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Nanomaterials 2017, 7(6), 148;

Antioxidant Potential and Antibacterial Efficiency of Caffeic Acid-Functionalized ZnO Nanoparticles

Department of Electrical & Biological Physics, Kwangwoon University, 20 Kwangwoongil, Nowon-gu, Seoul 01897, Korea
Department of Medical Engineering, Dongguk University College of Medicine, Gyeonggi-do 10326, Korea
Department of Chemistry, Gangneung-Wonju National University, Gangneung 25457, Korea
Department of Chemistry, Chosun University, Gwangju 61452, Korea
Authors to whom correspondence should be addressed.
Received: 2 May 2017 / Revised: 13 June 2017 / Accepted: 14 June 2017 / Published: 16 June 2017
(This article belongs to the Special Issue Frontiers in Toxicity and Functionalization of Nanomaterials)
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We report a novel zinc oxide (ZnO) nanoparticle with antioxidant properties, prepared by immobilizing the antioxidant 3-(3,4-dihydroxyphenyl)-2-propenoic acid (caffeic acid, CA) on the surfaces of micro-dielectric barrier discharge (DBD) plasma-treated ZnO nanoparticles. The microstructure and physical properties of ZnO@CA nanoparticles were characterized by field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), infrared spectroscopy, and steady state spectroscopic methods. The antioxidant activity of ZnO@CA nanoparticles was evaluated using an ABTS (3-ethyl-benzothiazoline-6-sulfonic acid) radical cation decolorization assay. ZnO@CA nanoparticles exhibited robust antioxidant activity. Moreover, ZnO@CA nanoparticles showed strong antibacterial activity against Gram-positive bacteria (Staphylococcus aureus) including resistant bacteria such as methicillin-resistant S. aureus and against Gram-negative bacteria (Escherichia coli). Although Gram-negative bacteria appeared to be more resistant to ZnO@CA nanoparticles than Gram-positive bacteria, the antibacterial activity of ZnO@CA nanoparticles was dependent on particle concentration. The antioxidant and antibacterial activity of ZnO@CA may be useful for various biomedical and nanoindustrial applications. View Full-Text
Keywords: multifunctional nanoparticle; antioxidant activity; antibacterial activity; caffeic acid; ZnO multifunctional nanoparticle; antioxidant activity; antibacterial activity; caffeic acid; ZnO

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Choi, K.-H.; Nam, K.C.; Lee, S.-Y.; Cho, G.; Jung, J.-S.; Kim, H.-J.; Park, B.J. Antioxidant Potential and Antibacterial Efficiency of Caffeic Acid-Functionalized ZnO Nanoparticles. Nanomaterials 2017, 7, 148.

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