Special Issue "Photoresponsive Drugs"
Deadline for manuscript submissions: closed (15 September 2016)
With the advent of theranostics and personalized medicine, chemists are challenged to provide molecular solutions for locally activated pharmacological treatment. Supported by recent developments in molecular medical imaging, which provide information on the localization of the pathology, one can envision fascinating prospects for focusing the activity of the drug on the disease spot. Bioactive molecules (drugs), whose activity can be externally regulated, could help to tackle important societal problems, including drug side-effects, emergence of resistance and environmental toxicity. There is also a need for externally-regulated bioactive molecules in research, where it allows precisely controlled regulation of the activity of receptor ligands, enzyme inhibitors, and others.
In recent years, and thanks to several proof-of-principle studies, light has emerged as a promising external control element for drug activity (photopharmacology). Light is a privileged stimulus, as it is allows for non-invasive treatment and can be delivered with very high spatiotemporal precision and control over intensity and wavelength. Furthermore, photons do not contaminate the patient’s body and have low (wavelength-dependent) cytotoxicity.
The developing field of photoresponsive drugs is in constant need of molecular designs and therapeutic targets. Of crucial importance are also new photoswitches and caging groups, that can be addressed with bio-compatible light of longer wavelengths in one and two-photon processes. Finally, the developments in the delivery of light to tissues, inspired by solutions in photodynamic therapy, are also in high demand. This Special Issue aims at offering the space in which recent research in the above-described topics could be communicated.
Dr. Wiktor Szymański
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- photocaged drugs
- visible and near-IR light photoswitching and uncaging
- light delivery to tissues
- two-photon switching and uncaging of photoactive drugs
- light-controlled drug delivery