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Polysaccharide-Based Micelles for Drug Delivery
Syracuse Biomaterial Institute, 318 Bowne Hall, Syracuse University, Syracuse, NY 13244, USA
* Author to whom correspondence should be addressed.
Received: 22 January 2013; in revised form: 9 May 2013 / Accepted: 16 May 2013 / Published: 27 May 2013
Abstract: Delivery of hydrophobic molecules and proteins has been an issue due to poor bioavailability following administration. Thus, micelle carrier systems are being investigated to improve drug solubility and stability. Due to problems with toxicity and immunogenicity, natural polysaccharides are being explored as substitutes for synthetic polymers in the development of new micelle systems. By grafting hydrophobic moieties to the polysaccharide backbone, self-assembled micelles can be readily formed in aqueous solution. Many polysaccharides also possess inherent bioactivity that can facilitate mucoadhesion, enhanced targeting of specific tissues, and a reduction in the inflammatory response. Furthermore, the hydrophilic nature of some polysaccharides can be exploited to enhance circulatory stability. This review will highlight the advantages of polysaccharide use in the development of drug delivery systems and will provide an overview of the polysaccharide-based micelles that have been developed to date.
Keywords: polysaccharides; micelles; drug delivery; self-assembly; nanocarrier
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MDPI and ACS Style
Zhang, N.; Wardwell, P.R.; Bader, R.A. Polysaccharide-Based Micelles for Drug Delivery. Pharmaceutics 2013, 5, 329-352.
Zhang N, Wardwell PR, Bader RA. Polysaccharide-Based Micelles for Drug Delivery. Pharmaceutics. 2013; 5(2):329-352.
Zhang, Nan; Wardwell, Patricia R.; Bader, Rebecca A. 2013. "Polysaccharide-Based Micelles for Drug Delivery." Pharmaceutics 5, no. 2: 329-352.