Molecules 2010, 15(2), 1082-1088; doi:10.3390/molecules15021082
Communication

Remarkable Iodine-Catalyzed Synthesis of Novel Pyrrole- Bearing N-Polyaromatic β-Lactams

Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX 78541, USA
* Author to whom correspondence should be addressed.
Received: 22 December 2009; in revised form: 8 February 2010 / Accepted: 20 February 2010 / Published: 23 February 2010
(This article belongs to the Special Issue Organic Iodine Chemistry)
PDF Full-text Download PDF Full-Text [165 KB, uploaded 23 February 2010 15:40 CET]
Abstract: Because of their interesting biological properties various methods for the synthesis of substituted pyrroles are described in the literature. However, synthesis of pyrroles fused with a β-lactam ring has not been reported. Our group has demonstrated synthesis and biological evaluation of various β-lactams as anticancer agents. The anticancer activities of these compounds have prompted us to study the synthesis of pyrroles bound to the β-lactams. We have identified an expeditious synthetic method for the preparation of pyrroles fused with β-lactams by reacting 3-amino β-lactams with acetonylacetone in the presence of catalytic amounts (5 mol%) of molecular iodine at room temperature. It has also been discovered that the reaction gives products under domestic and automated microwave oven irradiation. To our knowledge, there are no other prior reports that describe the synthesis of pyrrole-substituted β-lactams.
Keywords: iodine; catalysis; β-lactams; pyrroles

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Bandyopadhyay, D.; Rivera, G.; Salinas, I.; Aguilar, H.; Banik, B.K. Remarkable Iodine-Catalyzed Synthesis of Novel Pyrrole- Bearing N-Polyaromatic β-Lactams. Molecules 2010, 15, 1082-1088.

AMA Style

Bandyopadhyay D, Rivera G, Salinas I, Aguilar H, Banik BK. Remarkable Iodine-Catalyzed Synthesis of Novel Pyrrole- Bearing N-Polyaromatic β-Lactams. Molecules. 2010; 15(2):1082-1088.

Chicago/Turabian Style

Bandyopadhyay, Debasish; Rivera, Gildardo; Salinas, Isabel; Aguilar, Hector; Banik, Bimal K. 2010. "Remarkable Iodine-Catalyzed Synthesis of Novel Pyrrole- Bearing N-Polyaromatic β-Lactams." Molecules 15, no. 2: 1082-1088.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert