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Pharmaceutics 2014, 6(2), 249-267; doi:10.3390/pharmaceutics6020249

Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges

1
Biopharmaceutics and Drug Delivery Lab, College of Pharmacy, 5968 College Street, P.O. Box 15000, Halifax, NS B3H 4R2, Canada
2
Queen Elizabeth II (QEII) Health Sciences Centre, 1278 Tower Road, Halifax, NS B3H 2Y9, Canada
*
Author to whom correspondence should be addressed.
Received: 26 January 2014 / Revised: 28 March 2014 / Accepted: 7 May 2014 / Published: 27 May 2014
(This article belongs to the Special Issue Respiratory and Nasal Drug Delivery)
View Full-Text   |   Download PDF [582 KB, uploaded 27 May 2014]   |  

Abstract

Chronic inflammation and infection of the nasal sinuses, also referred to as Chronic Rhinosinusitis (CRS), severely affects patients’ quality of life. Adhesions, ostial stenosis, infection and inflammation relapses complicate chronic sinusitis treatment strategies. Drug-eluting stents, packings or implants have been suggested as reasonable alternatives for addressing these concerns. This article reviewed potential drug candidates for nasal implants, formulation methods/optimization and characterization methods. Clinical applications and important considerations were also addressed. Clinically-approved implants (Propel™ implant, the Relieva stratus™ MicroFlow spacer, and the Sinu-Foam™ spacer) for CRS treatment was an important focus. The advantages and limitations, as well as future considerations, challenges and the need for additional research in the field of nasal drug implant development, were discussed. View Full-Text
Keywords: nasal; sinuses; rhinosinusitis; stents; implants; inserts; sustained-release nasal; sinuses; rhinosinusitis; stents; implants; inserts; sustained-release
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Parikh, A.; Anand, U.; Ugwu, M.C.; Feridooni, T.; Massoud, E.; Agu, R.U. Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges. Pharmaceutics 2014, 6, 249-267.

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