Special Issue "High-throughput Screening"
Deadline for manuscript submissions: closed (15 January 2010)
Dr. Florian Hollfelder
Department of Biochemistry, 80 Tennis Court Road, 3.84 Sanger Building, GB, Cambridge CB2 1GA, United Kingdom
Phone: +44 1223 766048 (lab)
Fax: +44 1223 766002
In addition to being the workhorse of the pharmaceutical industry, high-throughput screening is becoming a more and more central experimental approach in diverse research areas ranging from genomics, proteomics to systems and synthetic biology. The idea of characterizing entire ensembles of genes, proteins, small molecule or organismal repertoires is attractive when the complexity of a system defies straightforward understanding and rational manipulation.
In contrast to selection approaches that obey a ‘first-past-the-post’ logic, screening quantitatively measures one or more experimental parameters for the entire library. The knowledge about an entire library may give rise to structure-activity relationships and allows a more informed choice about which molecules to select e.g. for further rounds of evolutionary improvements.
Accessibility of these approaches to a wider circle of experimentalists has been driven by technological advances, specifically miniaturization and advances in detection systems. This issue will focus on the technical advances that give insight into property spaces and combine it with an outlook towards the potential of such massively parallel experimentation in Chemistry and Biology.
Florian Hollfelder, Ph.D.
All papers should be submitted to firstname.lastname@example.org with copy to the guest editor. To be published continuously until the deadline and papers will be listed together at the special websites.
Submitted papers should not have been previously published nor be currently under consideration for publication elsewhere. All papers are refereed through a peer review process. A guide for authors, sample copies and other relevant information for submitting papers are available on the Instructions for Authors page. Molecules is an international peer-reviewed monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a paper. Article Processing Charges (APC) are 800 CHF per paper and additional English correction fees (250 CHF) will be added in certain cases (1050CHF per paper for those papers that require extensive additional formatting and/or English corrections) for paper submitted before 31 December 2009. Starting 1 January 2010, Article Processing Charges are of 1400 CHF per accepted article for Molecules.
- DNA library
- Encoding /decoding
- In vitro compartmentalisation
- Systems biology
- Synthetic biology
Article: Spectroscopic Analyses of the Biofuels-Critical Phytochemical Coniferyl Alcohol and Its Enzyme-Catalyzed Oxidation Products
Molecules 2009, 14(11), 4758-4778; doi:10.3390/molecules14114758
Received: 21 October 2006; in revised form: 16 November 2006 / Accepted: 19 November 2009 / Published: 23 November 2009| Download PDF Full-text (564 KB)
Molecules 2010, 15(1), 215-225; doi:10.3390/molecules15010215
Received: 6 November 2009; in revised form: 17 December 2009 / Accepted: 31 December 2009 / Published: 7 January 2010| Download PDF Full-text (595 KB) | Correction
Molecules 2010, 15(3), 1645-1667; doi:10.3390/molecules15031645
Received: 14 January 2010; in revised form: 23 February 2010 / Accepted: 8 March 2010 / Published: 11 March 2010| Download PDF Full-text (596 KB)
Molecules 2010, 15(3), 1690-1704; doi:10.3390/molecules15031690
Received: 25 January 2010; in revised form: 20 February 2010 / Accepted: 8 March 2010 / Published: 12 March 2010| Download PDF Full-text (697 KB)
Review: Automation in the High-throughput Selection of Random Combinatorial Libraries—Different Approaches for Select Applications
Molecules 2010, 15(4), 2478-2490; doi:10.3390/molecules15042478
Received: 10 February 2010; in revised form: 30 March 2010 / Accepted: 6 April 2010 / Published: 8 April 2010| Download PDF Full-text (279 KB)
Article: High-Throughput Behavioral Screens: the First Step towards Finding Genes Involved in Vertebrate Brain Function Using Zebrafish
Molecules 2010, 15(4), 2609-2622; doi:10.3390/molecules15042609
Received: 9 February 2010; in revised form: 26 March 2010 / Accepted: 7 April 2010 / Published: 12 April 2010| Download PDF Full-text (199 KB)
Review: Assay Format as a Critical Success Factor for Identification of Novel Inhibitor Chemotypes of Tissue-Nonspecific Alkaline Phosphatase from High-Throughput Screening
Molecules 2010, 15(5), 3010-3037; doi:10.3390/molecules15053010
Received: 20 January 2010; in revised form: 18 March 2010 / Accepted: 22 April 2010 / Published: 27 April 2010| Download PDF Full-text (965 KB)
Molecules 2010, 15(8), 5525-5546; doi:10.3390/molecules15085525
Received: 11 June 2010; in revised form: 20 July 2010 / Accepted: 4 August 2010 / Published: 10 August 2010| Download PDF Full-text (846 KB)
Last update: 26 September 2012