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Molecules 2000, 5(12), 1439-1460; doi:10.3390/51201439

Cyclohexenonic Long-Chain Fatty Alcohols as Neuronal Growth Stimulators

1
Laboratoire de Chimie Organique des Substances Naturelles, UMR CNRS 7509, Centre de Neurochimie, Université Louis Pasteur, 5, rue Blaise Pascal, 67084 Strasbourg cedex, France
2
Laboratoire de Neurophysiologie Cellulaire et Integrée, UMR CNRS 7519, Université Louis Pasteur, Strasbourg, France
*
Author to whom correspondence should be addressed.
Received: 13 November 2000 / Revised: 7 December 2000 / Accepted: 7 December 2000 / Published: 22 December 2000
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Abstract

Neurotrophic factors play an important role in the development and maintenance of neurons, thus providing a suitable therapeutic approach for the treatment of neurodegenerative diseases. However, their clinical use has revealed problematic because of a number of technical and biological disadvantages. Among the different strategies proposed to overcome such difficulties, the search for non-peptide substances with neurotrophic potential is giving promising results. Here we will expose major findings in this field, drawing special attention to cyclohexenonic long-chain fatty alcohols, a novel family of compounds that promote neuronal survival and neurite outgrowth.
Keywords: cyclohexenonic long-chain fatty alcohol; neurite outgrowth; neuronal survival; neurotrophic compound; neurotrophic factor; NGF; synthesis cyclohexenonic long-chain fatty alcohol; neurite outgrowth; neuronal survival; neurotrophic compound; neurotrophic factor; NGF; synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Luu, B.; De Aguilar, J.-L.G.; Girlanda-Junges, C. Cyclohexenonic Long-Chain Fatty Alcohols as Neuronal Growth Stimulators. Molecules 2000, 5, 1439-1460.

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