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Molecules 2018, 23(6), 1340; https://doi.org/10.3390/molecules23061340

Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines

1
Technical R&D, GSK Vaccines, 53100 Siena, Italy
2
Preclinical R&D, GSK Vaccines, 53100 Siena, Italy
3
External R&D, GSK Vaccines, 53100 Siena, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Paul Kovac, Peng Xu and Helene Pfister
Received: 8 May 2018 / Revised: 21 May 2018 / Accepted: 30 May 2018 / Published: 2 June 2018
(This article belongs to the Special Issue Conjugate Vaccines from Carbohydrate Antigens)
Full-Text   |   PDF [640 KB, uploaded 8 June 2018]   |  

Abstract

The incidence of infectious diseases caused by several bacterial pathogens such as Haemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitidis, has been dramatically reduced over the last 25 years through the use of glycoconjugate vaccines. The structures of the bacterial capsular polysaccharide (CPS) antigens, extracted and purified from microbial cultures and obtained with very high purity, show that many of them are decorated by O-acetyl groups. While these groups are often considered important for the structural identity of the polysaccharides, they play a major role in the functional immune response to some vaccines such as meningococcal serogroup A and Salmonella typhi Vi, but do not seem to be important for many others, such as meningococcal serogroups C, W, Y, and type III Group B Streptococcus. This review discusses the O-acetylation status of CPSs and its role in the immunological responses of these antigens. View Full-Text
Keywords: bacterial vaccines; conjugate vaccines; carbohydrate antigens; O-acetylation bacterial vaccines; conjugate vaccines; carbohydrate antigens; O-acetylation
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Berti, F.; De Ricco, R.; Rappuoli, R. Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines. Molecules 2018, 23, 1340.

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