Special Issue "Frontiers in Toxicity and Functionalization of Nanomaterials"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 30 September 2017

Special Issue Editors

Guest Editor
Prof. Dr. Dong-Wook Han

College of Nanoscience & Nanotechnology, Pusan National University (PNU), Busandaehak-ro 63beon-gil 2, Geumjeong-gu, Busan 46241, Korea
Website | E-Mail
Interests: carbon-based nanomaterials; nanotoxicity; nanobioelectronics; nanomedicine; biocompatibility evaluation
Guest Editor
Dr. Wojciech Chrzanowski

Australian Institute of Nanoscale Science and Technology (Health and Medicine Theme Leader), Faculty of Pharmacy, The University of Sydney, Pharmacy and Bank Building A15, Camperdown, NSW 2006, Australia
Website | E-Mail
Interests: nanomedicine; biointefaces; nanomaterials; nanocharacterisation

Special Issue Information

Dear Colleagues,

Over the last decade, various nanomaterials (NMs) have attracted tremendous attention with the incredible development in nanoscience and nanotechnology. Some NMs are explored increasingly for biomedical applications including drug delivery carriers, imaging probes, antimicrobial agents, biosensors and tissue engineering scaffolds. However, the in vitro and in vivo toxicities of NMs related to oxidative stress are the main obstacles to use them in biomedical fields. One of the most promising strategies to address these obstacles is functionalizing NMs with biocompatible molecules or materials.

In this Special Issue, we are especially interested in manuscripts that advance the understanding of the interaction of NMs with cells, tissues, organs and systems as well as the relationship between intrinsic property and biocompatibility of NMs. This Special Issue invites manuscripts ranging from understanding all toxicological aspects, such as cytotoxicity, genotoxicity, hemotoxicity, neurotoxicity, immunotoxicity, histotoxicity and systemic toxicity of NMs. Manuscripts that focus on specific approaches and strategies to modify NMs with biofunctional moieties are also invited.

Prof. Dr. Dong-Wook Han
Dr. Wojciech Chrzanowski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical applications,
  • nanotoxicity,
  • cell-nanomaterial interactions,
  • biocompatibility,
  • nanomaterial functionalization

Published Papers (4 papers)

