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Nanomaterials 2017, 7(6), 144; doi:10.3390/nano7060144

Optimized Photodynamic Therapy with Multifunctional Cobalt Magnetic Nanoparticles

1
Department of Electrical & Biological Physics, Kwangwoon University, Nowon-gu, Seoul 139-701, Korea
2
Department of Medical Engineering, Dongguk University College of Medicine, Gyeonggi-do 10326, Korea
3
Department of Chemistry, Gangneung-Wonju National University, Gangneung 210-702, Korea
*
Authors to whom correspondence should be addressed.
Received: 2 May 2017 / Revised: 24 May 2017 / Accepted: 7 June 2017 / Published: 10 June 2017
(This article belongs to the Special Issue Frontiers in Toxicity and Functionalization of Nanomaterials)
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Abstract

Photodynamic therapy (PDT) has been adopted as a minimally invasive approach for the localized treatment of superficial tumors, representing an improvement in the care of cancer patients. To improve the efficacy of PDT, it is important to first select an optimized nanocarrier and determine the influence of light parameters on the photosensitizing agent. In particular, much more knowledge concerning the importance of fluence and exposure time is required to gain a better understanding of the photodynamic efficacy. In the present study, we synthesized novel folic acid-(FA) and hematoporphyrin (HP)-conjugated multifunctional magnetic nanoparticles (CoFe2O4-HPs-FAs), which were characterized as effective anticancer reagents for PDT, and evaluated the influence of incubation time and light exposure time on the photodynamic anticancer activities of CoFe2O4-HPs-FAs in prostate cancer cells (PC-3 cells). The results indicated that the same fluence at different exposure times resulted in changes in the anticancer activities on PC-3 cells as well as in reactive oxygen species formation. In addition, an increase of the fluence showed an improvement for cell photo-inactivation. Therefore, we have established optimized conditions for new multifunctional magnetic nanoparticles with direct application for improving PDT for cancer patients. View Full-Text
Keywords: photodynamic therapy; optimized nano-carrier; multifunctional magnetic nanoparticle; fluence; anticancer activity; prostate cancer cell photodynamic therapy; optimized nano-carrier; multifunctional magnetic nanoparticle; fluence; anticancer activity; prostate cancer cell
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Choi, K.-H.; Nam, K.C.; Kim, U.-H.; Cho, G.; Jung, J.-S.; Park, B.J. Optimized Photodynamic Therapy with Multifunctional Cobalt Magnetic Nanoparticles. Nanomaterials 2017, 7, 144.

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