Special Issue "Multicomponent Reactions"
Deadline for manuscript submissions: 31 March 2019
Dr. Cimarelli Cristina
Multicomponent reactions share many features that make them very appealing to organic chemists. According to a commonly-accepted definition, “MCRs are reactions with three and more starting materials where the majority of the atoms of the starting material are incorporated in the product”. MCRs start mixing three or more reagents, continue in one-pot fashion through several reaction steps without human intervention to isolate and separate intermediates and converge on a final product, which, in almost all cases, contains all the atoms of the starting material, with little or no side products. They appear to be ideal for any form of synthesis, because of their high atom economy and bond-forming efficiency, low-cost separation and purification of products, and scarce waste formation. Futhermore they offer the possibility to produce molecular diversity in combinatorial synthesis, and, in many cases, may be adapted to automation. Furthermore, from a purely academic point of view, all multicomponent reactions involve a plethora of chemical reactions, offering the possibility to study many beautiful and interesting chemistry.
Many fields of organic chemistry have been taking advantage of multicomponent reactions; thus, selected papers are welcomed that open new perspectives in MCR chemistry with creative results, and in MCRs applications to the synthesis of various classes of organic compounds, not only in organic synthesis and drug discovery, but also in material science, agriculture, medical devices, imaging, or in other fields, such as solar energy, stem cell therapy or superconductivity.Dr. Cimarelli Cristina
Manuscript Submission Information
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- multicomponent reactions
- small molecules
- heterocycle synthesis
- green chemistry
- synthetic methodologies