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Nanomaterials 2017, 7(6), 148; doi:10.3390/nano7060148

Antioxidant Potential and Antibacterial Efficiency of Caffeic Acid-Functionalized ZnO Nanoparticles

1
Department of Electrical & Biological Physics, Kwangwoon University, 20 Kwangwoongil, Nowon-gu, Seoul 01897, Korea
2
Department of Medical Engineering, Dongguk University College of Medicine, Gyeonggi-do 10326, Korea
3
Department of Chemistry, Gangneung-Wonju National University, Gangneung 25457, Korea
4
Department of Chemistry, Chosun University, Gwangju 61452, Korea
*
Authors to whom correspondence should be addressed.
Received: 2 May 2017 / Revised: 13 June 2017 / Accepted: 14 June 2017 / Published: 16 June 2017
(This article belongs to the Special Issue Frontiers in Toxicity and Functionalization of Nanomaterials)
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Abstract

We report a novel zinc oxide (ZnO) nanoparticle with antioxidant properties, prepared by immobilizing the antioxidant 3-(3,4-dihydroxyphenyl)-2-propenoic acid (caffeic acid, CA) on the surfaces of micro-dielectric barrier discharge (DBD) plasma-treated ZnO nanoparticles. The microstructure and physical properties of ZnO@CA nanoparticles were characterized by field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), infrared spectroscopy, and steady state spectroscopic methods. The antioxidant activity of ZnO@CA nanoparticles was evaluated using an ABTS (3-ethyl-benzothiazoline-6-sulfonic acid) radical cation decolorization assay. ZnO@CA nanoparticles exhibited robust antioxidant activity. Moreover, ZnO@CA nanoparticles showed strong antibacterial activity against Gram-positive bacteria (Staphylococcus aureus) including resistant bacteria such as methicillin-resistant S. aureus and against Gram-negative bacteria (Escherichia coli). Although Gram-negative bacteria appeared to be more resistant to ZnO@CA nanoparticles than Gram-positive bacteria, the antibacterial activity of ZnO@CA nanoparticles was dependent on particle concentration. The antioxidant and antibacterial activity of ZnO@CA may be useful for various biomedical and nanoindustrial applications. View Full-Text
Keywords: multifunctional nanoparticle; antioxidant activity; antibacterial activity; caffeic acid; ZnO multifunctional nanoparticle; antioxidant activity; antibacterial activity; caffeic acid; ZnO
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Choi, K.-H.; Nam, K.C.; Lee, S.-Y.; Cho, G.; Jung, J.-S.; Kim, H.-J.; Park, B.J. Antioxidant Potential and Antibacterial Efficiency of Caffeic Acid-Functionalized ZnO Nanoparticles. Nanomaterials 2017, 7, 148.

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