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Research

Open AccessArticle Antioxidant Potential and Antibacterial Efficiency of Caffeic Acid-Functionalized ZnO Nanoparticles
by , , , , , and
Nanomaterials 2017, 7(6), 148; doi:10.3390/nano7060148
Received: 2 May 2017 / Revised: 13 June 2017 / Accepted: 14 June 2017 / Published: 16 June 2017
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Abstract
We report a novel zinc oxide (ZnO) nanoparticle with antioxidant properties, prepared by immobilizing the antioxidant 3-(3,4-dihydroxyphenyl)-2-propenoic acid (caffeic acid, CA) on the surfaces of micro-dielectric barrier discharge (DBD) plasma-treated ZnO nanoparticles. The microstructure and physical properties of ZnO@CA nanoparticles were characterized by
[...] Read more.
We report a novel zinc oxide (ZnO) nanoparticle with antioxidant properties, prepared by immobilizing the antioxidant 3-(3,4-dihydroxyphenyl)-2-propenoic acid (caffeic acid, CA) on the surfaces of micro-dielectric barrier discharge (DBD) plasma-treated ZnO nanoparticles. The microstructure and physical properties of ZnO@CA nanoparticles were characterized by field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), infrared spectroscopy, and steady state spectroscopic methods. The antioxidant activity of ZnO@CA nanoparticles was evaluated using an ABTS (3-ethyl-benzothiazoline-6-sulfonic acid) radical cation decolorization assay. ZnO@CA nanoparticles exhibited robust antioxidant activity. Moreover, ZnO@CA nanoparticles showed strong antibacterial activity against Gram-positive bacteria (Staphylococcus aureus) including resistant bacteria such as methicillin-resistant S. aureus and against Gram-negative bacteria (Escherichia coli). Although Gram-negative bacteria appeared to be more resistant to ZnO@CA nanoparticles than Gram-positive bacteria, the antibacterial activity of ZnO@CA nanoparticles was dependent on particle concentration. The antioxidant and antibacterial activity of ZnO@CA may be useful for various biomedical and nanoindustrial applications. Full article
(This article belongs to the Special Issue Frontiers in Toxicity and Functionalization of Nanomaterials)
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Open AccessArticle Optimized Photodynamic Therapy with Multifunctional Cobalt Magnetic Nanoparticles
by , , , , and
Nanomaterials 2017, 7(6), 144; doi:10.3390/nano7060144
Received: 2 May 2017 / Revised: 24 May 2017 / Accepted: 7 June 2017 / Published: 10 June 2017
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Abstract
Photodynamic therapy (PDT) has been adopted as a minimally invasive approach for the localized treatment of superficial tumors, representing an improvement in the care of cancer patients. To improve the efficacy of PDT, it is important to first select an optimized nanocarrier and
[...] Read more.
Photodynamic therapy (PDT) has been adopted as a minimally invasive approach for the localized treatment of superficial tumors, representing an improvement in the care of cancer patients. To improve the efficacy of PDT, it is important to first select an optimized nanocarrier and determine the influence of light parameters on the photosensitizing agent. In particular, much more knowledge concerning the importance of fluence and exposure time is required to gain a better understanding of the photodynamic efficacy. In the present study, we synthesized novel folic acid-(FA) and hematoporphyrin (HP)-conjugated multifunctional magnetic nanoparticles (CoFe2O4-HPs-FAs), which were characterized as effective anticancer reagents for PDT, and evaluated the influence of incubation time and light exposure time on the photodynamic anticancer activities of CoFe2O4-HPs-FAs in prostate cancer cells (PC-3 cells). The results indicated that the same fluence at different exposure times resulted in changes in the anticancer activities on PC-3 cells as well as in reactive oxygen species formation. In addition, an increase of the fluence showed an improvement for cell photo-inactivation. Therefore, we have established optimized conditions for new multifunctional magnetic nanoparticles with direct application for improving PDT for cancer patients. Full article
(This article belongs to the Special Issue Frontiers in Toxicity and Functionalization of Nanomaterials)
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Open AccessArticle Cellular Response to Titanium Dioxide Nanoparticles in Intestinal Epithelial Caco-2 Cells is Dependent on Endocytosis-Associated Structures and Mediated by EGFR
by , and
Nanomaterials 2017, 7(4), 79; doi:10.3390/nano7040079
Received: 3 March 2017 / Revised: 5 April 2017 / Accepted: 5 April 2017 / Published: 7 April 2017
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Abstract
Titanium dioxide (TiO2) is one of the most applied nanomaterials and widely used in food and non-food industries as an additive or coating material (E171). It has been shown that E171 contains up to 37% particles which are smaller than 100
[...] Read more.
Titanium dioxide (TiO2) is one of the most applied nanomaterials and widely used in food and non-food industries as an additive or coating material (E171). It has been shown that E171 contains up to 37% particles which are smaller than 100 nm and that TiO2 nanoparticles (NPs) induce cytotoxicity and inflammation. Using a nuclear factor Kappa-light-chain enhancer of activated B cells (NF-κB) reporter cell line (Caco-2nfkb-RE), Real time polymerase chain reaction (PCR), and inhibition of dynamin and clathrin, it was shown that cellular responses induced by 5 nm and 10 nm TiO2 NPs (nominal size) depends on endocytic processes. As endocytosis is often dependent on the epithelial growth factor receptor (EGFR), further investigations focused on the involvement of EGFR in the uptake of TiO2 NPs: (1) inhibition of EGFR reduced inflammatory markers of the cell (i.e., nuclear factor (NF)-κB activity, mRNA of IL8, CCL20, and CXCL10); and (2) exposure of Caco-2 cells to TiO2 NPs activated the intracellular EGFR cascade beginning with EGFR-mediated extracellular signal-regulated kinases (ERK)1/2, and including transcription factor ELK1. This was followed by the expression of ERK1/2 target genes CCL2 and CXCL3. We concluded that TiO2 NPs enter the cell via EGFR-associated endocytosis, followed by activation of the EGFR/ERK/ELK signaling pathway, which finally induces NF-κB. No changes in inflammatory response are observed in Caco-2 cells exposed to 32 nm and 490 nm TiO2 particles. Full article
(This article belongs to the Special Issue Frontiers in Toxicity and Functionalization of Nanomaterials)
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Open AccessArticle Eu, Gd-Codoped Yttria Nanoprobes for Optical and T1-Weighted Magnetic Resonance Imaging
by , , , , , , , , and
Nanomaterials 2017, 7(2), 35; doi:10.3390/nano7020035
Received: 13 December 2016 / Revised: 26 January 2017 / Accepted: 3 February 2017 / Published: 10 February 2017
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Abstract
Nanoprobes with multimodal functionality have attracted significant interest recently because of their potential applications in nanomedicine. This paper reports the successful development of lanthanide-doped Y2O3 nanoprobes for potential applications in optical and magnetic resonance (MR) imaging. The morphology, structural, and
[...] Read more.
Nanoprobes with multimodal functionality have attracted significant interest recently because of their potential applications in nanomedicine. This paper reports the successful development of lanthanide-doped Y2O3 nanoprobes for potential applications in optical and magnetic resonance (MR) imaging. The morphology, structural, and optical properties of these nanoprobes were characterized by transmission electron microscope (TEM), field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), and photoluminescence (PL). The cytotoxicity test showed that the prepared lanthanide-doped Y2O3 nanoprobes have good biocompatibility. The obvious contrast enhancement in the T1-weighted MR images suggested that these nanoprobes can be used as a positive contrast agent in MRI. In addition, the clear fluorescence images of the L-929 cells incubated with the nanoprobes highlight their potential for optical imaging. Overall, these results suggest that prepared lanthanide-doped Y2O3 nanoprobes can be used for simultaneous optical and MR imaging. Full article
(This article belongs to the Special Issue Frontiers in Toxicity and Functionalization of Nanomaterials)
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