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Special Issue "Biology of Reactive Oxygen and Nitrogen Species: Redox Signaling, Metabolic Effects, Cellular Functions and Oxidative Damage"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: 20 April 2018

Special Issue Editors

Guest Editor
Assoc. Prof. Dr. Andrey V. Kozlov

Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, A-1200 Vienna, Austria
Website | E-Mail
Interests: mitochondria; reactive oxygen and nitrogen species; endoplasmic reticulum (-stress); iron metabolism; organ failure; inflammation; hypoxia; critical care diseases
Guest Editor
Assoc. Prof. Dr. Sergey Dikalov

Vanderbilt University, Clinical Pharmacology Department, 2200 Pierce Ave, 558 PRB, Nashville, TN 37232, USA
Website | E-Mail

Special Issue Information

Dear Colleagues,

For a long time, reactive oxygen and nitrogen species (RONS) were considered as deleterious chemically-active molecules causing oxidative damage to nearly all types of biomolecules. More recently, RONS have been discovered as regulators of diverse intracellular processes, such as redox signalling, metabolic processes, and cellular functions. Thus, the biological impact of RONS is a sum of diverse and possibly even opposite effects, which can modulate physiological processes and also contribute to the development of a disease.

Consideration of possible mechanism switching between beneficial and deleterious effects of RONS led to a rather common assumption, that low levels of ROS activate signalling pathways while oxidative stress denotes high levels of ROS. However, numerous reports on the chemistry of RONS show, that molecules jointly named RONS indeed have quite different chemical properties and consequently must have different biological effects. Some of these species are more suitable for physiological reactions, while the others exert predominantly damaging capacity. Thus, the identification of specific RONS occurring in biological systems is as important as the determination of total amount of RONS formed.

This Special Issue will focus on two aspects of RONS biology indicated above. The first one, which considers the links between RONS and diverse cellular/organ functions as well as impact of RONS on clinical outcomes. The second aspect is related to the identification of specific type of RONS involved in the regulation of diverse cellular/organ functions, particular those relevant for development of diseases. Papers addressing both aspects simultaneously will be greatly favored.

Assoc. Prof. Dr. Andrey V. Kozlov
Assoc. Prof. Dr. Sergey Dikalov
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • superoxide radical
  • hydrogen peroxide
  • peroxynitrite
  • mitochondria
  • peroxisome
  • NADPH-oxidase
  • hypoxia
  • inflammation
  • redox signaling
  • gene expression
  • metabolism
  • cellular functions

Published Papers

This special issue is now open for submission.
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