidine Analog. Molecules. 2000; 5(12):1244-1250.

Chicago/Turabian Style

Powell, Jeannine H.; Johnson, Edward M., II; Gannett, Peter M. 2000. "Improvement of a Critical Intermediate Step in the Synthesis of a Nitroxide-Based Spin-Labeled Deoxythymidine Analog." Molecules 5, no. 12: 1244-1250.

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