Special Issue "Organic Iodine Chemistry"

Guest Editor
Prof. Dr. Bimal K. Banik
President's Endowed Professor, Science & Engineering, Professor of Chemistry, The University of Texas Pan American, 1201 West University Drive, Edinburg, TX 78539, USA
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Guest Editor
Dr. Hideo Togo
Graduate School of Science, Chiba University, Japan
E-Mail:

Dear Colleagues,

In recent years, a large number of organic reactions have been investigated using molecule iodine-catalyzed and iodine-induced methods. Therefore, many new compounds have been synthesized using molecular iodine. Iodine is an inexpensive weak Lewis acid, non-toxic, and readily available reagent for various organic transformations and yields products with outstanding selectivity with minimum by products. In view of the increasingly expanding field of molecular iodine-mediated reactions and significant attention in this area from academic and industrial scientists, we believe a respectable journal should publish a whole issue on iodine mediated reactions toward the synthesis of important organic compounds under environmentally benign conditions. I am delighted that Molecules have come forward and ask me to take over this responsibility.

The main objective of this issue will be to provide useful information to researchers and students who are interested in the chemistry of iodine and its fascinating role in organic synthesis. Efforts will be made to include not only the synthesis of organic compounds but also to understand the mechanism of iodine-mediated reactions in different solvents including in water.

In summary, I have no doubt that this volume in Molecules will be extremely valuable resource for many groups who are working on organoiodine chemistry.

Prof. Dr. Bimal K. Banik
Hideo Togo, Ph. D.
Guest Editors

Submission

All papers should be submitted to molecules@mdpi.org with copy to the guest editor. To be published continuously until the deadline and papers will be listed together at the special websites.

• iodine
• catalysis
• organic synthesis
• selectivity
• green chemistry and mechanism

Type of Paper: Review
Title: Molecular Iodine in the Synthesis of Chromone-Type Compounds
Authors: Diana C. G. A. Pinto and Artur M. S. Silva*
Affiliation: Chemistry Department & QOPNA, University of Aveiro, Campus de Santiago, 3810 -193 Aveiro, Portugal; Phone: +351 234 370714; Fax: +351 234 370084; E-mail: artur.silva@ua.pt
Abstract: Chromones are an important group of heterocyclic compounds due not only to their important functions in the nature but also to their pharmacological applications. Many efficient syntheses of chromones have been reported through the years but the search for novel methods addressed to the preparation of this type of compounds still remains a relevant topic. Simple and efficient procedures using molecular iodinefor the synthesis of these organic molecules have been reported. The use of catalytic amount of iodine in oxidative cyclizations or helping in photooxidative cyclizations is a well known approach to the preparation of new chromone-type compounds. The purpose of this review is to describe the most relevant work on chromone type compounds using molecular iodine.

Manuscript ID: Molecules-Iodichem-20090721-wuef-ca
Title: Iodine-124: A Promising Iodine Radioisotope for Positron Emission Tomography (PET)
Author: Frank Wuest
Affiliation: Cross Cancer Institute, 11560 University Avenue, Edmonton AB T6G 1Z2, Canada, E-mail: frankwue@cancerboard.ab.ca
Abstract: The use of radiopharmaceuticals for molecular imaging of biochemical and physiological processes in vivo has evolved into an important diagnostic tool in modern nuclear medicine and medical research. Positron emission tomography (PET) is currently the most sophisticated molecular imaging methodology, mainly due the unrivalled high sensitivity allowing study of biochemistry in vivo on the molecular level. Most frequently used radionuclides for PET have relatively short half-lives (e.g. 11C: 20.4 min; 18F: 109.8 min) which may limit synthesis procedures and time frame of PET studies. Iodine-124 (124I, t1/2 = 4.2 d) is an alternative long-lived PET radionuclide attracting increasing interest for long term clinical and small animal PET studies.
The present review will give a survey on the use of 124I as promising PET radionuclide for molecular imaging. The first part describes the production of 124I. The second part will cover basic radiochemistry with 124I focused on the synthesis of 124I-labeled compounds for molecular imaging purposes. The review will be concluded with a summary and an outlook on the future perspectives of using the long-lived positron emitter 124I in the field of organic PET chemistry and molecular imaging.