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Cyclohexenonic Long-Chain Fatty Alcohols as Neuronal Growth Stimulators
Laboratoire de Chimie Organique des Substances Naturelles, UMR CNRS 7509, Centre de Neurochimie, Université Louis Pasteur, 5, rue Blaise Pascal, 67084 Strasbourg cedex, France
Laboratoire de Neurophysiologie Cellulaire et Integrée, UMR CNRS 7519, Université Louis Pasteur, Strasbourg, France
* Author to whom correspondence should be addressed.
Received: 13 November 2000; in revised form: 7 December 2000 / Accepted: 7 December 2000 / Published: 22 December 2000
Abstract: Neurotrophic factors play an important role in the development and maintenance of neurons, thus providing a suitable therapeutic approach for the treatment of neurodegenerative diseases. However, their clinical use has revealed problematic because of a number of technical and biological disadvantages. Among the different strategies proposed to overcome such difficulties, the search for non-peptide substances with neurotrophic potential is giving promising results. Here we will expose major findings in this field, drawing special attention to cyclohexenonic long-chain fatty alcohols, a novel family of compounds that promote neuronal survival and neurite outgrowth.
Keywords: cyclohexenonic long-chain fatty alcohol; neurite outgrowth; neuronal survival; neurotrophic compound; neurotrophic factor; NGF; synthesis
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Luu, B.; De Aguilar, J.-L.G.; Girlanda-Junges, C. Cyclohexenonic Long-Chain Fatty Alcohols as Neuronal Growth Stimulators. Molecules 2000, 5, 1439-1460.
Luu B, De Aguilar J-LG, Girlanda-Junges C. Cyclohexenonic Long-Chain Fatty Alcohols as Neuronal Growth Stimulators. Molecules. 2000; 5(12):1439-1460.
Luu, Bang; De Aguilar, José-Luis G.; Girlanda-Junges, Céline. 2000. "Cyclohexenonic Long-Chain Fatty Alcohols as Neuronal Growth Stimulators." Molecules 5, no. 12: 1439-1460.