Next Article in Journal
Glutathione Transferase (GST)-Activated Prodrugs
Next Article in Special Issue
Polysaccharide-Based Micelles for Drug Delivery
Previous Article in Journal
Drug Adverse Event Detection in Health Plan Data Using the Gamma Poisson Shrinker and Comparison to the Tree-based Scan Statistic
Previous Article in Special Issue
Pharmacokinetic Evaluation of a DSPE-PEG2000 Micellar Formulation of Ridaforolimus in Rat
Pharmaceutics 2013, 5(1), 201-219; doi:10.3390/pharmaceutics5010201
Review

Exploring Polymeric Micelles for Improved Delivery of Anticancer Agents: Recent Developments in Preclinical Studies

* ,
 and
Cancer Nanomedicine Laboratory, Department of Pharmaceutical Sciences, Mercer University, Atlanta, GA 30341, USA
* Author to whom correspondence should be addressed.
Received: 21 December 2012 / Revised: 28 February 2013 / Accepted: 13 March 2013 / Published: 22 March 2013
(This article belongs to the Special Issue Micellar Drug Delivery)
View Full-Text   |   Download PDF [269 KB, uploaded 22 March 2013]   |   Browse Figure

Abstract

As versatile drug delivery systems, polymeric micelles have demonstrated particular strength in solubilizing hydrophobic anticancer drugs while eliminating the use of toxic organic solvents and surfactants. However, the true promise of polymeric micelles as drug carriers for cancer therapy resides in their potential ability to preferentially elevate drug exposure in the tumor and achieve enhanced anticancer efficacy, which still remains to be fully exploited. Here, we review various micellar constructs that exhibit the enhanced permeation and retention effect in the tumor, the targeting ligands that potentiate the anticancer efficacy of micellar drugs, and the polyplex micelle systems suitable for the delivery of plasmid DNA and small interference RNA. Together, these preclinical studies in animal models help us further explore polymeric micelles as emerging drug carriers for targeted cancer therapy.
Keywords: block polymer; EPR effect; tumor-targeting ligand; pharmacokinetics; targeted cancer therapy block polymer; EPR effect; tumor-targeting ligand; pharmacokinetics; targeted cancer therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Tan, C.; Wang, Y.; Fan, W. Exploring Polymeric Micelles for Improved Delivery of Anticancer Agents: Recent Developments in Preclinical Studies. Pharmaceutics 2013, 5, 201-219.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert