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Special Issue "Natural Products and Derivatives in Human Disorders"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 20 January 2019

Special Issue Editors

Guest Editor
Prof. Eva E. Rufino-Palomares

University of Granada, Faculty of Sciences. Department of Biochemistry and Molecular I, Granada, Spain
Website | E-Mail
Phone: +34636617261
Interests: natural products; properties and mechanism; anti-cancer and other disorders
Guest Editor
Prof. José Antonio Lupiáñez

University of Granada, Faculty of Sciences. Department of Biochemistry and Molecular Biology I, Granada, Spain
Website | E-Mail
Phone: +34958243089
Interests: cancer biomarkers, triterpenes and derivatives, drug metabolism

Special Issue Information

Dear Colleagues,

Recently, we accepted an invitation to serve as Guest Editors for this Special Issue, " Natural Products and Derivatives in Human Disorders” of the journal Molecules (ISSN 1420-3049 http://www.mdpi.com/journal/molecules) with an impact factor 3.098 (2017) in Biochemistry and Molecular Biology and Chemistry, multidisciplinary areas. In this regard, we would be pleased if you would agree to contribute an original research paper, a short communication, or a focus review to this issue. Provided below is some information that you may find useful in your consideration of this invitation.

This Special Issue aims to collect and disseminate some of the most significant and recent contributions in the use of natural compounds and derivatives to reduce the risk of developing inflammatory and oxidant diseases such as cancer and others human disorders. Articles regarding the anticancer activity of natural compounds and derivatives are particularly encouraged.

Natural products are bioactive compounds synthesized by terrestrial and marine plants, microorganisms and animals. Traditionally, they have been used in the prevention and treatment of various human diseases in different cultures. In parallel, chemical derivatives of these natural compounds have been used in order to enhance their bioactivities. During the last ten years, most of them have been reported to have a variety of interesting and significant biological properties, such as analgesic, anti-allodynic, anti-diabetic, anti-oxidant, anti-parasitic, antimicrobial, anti-viral, anti-atherogenic, anti-inflammatory, anti-proliferative, anti-tumor, growth-stimulating activities, as well as cardio and neuro-protective activities. However, special attention has been focused on the study of their anti-tumor capacity, through the potential modulation of cancer initiation and growth, cellular differentiation, apoptosis and autophagy, angiogenesis, and metastatic dissemination. Moreover, a considerable number of studies reported the relation of the anticancer effect with their anti-inflammatory and antioxidant activities. Besides these capacities, the use of natural compounds and derivatives represent one of the most promising strategies to treat metabolic disorders (oxidative stress, diabetes, obesity, metabolic syndrome, and so on). The biological activity of natural extracts without a proper chemical characterization will not be considered.


  • New natural compounds and derivatives as anticancer agents
  • Use of natural compounds and derivatives as anti-inflammatory agents in human disorders
  • Natural products and derivatives in oxidative stress associated with human diseases
  • Molecular mechanism implicated of natural products and derivatives
  • Effects of natural products and derivatives on nutrition and diet on human diseases
  • Type of natural product and derivatives with potential bioactive, extraction and synthesis

Professors Eva E. Rufino-Palomares and José Antonio Lupiáñez Cara

Guest and Co-Guest Editors

Prof. José Antonio Lupiáñez
Prof. Eva E. Rufino-Palomares
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • anti-inflamation
  • cancer
  • chemical derivatives
  • chemoprevention
  • human disorders
  • molecular mechanism
  • natural products
  • oxidative stress

Published Papers

This special issue is now open for submission.
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