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Molecules 2000, 5(12), 1244-1250; doi:10.3390/51201244
Article

Improvement of a Critical Intermediate Step in the Synthesis of a Nitroxide-Based Spin-Labeled Deoxythymidine Analog

, II and *
Department of Basic Pharmaceutical Sciences, West Virginia University School of Pharmacy, P. O. Box 9530, Morgantown, West Virginia, USA
* Author to whom correspondence should be addressed.
Received: 8 May 2000 / Revised: 13 November 2000 / Accepted: 14 November 2000 / Published: 18 December 2000
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Abstract

Methods to reduce the carboxylic acid moiety in 3-carboxy-2,2,5,5-tetramethylpyrrolin-1-oxyl to an alcohol as an intermediate toward the corresponding aldehyde have been explored and an improved method has been developed.
Keywords: Nitroxide; spin label; reduction; carboxylic acid; alcohol; anhydride Nitroxide; spin label; reduction; carboxylic acid; alcohol; anhydride
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Powell, J.H.; Johnson, E.M., II; Gannett, P.M. Improvement of a Critical Intermediate Step in the Synthesis of a Nitroxide-Based Spin-Labeled Deoxythymidine Analog. Molecules 2000, 5, 1244-1250.

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