Special Issue "High-throughput Screening"

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A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Molecular Diversity".

Deadline for manuscript submissions: closed (15 January 2010)

Special Issue Editor

Guest Editor
Dr. Florian Hollfelder
Department of Biochemistry, 80 Tennis Court Road, 3.84 Sanger Building, GB, Cambridge CB2 1GA, United Kingdom
Website: http://www.bioc.cam.ac.uk/uto/hollfelder.html
E-Mail: fh111@cam.ac.uk
Phone: +44 1223 766048 (lab)
Fax: +44 1223 766002

Special Issue Information

Dear Colleagues,

In addition to being the workhorse of the pharmaceutical industry, high-throughput screening is becoming a more and more central experimental approach in diverse research areas ranging from genomics, proteomics to systems and synthetic biology. The idea of characterizing entire ensembles of genes, proteins, small molecule or organismal repertoires is attractive when the complexity of a system defies straightforward understanding and rational manipulation.

In contrast to selection approaches that obey a ‘first-past-the-post’ logic, screening quantitatively measures one or more experimental parameters for the entire library. The knowledge about an entire library may give rise to structure-activity relationships and allows a more informed choice about which molecules to select e.g. for further rounds of evolutionary improvements.

Accessibility of these approaches to a wider circle of experimentalists has been driven by technological advances, specifically miniaturization and advances in detection systems. This issue will focus on the technical advances that give insight into property spaces and combine it with an outlook towards the potential of such massively parallel experimentation in Chemistry and Biology.

Florian Hollfelder, Ph.D.
Guest Editor

Keywords

  • DNA library
  • Encoding /decoding
  • In vitro compartmentalisation
  • Systems biology
  • Synthetic biology

Published Papers (8 papers)

by
Molecules 2010, 15(8), 5525-5546; doi:10.3390/molecules15085525
Received: 11 June 2010; in revised form: 20 July 2010 / Accepted: 4 August 2010 / Published: 10 August 2010
Show/Hide Abstract | Cited by 11 | PDF Full-text (846 KB)
abstract graphic

by ,  and
Molecules 2010, 15(5), 3010-3037; doi:10.3390/molecules15053010
Received: 20 January 2010; in revised form: 18 March 2010 / Accepted: 22 April 2010 / Published: 27 April 2010
Show/Hide Abstract | Cited by 7 | PDF Full-text (965 KB)

by
Molecules 2010, 15(4), 2609-2622; doi:10.3390/molecules15042609
Received: 9 February 2010; in revised form: 26 March 2010 / Accepted: 7 April 2010 / Published: 12 April 2010
Show/Hide Abstract | Cited by 49 | PDF Full-text (199 KB)

by ,  and
Molecules 2010, 15(4), 2478-2490; doi:10.3390/molecules15042478
Received: 10 February 2010; in revised form: 30 March 2010 / Accepted: 6 April 2010 / Published: 8 April 2010
Show/Hide Abstract | Cited by 2 | PDF Full-text (279 KB)

by , , , , , , , , ,  and
Molecules 2010, 15(3), 1690-1704; doi:10.3390/molecules15031690
Received: 25 January 2010; in revised form: 20 February 2010 / Accepted: 8 March 2010 / Published: 12 March 2010
Show/Hide Abstract | Cited by 3 | PDF Full-text (697 KB)

by , , ,  and
Molecules 2010, 15(3), 1645-1667; doi:10.3390/molecules15031645
Received: 14 January 2010; in revised form: 23 February 2010 / Accepted: 8 March 2010 / Published: 11 March 2010
Show/Hide Abstract | PDF Full-text (596 KB)
abstract graphic

by ,  and
Molecules 2010, 15(1), 215-225; doi:10.3390/molecules15010215
Received: 6 November 2009; in revised form: 17 December 2009 / Accepted: 31 December 2009 / Published: 7 January 2010
Show/Hide Abstract | Cited by 19 | PDF Full-text (595 KB) | Supplementary Files

by , ,  and
Molecules 2009, 14(11), 4758-4778; doi:10.3390/molecules14114758
Received: 21 October 2006; in revised form: 16 November 2006 / Accepted: 19 November 2009 / Published: 23 November 2009
Show/Hide Abstract | PDF Full-text (564 KB)

Last update: 27 February 2014

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