Next Article in Journal
Access to Original Vinylic Chlorides in the Quinazoline Series via a Monoelectronic Transfer Reaction Approach
Next Article in Special Issue
Conversion of Aryl Iodides into Aryliodine(III) Dichlorides by an Oxidative Halogenation Strategy Using 30% Aqueous Hydrogen Peroxide in Fluorinated Alcohol
Previous Article in Journal
The Heck Reaction Applied to 1,3- and 1,2-Unsaturated Derivatives, a Way towards Molecular Complexity
Previous Article in Special Issue
An Expeditious Synthesis of N-substituted Pyrroles via Microwave-Induced Iodine-Catalyzed Reactions under Solventless Conditions
Molecules 2010, 15(4), 2686-2718; doi:10.3390/molecules15042686

Iodine-124: A Promising Positron Emitter for Organic PET Chemistry

1 Institute of Radiopharmacy, Research Center Dresden-Rossendorf, Dresden, Germany 2 Department of Physics, University of Alberta, Edmonton, Canada 3 Department of Oncology, University of Alberta, Edmonton, Canada These two authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 5 March 2010 / Revised: 7 April 2010 / Accepted: 9 April 2010 / Published: 13 April 2010
(This article belongs to the Special Issue Organic Iodine Chemistry)
Download PDF [779 KB, uploaded 18 June 2014]


The use of radiopharmaceuticals for molecular imaging of biochemical and physiological processes in vivo has evolved into an important diagnostic tool in modern nuclear medicine and medical research. Positron emission tomography (PET) is currently the most sophisticated molecular imaging methodology, mainly due to the unrivalled high sensitivity which allows for the studying of biochemistry in vivo on the molecular level. The most frequently used radionuclides for PET have relatively short half-lives (e.g. 11C: 20.4 min; 18F: 109.8 min) which may limit both the synthesis procedures and the time frame of PET studies. Iodine-124 (124I, t1/2 = 4.2 d) is an alternative long-lived PET radionuclide attracting increasing interest for long term clinical and small animal PET studies. The present review gives a survey on the use of 124I as promising PET radionuclide for molecular imaging. The first part describes the production of 124I. The second part covers basic radiochemistry with 124I focused on the synthesis of 124I-labeled compounds for molecular imaging purposes. The review concludes with a summary and an outlook on the future prospective of using the long-lived positron emitter 124I in the field of organic PET chemistry and molecular imaging.
Keywords: iodine-124; positron emission tomography (PET); molecular imaging iodine-124; positron emission tomography (PET); molecular imaging
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Koehler, L.; Gagnon, K.; McQuarrie, S.; Wuest, F. Iodine-124: A Promising Positron Emitter for Organic PET Chemistry. Molecules 2010, 15, 2686-2718.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert