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Molecules 2010, 15(4), 2478-2490; doi:10.3390/molecules15042478

Automation in the High-throughput Selection of Random Combinatorial Libraries—Different Approaches for Select Applications

1
Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 63-73, 14195 Berlin, Germany
2
Institute for Chemistry/ Biochemistry, Free University Berlin, Thielallee 63, 14195 Berlin, Germany
*
Author to whom correspondence should be addressed.
Received: 10 February 2010 / Revised: 30 March 2010 / Accepted: 6 April 2010 / Published: 8 April 2010
(This article belongs to the Special Issue High-throughput Screening)
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Abstract

Automation in combination with high throughput screening methods has revolutionised molecular biology in the last two decades. Today, many combinatorial libraries as well as several systems for automation are available. Depending on scope, budget and time, a different combination of library and experimental handling might be most effective. In this review we will discuss several concepts of combinatorial libraries and provide information as what to expect from these depending on the given context.
Keywords: phage display; SELEX; automation; random combinatorial library; in vitro evolution phage display; SELEX; automation; random combinatorial library; in vitro evolution
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Glökler, J.; Schütze, T.; Konthur, Z. Automation in the High-throughput Selection of Random Combinatorial Libraries—Different Approaches for Select Applications. Molecules 2010, 15, 2478-2490.

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