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Nanomaterials 2017, 7(2), 35; doi:10.3390/nano7020035

Eu, Gd-Codoped Yttria Nanoprobes for Optical and T1-Weighted Magnetic Resonance Imaging

Department of Physics and Astronomy, Seoul National University, Seoul 08826, Korea
Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Korea
Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46241, Korea
Department of Radiology, Pusan National University Yangsan Hospital, Yangsan 50612, Korea
Department of Nano Energy Engineering, Pusan National University, Miryang 50463, Korea
Authors to whom correspondence should be addressed.
Academic Editor: Thomas Nann
Received: 13 December 2016 / Revised: 26 January 2017 / Accepted: 3 February 2017 / Published: 10 February 2017
(This article belongs to the Special Issue Frontiers in Toxicity and Functionalization of Nanomaterials)
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Nanoprobes with multimodal functionality have attracted significant interest recently because of their potential applications in nanomedicine. This paper reports the successful development of lanthanide-doped Y2O3 nanoprobes for potential applications in optical and magnetic resonance (MR) imaging. The morphology, structural, and optical properties of these nanoprobes were characterized by transmission electron microscope (TEM), field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), and photoluminescence (PL). The cytotoxicity test showed that the prepared lanthanide-doped Y2O3 nanoprobes have good biocompatibility. The obvious contrast enhancement in the T1-weighted MR images suggested that these nanoprobes can be used as a positive contrast agent in MRI. In addition, the clear fluorescence images of the L-929 cells incubated with the nanoprobes highlight their potential for optical imaging. Overall, these results suggest that prepared lanthanide-doped Y2O3 nanoprobes can be used for simultaneous optical and MR imaging. View Full-Text
Keywords: yttria; nanoprobes; optical imaging; magnetic resonance imaging; cytotoxicity; T1-weighted contrast agent yttria; nanoprobes; optical imaging; magnetic resonance imaging; cytotoxicity; T1-weighted contrast agent

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Atabaev, T.S.; Lee, J.H.; Shin, Y.C.; Han, D.-W.; Choo, K.S.; Jeon, U.B.; Hwang, J.Y.; Yeom, J.A.; Kim, H.-K.; Hwang, Y.-H. Eu, Gd-Codoped Yttria Nanoprobes for Optical and T1-Weighted Magnetic Resonance Imaging. Nanomaterials 2017, 7, 35.

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