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Special Issue "High Throughput Screening Ⅱ"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: 31 January 2019

Special Issue Editors

Guest Editor
Dr. Anton Simeonov

National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, United States
Website | E-Mail
Interests: translational research; high-throughput screening; assay development; laboratory automation
Guest Editor
Prof. Zhihao Zhuang

Department of Chemistry and Biochemistry, University of Delaware, United States
Website | E-Mail
Interests: post-translational modification; ubiquitination; activity-based probes; enzymology; DNA damage tolerance; nucleic acid chemistry; high throughput screening; small molecule inhibitor; cancer, neurodegeneration

Special Issue Information

Dear Colleagues,

In the last decade, we have witnessed the increased popularity of high throughput screening (HTS) in academia for tool compound development and drug discovery. This has been largely fueled by the rapid developments at many fronts of biology, and the novel targets identified through these efforts. The creation of academic screening centers and the NIH Molecular Libraries Roadmap Initiative have spearheaded the effort and provided crucial infrastructural and technical support to many academic labs engaged in probe development and unravelment of fundamental biology using an HTS approach. With the continued growth of the academic drug discovery effort and the increased demands of high quality tool compounds, the interest in HTS will continue to increase among academic researchers. We thus would like to put together this Special Issue on HTS to highlight the most recent development in the many different fronts of HTS research, encompassing novel assay formats, new targets and screening technologies. We invite the submission of full articles and communications reporting recent work on biochemical, cell-based, phenotypic, and targeted screening. We also welcome timely reviews on the above topics and any other areas of HTS that will capture the interest and imagination of the HTS community.

We thank in advance for your contribution to this Special Issue on HTS.

Dr. Anton Simeonov
Prof. Zhihao Zhuang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • high-throughput screening
  • screening methods
  • screening data analysis
  • novel targets
  • assay artifacts
  • compound profiling
  • assay development
  • cheminformatics
  • laboratory automation

Related Special Issue

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Genome-wide microRNA profiling in the sacculus rotundus tissue of rabbit by high-throughput sequencing approach
Author: Shiyi Chen
Affiliation: Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China
Abstract: Rabbit is a widely used animal model for biomedical researches because of the phylogenetic relationship to human beings, short vital cycle, less aggressive behavior and other advantages. However, our basic researches on the genomic biology of rabbit have obviously lagged far behind. The sacculus rotundus is a specific gut-associated lymphoid tissue in rabbit and plays important roles for host immunity. In the present study, we first employed high-throughput sequencing approach to reveal the genome-wide microRNAs among more than 40 rabbits. Our results provide a set of reference microRNAs and hence facilitate the researches on biological implications of microRNAs in rabbit.
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