Special Issue "Respiratory and Nasal Drug Delivery"


A special issue of Pharmaceutics (ISSN 1999-4923).

Deadline for manuscript submissions: closed (20 December 2013)

Special Issue Editor

Guest Editor
Dr. Remigius U. Agu
Biopharmaceutics and Drug Delivery Laboratory, Dalhousie University, Halifax NS, Canada
Website: http://www.agulab.com
E-Mail: remigius.agu@dal.ca
Interests: respiratory/nasal; transporters; toxicity screening; drug delivery

Special Issue Information

Dear Colleagues,

Novel developments in the fields of Biotechnology and Combinatorial Chemistry rekindled overall interest in exploring the respiratory and nasal routes for systemic delivery of biomolecules (e.g., proteins, peptides and nucleic acids). Pursuits in these areas of drug delivery are not limited to macromolecules and systemic delivery. Many research groups are consistently looking for more effective ways to deliver small molecules local to the lung, nasal sinuses and brain via the nasal route. Novel approaches for efficient systemic and local drug delivery have been developed over the past few years. Such strategies include novel formulations (micro/nano particles, stent) and delivery devices. Successful respiratory and nasal drug delivery also requires sound experimental methods/model development. This special issue entitled: "Respiratory and Nasal Drug Delivery" will deal with key aspects of modern respiratory and nasal delivery. Micro-/nano-particulate delivery; formulation/delivery of aerosols and dry powders; optimization of nasal and respiratory drug absorption using in vitro, ex vivo and in situ tissue culture and animal models; brain targeting via the nasal route; exploration of mechanisms of epithelial drug permeation (e.g., active transport mechanisms); aerosol delivery simulation and other particle projectile studies; toxicological aspects of nasal and respiratory drug delivery, especially micro and nanoparticles; pharmacodynamics and pharmacokinetics of novel formulations following nasal and inhalational administration will be covered. Other relevant topics including muco-/bio-adhesive delivery, cilio-toxicity screening, delivery devices development, optimization and validation are also welcomed.

Dr. Remigius U. Agu
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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  • respiratory
  • nasal
  • pulmonary
  • drug delivery
  • devices
  • aerosol
  • drug targeting

Published Papers (4 papers)

Pharmaceutics 2014, 6(2), 195-219; doi:10.3390/pharmaceutics6020195
Received: 20 December 2013; in revised form: 24 March 2014 / Accepted: 31 March 2014 / Published: 11 April 2014
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Pharmaceutics 2014, 6(1), 175-184; doi:10.3390/pharmaceutics6010175
Received: 5 November 2013; in revised form: 22 January 2014 / Accepted: 13 February 2014 / Published: 21 March 2014
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Pharmaceutics 2014, 6(1), 36-51; doi:10.3390/pharmaceutics6010036
Received: 20 December 2013; in revised form: 20 January 2014 / Accepted: 23 January 2014 / Published: 6 February 2014
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Pharmaceutics 2014, 6(1), 26-35; doi:10.3390/pharmaceutics6010026
Received: 13 September 2013; in revised form: 23 January 2014 / Accepted: 26 January 2014 / Published: 29 January 2014
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Review
Title: The Current Progress in the Development of DNA Vaccine for Intranasal Administration
Author: Jenny Lam
Abstract: Intranasal delivery of DNA vaccines has become a popular research area recently. It offers some distinguished advantages over oral or parenteral route of vaccine administration, Nasal mucosal as site of vaccine administration can stimulate respiratory mucosal immunity by interacting with the nasal-associated lymphoid tissues. Different kinds of DNA vaccines are investigated to provide protection against influenza, tuberculosis, respiratory syncytial virus (RSV) and cancer /etc./. DNA vaccines have some attractive development potential, like producing cross-protection towards different influenza subtypes, enabling the possibility of mass manufacture in a relatively short time, and reducing excessive adverse immune responses which, may pose safety problems. In this review, the latest research of DNA vaccine that is designed for intranasal administration are discussed in details.

Title: Analytical challenges and regulatory requirements for nasal drug products in Europe and the US
Author: Prof. Dr. Hartwig Steckel
Abstract: The intranasal route offers great opportunities for both local and systemic administration of drugs and represents an attractive alternative to the oral or intravenous route. Nasal drug delivery can be assessed by a variety of means and regulatory agencies, e.g., FDA and EMA, have published a set of guidelines and regulations proposing in vitro test methods for the characterization of nasal drug products. However, methodologies and details on how to conduct the studies are often missing.This article gives an overview of tests methods required by the FDA and EMA regarding the characterization of nasal drug products and will highlight analogies and differences between the guidelines. Additionally, analytical challenges in the characterization of solution nasal sprays will be reviewed and supported by results from our own studies. These comprise i.a. the determination of droplet size distribution and shot weights and focus on the identification of possible method-, device- and formulation-dependant influencing factors.

Title: Potential Application of Inhalation Drug Delivery to Lung Cancer Treatment
Sunday Shoyele
Department of Pharmaceutical Sciences, School of Pharmarcy, Thomas Jefferson University, Philadelphia, PA
Abstract: Lung cancer is the leading cause of cancer deaths worldwide with a 5-year survival rate of less than 15% for all stages combined. Despite some recent advances in drug discovery, toxicity still remains an issue in the treatment of this highly debilitating disease. Toxicity of most anticancer agents is often attributed to unexpected uptake of such agents by normal tissues and organs. Although, lung cancer is most often a metastatic disease, local delivery of therapeutic agents to the lung by inhalation could potentially act as an additional weapon in the growing arsenal of strategies against lung cancer. In this timely review, we take a critical look at how inhalation as a delivery strategy could be applied to lung cancer treatment. A comprehensive analysis of different factors such as particle design, devices, challenges and early breakthrough is undertaken.
Keywords: lung cancer; inhalation, particle design, drug delivery, toxicity; drug targeting

Last update: 24 October 2013

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