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Special Issue "Conjugate vaccines from carbohydrate antigens"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: 31 May 2018

Special Issue Editors

Guest Editor
Dr. Paul Kovac

NIDDK, LBC, National Institutes of Health, Bethesda, MD 20892-0815, USA
Website | E-Mail
Phone: 301-496-3569
Interests: organic chemistry; carbohydrate chemistry; synthetic oligosaccharides; development of conjugate vaccines from synthetic and bacterial carbohydrate antigens
Guest Editor
Dr. Peng Xu

NIDDK, LBC, National Institutes of Health, Bethesda, MD 20892-0815, USA
Website | E-Mail
Interests: neoglycoconjugate vaccine; conjugation chemistry; chemical glycosylation; oligosaccharide synthesis; lipopolysaccharide; O-specific polysaccharide
Guest Editor
Dr. Helene Pfister

NIDDK, LBC, National Institutes of Health, Bethesda, MD 20892-0815, USA
Website | E-Mail
Interests: carbohydrate chemistry; oligosaccharides synthesis; conjugation chemistry; glycoproteins; glycopolymers; glycoconjugate vaccines

Special Issue Information

Dear Colleagues,

Vaccines are one of the most cost-effective way to control infectious diseases. In addition to protein antigens, cell surface carbohydrates are widely used as antigenic components of vaccines. Since the preparation and clinical use of the first carbohydrate–protein conjugate vaccine in the 1980s, the advantages of this class of vaccines, such as longer shelf life and protective immunity, fewer undesirable side-effects, and better protection in children, have been largely recognized. Glycoconjugate vaccines are composed of carbohydrate antigens, covalently linked to a carrier moiety, usually a non-toxic protein. The carbohydrate moiety is normally an oligosaccharide or polysaccharide of bacterial origins. However, several glycoconjugate vaccines from synthetic oligosaccharides are in development. While immunogenic proteins, such as tetanus toxoid are generally used as carriers of antigens, recent advances in the field showed the potential of immunogenic peptides for the same purpose.

This Special Issue is dedicated to the design, synthesis, and antigenicity/immunogenicity studies of glycoconjugate vaccines. In addition, we welcome contributions on conjugation methodology, synthesis of conjugation-ready oligosaccharides related to protective antigens, and purification and characterization of bacterial polysaccharides.

Dr. Paul Kovac
Dr. Peng Xu
Dr. Helene Pfister
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glycoconjugates
  • neoglycoconjugate
  • conjugation methodology
  • immunogens
  • carbohydrate antigens
  • bacterial carbohydrates
  • vaccines

Published Papers

This special issue is now open for submission.
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