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Special Issue "Solid Phase Synthesis"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: 15 May 2018

Special Issue Editor

Guest Editor
Prof. Viktor Krchnak

1. Department of Chemistry and Biochemistry, 251 Nieuwland Science Center, University of Notre Dame, Notre Dame, Indiana 46556, USA
2. Department of Organic Chemistry, Palacký University, 17. Listopadu 12, 771 46 Olomouc, Czech Republic
Website | E-Mail
Phone: 574-631-5113
Interests: solid-phase synthesis; combinatorial chemistry; heterocycles; chiral molecular scaffold; iminium chemistry

Special Issue Information

Dear colleagues,

This Special Issue of Molecules is dedicated to “Solid-Phase Synthesis”. The concept of solid-phase (SP) peptide synthesis was revealed by Bruce Merrifield in 1963 and its potential for general organic chemistry was soon recognized. However, it was not until the onset of combinatorial chemistry in early 1990s when the application of SP organic synthesis started to flourish.

Today, SP synthesis is widely used particularly in the area of drug discovery. Critical advantages of SP synthesis include very efficient isolation of intermediates by washing resin beads. Consequently, high boiling solvents, such as DMF and DMSO, can be used beneficially without the need to evaporate them.

Drug discovery efforts benefited from the time efficient synthesis of compounds decks for high throughput screening as well as dedicated libraries for hit/lead optimization. Diversity oriented synthesis (DOS) that was mainly focused on synthesis of structurally dissimilar compounds has now shifted to biology oriented synthesis (BIOS) focused on the design of structures resembling natural products, including complex chiral molecular scaffolds with three-dimensional architecture.

This Special Issue will provide an opportunity to publish research results dedicated to all aspects of SP synthesis including, but not limited to, development of new chemical transformations, new resins, linkers, methodology, catalyst development, combinatorial synthesis, solid-phase reagents, synthesis of drug-like molecules, peptides, preparation of compound decks for high throughput screening, etc.

Prof. Viktor Krchnak
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • development of new chemical transformations
  • new resins
  • linkers
  • methodology
  • catalyst development
  • combinatorial synthesis
  • solid-phase reagents
  • synthesis of drug-like molecules
  • peptides
  • preparation of compound decks for high throughput screening

Published Papers

This special issue is now open for submission.
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