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Special Issue "Stereogenic Centers"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: 30 July 2018

Special Issue Editor

Guest Editor
Dr. Alejandro Baeza Carratalá

Universitat d'Alacant, Institute of Organic Synthesis, Alicante, Spain
Website | E-Mail
Interests: asymmetric catalysis; green chemistry; organocatalysis; metal catalysis

Special Issue Information

Dear Colleagues,

The importance of having access to chiral molecules is a well-known fact for the scientific community. This is due to the fact that most of the biological activity that some molecules possess is associated to one of the all-possible enantiomers, which can interact differentially with chiral recognition entities, triggering distinct biochemical responses.

It is not surprising then that different methodologies have been developed in the last century, within the frame of so-called asymmetric synthesis, in order to tackle the challenging task of constructing such chiral compounds, as most of these strategies are based on the construction of stereogenic centers starting from racemic and/or pro-chiral compounds.

Thus, the aim of this Special Issue is to gather recent developments in the establishment of stereogenic centers in organic molecules. Therefore, asymmetric synthesis, kinetic resolutions, asymmetric catalysis (metal-, organo- and biocatalysis), among other strategies, as well as studies that help in the understanding of the mechanism behind these processes will be covered in this Special Issue.

Dr. Alejandro Baeza Carratalá
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Chirality
  • Stereogenic Centers
  • Asymmetric Synthesis
  • Asymmetric Catalysis
  • Enantiomers

Published Papers (2 papers)

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Research

Open AccessFeature PaperCommunication Catalytic Enantioselective Addition of Organozirconium Reagents to Aldehydes
Molecules 2018, 23(4), 961; doi:10.3390/molecules23040961 (registering DOI)
Received: 6 April 2018 / Revised: 17 April 2018 / Accepted: 17 April 2018 / Published: 20 April 2018
PDF Full-text (3529 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
A catalytic enantioselective addition reaction of alkylzirconium species to aromatic aldehydes is reported. The reaction, facilitated by a chiral nonracemic diol ligand complex with Ti(OiPr)4, proceeds under mild and convenient conditions, and no premade organometallic reagents are required since
[...] Read more.
A catalytic enantioselective addition reaction of alkylzirconium species to aromatic aldehydes is reported. The reaction, facilitated by a chiral nonracemic diol ligand complex with Ti(OiPr)4, proceeds under mild and convenient conditions, and no premade organometallic reagents are required since the alkylzirconium nucleophiles are generated in situ by hydrozirconation of alkenes with the Schwartz reagent. The methodology is compatible with functionalized nucleophiles and a broad range of aromatic aldehydes. Full article
(This article belongs to the Special Issue Stereogenic Centers)
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Open AccessArticle Asymmetric Conjugate Addition of α,α-Disubstituted Aldehydes to Nitroalkenes Organocatalyzed by Chiral Monosalicylamides from trans-Cyclohexane-1,2-Diamines
Molecules 2018, 23(1), 141; doi:10.3390/molecules23010141
Received: 25 December 2017 / Revised: 8 January 2018 / Accepted: 9 January 2018 / Published: 11 January 2018
PDF Full-text (1803 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Primary amine-salicylamides derived from chiral trans-cyclohexane-1,2-diamines are used as organocatalysts for the enantioselective conjugate addition of α,α-disubstituted aldehydes to arylated and heteroarylated nitroalkenes. The reaction is performed in the presence of 4-dimethylaminopyridine as an additive in dichloromethane as a solvent at room
[...] Read more.
Primary amine-salicylamides derived from chiral trans-cyclohexane-1,2-diamines are used as organocatalysts for the enantioselective conjugate addition of α,α-disubstituted aldehydes to arylated and heteroarylated nitroalkenes. The reaction is performed in the presence of 4-dimethylaminopyridine as an additive in dichloromethane as a solvent at room temperature. The corresponding enantioenriched γ-nitroaldehydes are obtained with enantioselectivities up to 95%. Theoretical calculations are used to justify the reasons of the stereoinduction. Full article
(This article belongs to the Special Issue Stereogenic Centers)
Figures

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Author: Dr. Wei Zhang
Affiliation: Department of Chemistry, University of Massachusetts, , Boston, MA, USA
Tentative title: "Recyclable Fluorous Organocatalyst-Promoted Asymmetric Michael/Michael Additions for Asymmetric Synthesis of Substituted Cyclohexanones"

Author: Xiang Wu
Affiliation: Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, China
Tentative tile: Asymmetric Oxidative Formal Aza-Diels-Alder Reaction for the Synthesis of Indoloquinolizidines.

Author: Yasuhiro Kawnami
Affiliation: Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, Miki-cho, Kagawa 761-0795, Japan
Tentative title: "Practical enantioselective reduction of ketones using an oxazaborolidin catalyst generated in situ from a chiral lactam alcohol and borane"

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