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Nanomaterials 2017, 7(8), 216; doi:10.3390/nano7080216

Toxicity and T2-Weighted Magnetic Resonance Imaging Potentials of Holmium Oxide Nanoparticles

Department of Physics and Astronomy, Seoul National University, Seoul 08826, Korea
Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46241, Korea
Authors to whom correspondence should be addressed.
Received: 29 June 2017 / Revised: 15 July 2017 / Accepted: 2 August 2017 / Published: 7 August 2017
(This article belongs to the Special Issue Frontiers in Toxicity and Functionalization of Nanomaterials)
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In recent years, paramagnetic nanoparticles (NPs) have been widely used for magnetic resonance imaging (MRI). This paper reports the fabrication and toxicity evaluation of polyethylene glycol (PEG)-functionalized holmium oxide (Ho2O3) NPs for potential T2-weighted MRI applications. Various characterization techniques were used to examine the morphology, structure and chemical properties of the prepared PEG–Ho2O3 NPs. MRI relaxivity measurements revealed that PEG–Ho2O3 NPs could generate a strong negative contrast in T2-weighted MRI. The pilot cytotoxicity experiments showed that the prepared PEG–Ho2O3 NPs are biocompatible at concentrations less than 16 μg/mL. Overall, the prepared PEG–Ho2O3 NPs have potential applications for T2-weighted MRI imaging. View Full-Text
Keywords: holmium oxide; paramagnetic nanoparticles; T2-weighted magnetic resonance imaging; toxicity holmium oxide; paramagnetic nanoparticles; T2-weighted magnetic resonance imaging; toxicity

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Atabaev, T.S.; Shin, Y.C.; Song, S.-J.; Han, D.-W.; Hong, N.H. Toxicity and T2-Weighted Magnetic Resonance Imaging Potentials of Holmium Oxide Nanoparticles. Nanomaterials 2017, 7, 216.

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