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Molecules 2010, 15(5), 3211-3227; doi:10.3390/molecules15053211

Bohlmann-Rahtz Cyclodehydration of Aminodienones to Pyridines Using N-Iodosuccinimide

School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, CF10 3AT, UK
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Author to whom correspondence should be addressed.
Received: 22 March 2010 / Accepted: 20 April 2010 / Published: 30 April 2010
(This article belongs to the Special Issue Organic Iodine Chemistry)
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Abstract

Cyclodehydration of Bohlmann-Rahtz aminodienone intermediates using N-iodosuccinimide as a Lewis acid proceeds at low temperature under very mild conditions to give the corresponding 2,3,6-trisubstituted pyridines in high yield and with total regiocontrol.
Keywords: Bohlmann-Rahtz synthesis; cyclization reactions; heterocycles; Lewis acids; pyridines Bohlmann-Rahtz synthesis; cyclization reactions; heterocycles; Lewis acids; pyridines
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Bagley, M.C.; Glover, C. Bohlmann-Rahtz Cyclodehydration of Aminodienones to Pyridines Using N-Iodosuccinimide. Molecules 2010, 15, 3211-3227.

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