Special Issue "Antibacterial Activity of Nanomaterials"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 28 February 2018

Special Issue Editor

Guest Editor
Prof. Dr. Ana María Díez-Pascual

Analytical Chemistry, Physical Chemistry and Chemical Engineering Department, Faculty of Biology, Environmental Sciences and Chemistry, Alcalá University, Alcalá de Henares, Spain
Website | E-Mail
Interests: nanomaterials; polymers; nanocomposites; inorganic nanoparticles; antibacterial agents; surfactants; interphases

Special Issue Information

Dear Colleagues,

Bacterial adhesion and proliferation is a serious and increasing concern in everyday life, and is responsible for significant damage in several industries, including textile, water treatment, marine transport, medicine and food packaging. Notwithstanding the enormous efforts by academic researchers and industry, a general solution for restricting bacterial colonization has not been found yet. Therefore, new strategies for controlling bacteria activity are urgently needed and nanomaterials constitute a very promising approach. This Special Issue plans to give an overview of the most recent advances in the field of antibacterial nanomaterials and their applications in diverse areas. The Special Issue is aimed at providing selected contributions on advances in the synthesis, characterization, and applications of nanomaterials with antibacterial activity.

Potential topics include, but are not limited to:
• Antimicrobial nanoparticles
• Antibacterial nanocoatings and nanocomposites
• Mechanisms of action
• Antimicrobial food packaging
• Adverse effects of nanomaterials
• Future perspectives for antimicrobial nanomaterials
• Role of antimicrobial nanomaterials in medicine

Prof. Dr. Ana María Díez-Pascual
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Antibacterial activity
  • Nanocomposites
  • Bacterial infection
  • Nanotoxicology
  • Antibiotic resistance

Published Papers (9 papers)

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Open AccessArticle Cationic Biomimetic Particles of Polystyrene/Cationic Bilayer/Gramicidin for Optimal Bactericidal Activity
Nanomaterials 2017, 7(12), 422; doi:10.3390/nano7120422
Received: 30 October 2017 / Revised: 23 November 2017 / Accepted: 29 November 2017 / Published: 2 December 2017
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Abstract
Nanostructured particles of polystyrene sulfate (PSS) covered by a cationic lipid bilayer of dioctadecyldimethylammonium bromide (DODAB) incorporated gramicidin D (Gr) yielding optimal and broadened bactericidal activity against both Escherichia coli and Staphylococcus aureus. The adsorption of DODAB/Gr bilayer onto PSS nanoparticles (NPs)
[...] Read more.
Nanostructured particles of polystyrene sulfate (PSS) covered by a cationic lipid bilayer of dioctadecyldimethylammonium bromide (DODAB) incorporated gramicidin D (Gr) yielding optimal and broadened bactericidal activity against both Escherichia coli and Staphylococcus aureus. The adsorption of DODAB/Gr bilayer onto PSS nanoparticles (NPs) increased the zeta-average diameter by 8–10 nm, changed the zeta-potential of the NPs from negative to positive, and yielded a narrow size distributions for the PSS/DODAB/Gr NPs, which displayed broad and maximal microbicidal activity at very small concentrations of the antimicrobials, namely, 0.057 and 0.0057 mM DODAB and Gr, respectively. The results emphasized the advantages of highly-organized, nanostructured, and cationic particles to achieve hybrid combinations of antimicrobials with broad spectrum activity at considerably reduced DODAB and Gr concentrations. Full article
(This article belongs to the Special Issue Antibacterial Activity of Nanomaterials)
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Open AccessArticle Inhibition of Bacteria Associated with Wound Infection by Biocompatible Green Synthesized Gold Nanoparticles from South African Plant Extracts
Nanomaterials 2017, 7(12), 417; doi:10.3390/nano7120417
Received: 11 October 2017 / Revised: 9 November 2017 / Accepted: 10 November 2017 / Published: 26 November 2017
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Abstract
Unlike conventional physical and chemical methods, the biogenic synthesis of gold nanoparticles (GNPs) is considered a green and non-toxic approach to produce biocompatible GNPs that can be utilized in various biomedical applications. This can be achieved by using plant-derived phytochemicals to reduce gold
[...] Read more.
Unlike conventional physical and chemical methods, the biogenic synthesis of gold nanoparticles (GNPs) is considered a green and non-toxic approach to produce biocompatible GNPs that can be utilized in various biomedical applications. This can be achieved by using plant-derived phytochemicals to reduce gold salt into GNPs. Several green synthesized GNPs have been shown to have antibacterial effects, which can be applied in wound dressings to prevent wound infections. Therefore, the aim of this study is to synthesize biogenic GNPs from the South African Galenia africana and Hypoxis hemerocallidea plants extracts and evaluate their antibacterial activity, using the Alamar blue assay, against bacterial strains that are known to cause wound infections. Additionally, we investigated the toxicity of the biogenic GNPs to non-cancerous human fibroblast cells (KMST-6) using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay. In this paper, spherical GNPs, with particle sizes ranging from 9 to 27 nm, were synthesized and fully characterized. The GNPs from H. hemerocallidea exhibited antibacterial activity against all the tested bacterial strains, whereas GNPs produced from G. africana only exhibited antibacterial activity against Pseudomonas aeruginosa. The GNPs did not show any significant toxicity towards KMST-6 cells, which may suggest that these nanoparticles can be safely applied in wound dressings. Full article
(This article belongs to the Special Issue Antibacterial Activity of Nanomaterials)
Open AccessArticle Synergistic Effect of Fluorinated and N Doped TiO2 Nanoparticles Leading to Different Microstructure and Enhanced Photocatalytic Bacterial Inactivation
Nanomaterials 2017, 7(11), 391; doi:10.3390/nano7110391
Received: 9 October 2017 / Revised: 9 November 2017 / Accepted: 10 November 2017 / Published: 15 November 2017
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Abstract
This work focuses on the development of a facile and scalable wet milling method followed by heat treatment to prepare fluorinated and/or N-doped TiO2 nanopowders with improved photocatalytic properties under visible light. The structural and electronic properties of doped particles were investigated
[...] Read more.
This work focuses on the development of a facile and scalable wet milling method followed by heat treatment to prepare fluorinated and/or N-doped TiO2 nanopowders with improved photocatalytic properties under visible light. The structural and electronic properties of doped particles were investigated by various techniques. The successful doping of TiO2 was confirmed by X-ray photoelectron spectroscopy (XPS), and the atoms appeared to be mainly located in interstitial positions for N whereas the fluorination is located at the TiO2 surface. The formation of intragap states was found to be responsible for the band gap narrowing leading to the faster bacterial inactivation dynamics observed for the fluorinated and N doped TiO2 particles compared to N-doped TiO2. This was attributed to a synergistic effect. The results presented in this study confirmed the suitability of the preparation approach for the large-scale production of cost-efficient doped TiO2 for effective bacterial inactivation. Full article
(This article belongs to the Special Issue Antibacterial Activity of Nanomaterials)
