Molecules 2010, 15(4), 2686-2718; doi:10.3390/molecules15042686
Review

Iodine-124: A Promising Positron Emitter for Organic PET Chemistry

1 Institute of Radiopharmacy, Research Center Dresden-Rossendorf, Dresden, Germany 2 Department of Physics, University of Alberta, Edmonton, Canada 3 Department of Oncology, University of Alberta, Edmonton, Canada These two authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 5 March 2010; in revised form: 7 April 2010 / Accepted: 9 April 2010 / Published: 13 April 2010
(This article belongs to the Special Issue Organic Iodine Chemistry)
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Abstract: The use of radiopharmaceuticals for molecular imaging of biochemical and physiological processes in vivo has evolved into an important diagnostic tool in modern nuclear medicine and medical research. Positron emission tomography (PET) is currently the most sophisticated molecular imaging methodology, mainly due to the unrivalled high sensitivity which allows for the studying of biochemistry in vivo on the molecular level. The most frequently used radionuclides for PET have relatively short half-lives (e.g. 11C: 20.4 min; 18F: 109.8 min) which may limit both the synthesis procedures and the time frame of PET studies. Iodine-124 (124I, t1/2 = 4.2 d) is an alternative long-lived PET radionuclide attracting increasing interest for long term clinical and small animal PET studies. The present review gives a survey on the use of 124I as promising PET radionuclide for molecular imaging. The first part describes the production of 124I. The second part covers basic radiochemistry with 124I focused on the synthesis of 124I-labeled compounds for molecular imaging purposes. The review concludes with a summary and an outlook on the future prospective of using the long-lived positron emitter 124I in the field of organic PET chemistry and molecular imaging.
Keywords: iodine-124; positron emission tomography (PET); molecular imaging

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MDPI and ACS Style

Koehler, L.; Gagnon, K.; McQuarrie, S.; Wuest, F. Iodine-124: A Promising Positron Emitter for Organic PET Chemistry. Molecules 2010, 15, 2686-2718.

AMA Style

Koehler L, Gagnon K, McQuarrie S, Wuest F. Iodine-124: A Promising Positron Emitter for Organic PET Chemistry. Molecules. 2010; 15(4):2686-2718.

Chicago/Turabian Style

Koehler, Lena; Gagnon, Katherine; McQuarrie, Steve; Wuest, Frank. 2010. "Iodine-124: A Promising Positron Emitter for Organic PET Chemistry." Molecules 15, no. 4: 2686-2718.

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