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Open AccessArticle One-Pot Facile Methodology to Synthesize Chitosan-ZnO-Graphene Oxide Hybrid Composites for Better Dye Adsorption and Antibacterial Activity
Nanomaterials 2017, 7(11), 363; doi:10.3390/nano7110363
Received: 16 September 2017 / Revised: 27 October 2017 / Accepted: 30 October 2017 / Published: 2 November 2017
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Abstract
Novel chitosan–ZnO–graphene oxide hybrid composites were prepared using a one-pot chemical strategy, and their dye adsorption characteristics and antibacterial activity were demonstrated. The prepared chitosan and the hybrids such as chitosan–ZnO and chitosan–ZnO–graphene oxide were characterized by UV-Vis absorption spectroscopy, X-ray diffraction, Fourier
[...] Read more.
Novel chitosan–ZnO–graphene oxide hybrid composites were prepared using a one-pot chemical strategy, and their dye adsorption characteristics and antibacterial activity were demonstrated. The prepared chitosan and the hybrids such as chitosan–ZnO and chitosan–ZnO–graphene oxide were characterized by UV-Vis absorption spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy. The thermal and mechanical properties indicate a significant improvement over chitosan in the hybrid composites. Dye adsorption experiments were carried out using methylene blue and chromium complex as model pollutants with the function of dye concentration. The antibacterial properties of chitosan and the hybrids were tested against Gram-positive and Gram-negative bacterial species, which revealed minimum inhibitory concentrations (MICs) of 0.1 µg/mL. Full article
(This article belongs to the Special Issue Antibacterial Activity of Nanomaterials)
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Open AccessArticle Poly-L-arginine Coated Silver Nanoprisms and Their Anti-Bacterial Properties
Nanomaterials 2017, 7(10), 296; doi:10.3390/nano7100296
Received: 26 July 2017 / Revised: 13 September 2017 / Accepted: 22 September 2017 / Published: 27 September 2017
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Abstract
The aim of this study was to test the effect of two different morphologies of silver nanoparticles, spheres, and prisms, on their antibacterial properties when coated with poly-L-arginine (poly-Arg) to enhance the interactions with cells. Silver nanoparticle solutions were characterized by
[...] Read more.
The aim of this study was to test the effect of two different morphologies of silver nanoparticles, spheres, and prisms, on their antibacterial properties when coated with poly-L-arginine (poly-Arg) to enhance the interactions with cells. Silver nanoparticle solutions were characterized by UV–visible spectroscopy, transmission electron microscopy, dynamic light scattering, zeta potential, as well as antimicrobial tests. These ultimately showed that a prismatic morphology exhibited stronger antimicrobial effects against Escherichia coli, Pseudomonas aeruginosa and Salmonella enterica. The minimum bactericidal concentration was found to be 0.65 μg/mL in the case of a prismatic AgNP-poly-Arg-PVP (silver nanoparticle-poly-L-arginine-polyvinylpyrrolidone) nanocomposite. The anticancer cell activity of the silver nanoparticles was also studied, where the maximum effect against a HeLa cell line was 80% mortality with a prismatic AgNP-poly-Arg-PVP nanocomposite at a concentration of 11 μg/mL. The antimicrobial activity of these silver nanocomposites demonstrates the potential of such coated silver nanoparticles in the area of nano-medicine. Full article
(This article belongs to the Special Issue Antibacterial Activity of Nanomaterials)
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Open AccessArticle Nanosilver–Silica Composite: Prolonged Antibacterial Effects and Bacterial Interaction Mechanisms for Wound Dressings
Nanomaterials 2017, 7(9), 261; doi:10.3390/nano7090261
Received: 24 July 2017 / Revised: 22 August 2017 / Accepted: 3 September 2017 / Published: 6 September 2017
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Abstract
Infected superficial wounds were traditionally controlled by topical antibiotics until the emergence of antibiotic-resistant bacteria. Silver (Ag) is a kernel for alternative antibacterial agents to fight this resistance quandary. The present study demonstrates a method for immobilizing small-sized (~5 nm) silver nanoparticles on
[...] Read more.
Infected superficial wounds were traditionally controlled by topical antibiotics until the emergence of antibiotic-resistant bacteria. Silver (Ag) is a kernel for alternative antibacterial agents to fight this resistance quandary. The present study demonstrates a method for immobilizing small-sized (~5 nm) silver nanoparticles on silica matrix to form a nanosilver–silica (Ag–SiO2) composite and shows the prolonged antibacterial effects of the composite in vitro. The composite exhibited a rapid initial Ag release after 24 h and a slower leaching after 48 and 72 h and was effective against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli). Ultraviolet (UV)-irradiation was superior to filter-sterilization in retaining the antibacterial effects of the composite, through the higher remaining Ag concentration. A gauze, impregnated with the Ag–SiO2 composite, showed higher antibacterial effects against MRSA and E. coli than a commercial Ag-containing dressing, indicating a potential for the management and infection control of superficial wounds. Transmission and scanning transmission electron microscope analyses of the composite-treated MRSA revealed an interaction of the released silver ions with the bacterial cytoplasmic constituents, causing ultimately the loss of bacterial membranes. The present results indicate that the Ag–SiO2 composite, with prolonged antibacterial effects, is a promising candidate for wound dressing applications. Full article
(This article belongs to the Special Issue Antibacterial Activity of Nanomaterials)
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Open AccessArticle Antimicrobial Properties of Silver Cations Substituted to Faujasite Mineral
Nanomaterials 2017, 7(9), 240; doi:10.3390/nano7090240
Received: 10 July 2017 / Revised: 7 August 2017 / Accepted: 25 August 2017 / Published: 27 August 2017
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Abstract
A goal of our study was to find an alternative to nano-silver-based antimicrobial materials which would contain active silver immobilized in a solid matrix that prevents its migration into the surrounding environment. In this study, we investigated whether silver cations dispersed in an
[...] Read more.
A goal of our study was to find an alternative to nano-silver-based antimicrobial materials which would contain active silver immobilized in a solid matrix that prevents its migration into the surrounding environment. In this study, we investigated whether silver cations dispersed in an atomic form and trapped in an ion-exchanged zeolite show comparable antimicrobial activity to silver nanoparticles (NPs). The biocidal active material was prepared from the sodium form of faujasite type zeolite in two steps: (1) exchange with silver cations, (2) removal of the external silver oxide NPs by elution with Na2EDTA solution. The modified biocidal zeolite was then added to paper pulp to obtain sheets. The zeolite paper samples and reference samples containing silver NPs were tested in terms of biocidal activity against an array of fungi and bacteria strains, including Escherichia coli, Serratia marcescens, Bacillus subtilis, Bacillus megaterium, Trichoderma viride, Chaetomium globosum, Aspergillus niger, Cladosporium cladosporioides, and Mortierella alpina. The paper with the modified faujasite additive showed higher or similar antibacterial and antifungal activities towards the majority of tested microbes in comparison with the silver NP-filled paper. A reverse effect was observed for the Mortierella alpina strain. Full article
(This article belongs to the Special Issue Antibacterial Activity of Nanomaterials)
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Open AccessArticle Eco-Friendly Acaricidal Effects of Nylon 66 Nanofibers via Grafted Clove Bud Oil-Loaded Capsules on House Dust Mites
Nanomaterials 2017, 7(7), 179; doi:10.3390/nano7070179
Received: 23 June 2017 / Revised: 4 July 2017 / Accepted: 6 July 2017 / Published: 10 July 2017
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Abstract
Acaricidal nylon 66 fabrics (AN66Fs) grafted with clove oil-loaded microcapsules (COMCs) were developed against Dermatophagoides farina (D. gallinae). The average diameter was about 2.9 µm with a range of 100 nm–8.5 µm. COMCs carried clove oil loading of about 65 vol
[...] Read more.
Acaricidal nylon 66 fabrics (AN66Fs) grafted with clove oil-loaded microcapsules (COMCs) were developed against Dermatophagoides farina (D. gallinae). The average diameter was about 2.9 µm with a range of 100 nm–8.5 µm. COMCs carried clove oil loading of about 65 vol %. COMCs were chemically grafted to electrospun nylon nanofibers by the chemical reactions between –OH groups of COMCs and –COOH end groups of nylon fabrics to form ester linkages. AN66Fs had an effect on D. farinae depending on COMCs loadings. The increase in COMCs loading of AN66Fs from 5 to 15 wt % increased from 22% to 93% mortality against D. farinae within 72 h. However, AN66Fs containing over 20 wt % COMCs were more effective, showing up to 100% mortality within 24 h because the large amount of monoterpene alcohol, eugenol. This research suggests the use of clove oil and its major constituent eugenol as eco-friendly bioactive agents that can serve as a replacement for synthetic acaricides in controlling the population of D. farinae. Full article
(This article belongs to the Special Issue Antibacterial Activity of Nanomaterials)
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Open AccessCommentary Antimicrobial Nanomaterials: Why Evolution Matters
Nanomaterials 2017, 7(10), 283; doi:10.3390/nano7100283
Received: 29 August 2017 / Revised: 14 September 2017 / Accepted: 18 September 2017 / Published: 21 September 2017
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Abstract
Due to the widespread occurrence of multidrug resistant microbes there is increasing interest in the use of novel nanostructured materials as antimicrobials. Specifically, metallic nanoparticles such as silver, copper, and gold have been deployed due to the multiple impacts they have on bacterial
[...] Read more.
Due to the widespread occurrence of multidrug resistant microbes there is increasing interest in the use of novel nanostructured materials as antimicrobials. Specifically, metallic nanoparticles such as silver, copper, and gold have been deployed due to the multiple impacts they have on bacterial physiology. From this, many have concluded that such nanomaterials represent steep obstacles against the evolution of resistance. However, we have already shown that this view is fallacious. For this reason, the significance of our initial experiments are beginning to be recognized in the antimicrobial effects of nanomaterials literature. This recognition is not yet fully understood and here we further explain why nanomaterials research requires a more nuanced understanding of core microbial evolution principles. Full article
(This article belongs to the Special Issue Antibacterial Activity of Nanomaterials)

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Preparation of graphene oxide – silver nanocomposite: Effect of silver concentrations on antibacterial activity
Author: Shing-jiang Jessie Lue

 

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