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Special Issue "EGCG, Green Tea and Polyphenols"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 30 April 2019

Special Issue Editor

Guest Editor
Dr. Helieh S. Oz

University of Kentucky Medical Center, Lexington, KY, USA
Website | E-Mail
Interests: inflammatory and infectious diseases; nutrients; antioxidants; reactive oxygen radical; gastrointestinal inflammation; inflammatory bowel disease; microbial; parasitic and fungal infectious diseases; hepatic; pancreatic complication; models of infections and inflammation; nutraceutical and therapeutic discoveries

Special Issue Information

Dear Colleagues,

Green tea is extracted from shrub, Camellia sinensis, leaves and is consumed as one of the most common beverages around the world. Green tea and its main polyphenolic component, epigalloccatechin-3-gallate (EGCG), are known to have putative health effects, such as antioxidant, anti-inflammatory, antmicrobial, and anti-carcinogenic properties. In addition, EGCG and other polyphenols are known to modulate nuclear factor kappa B (NF-kB), IKK activity and to inhibit inflammatory markers (e.g., TNFα, IL-6) and bioenzymes (e.g., myeloperoxidase). Green tea and polyphenols are believed to support microbiome and gut health. In addition, tea compounds are used in cosmetics and implemented as natural food preservative.

This Special Issue aims to identify and review the latest bioactive compounds from tea and polyphenols to have beneficial effects in body. Authors are invited to submit relevant papers on novel activities of green tea, polyphenols including EGCG activities, and strategies to support or to depose beneficial effect on inflammatory, microbial, viral, and antioxidants measurements. Moreover, discoveries of the mechanism of actions by which tea and its polyphenols may support the microbiome and gut health to prevent inflammatory complications are of particular interest. Basic, pilot clinical and translational and retrospective trials, as well as review articles in this area are of interest.

Dr. Helieh S. Oz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • green tea
  • EGCG
  • polyphenols
  • mechanism of action

Published Papers (2 papers)

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Review

Open AccessReview Bioavailability of Tea Catechins and Its Improvement
Molecules 2018, 23(9), 2346; https://doi.org/10.3390/molecules23092346
Received: 3 August 2018 / Revised: 2 September 2018 / Accepted: 12 September 2018 / Published: 13 September 2018
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Abstract
Many in vitro studies have shown that tea catechins had vevarious health beneficial effects. However, inconsistent results between in vitro and in vivo studies or between laboratory tests and epidemical studies are observed. Low bioavailability of tea catechins was an important factor leading
[...] Read more.
Many in vitro studies have shown that tea catechins had vevarious health beneficial effects. However, inconsistent results between in vitro and in vivo studies or between laboratory tests and epidemical studies are observed. Low bioavailability of tea catechins was an important factor leading to these inconsistencies. Research advances in bioavailability studies involving absorption and metabolic biotransformation of tea catechins were reviewed in the present paper. Related techniques for improving their bioavailability such as nanostructure-based drug delivery system, molecular modification, and co-administration of catechins with other bioactives were also discussed. Full article
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
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Open AccessReview Suppressive Effects of EGCG on Cervical Cancer
Molecules 2018, 23(9), 2334; https://doi.org/10.3390/molecules23092334
Received: 9 August 2018 / Revised: 5 September 2018 / Accepted: 11 September 2018 / Published: 12 September 2018
PDF Full-text (880 KB) | HTML Full-text | XML Full-text
Abstract
Cervical cancer is the fourth most common gynecological cancer worldwide. Although prophylactic vaccination presents the most effective method for cervical cancer prevention, chemotherapy is still the primary invasive intervention. It is urgent to exploit low-toxic natural anticancer drugs on account of high cytotoxicity
[...] Read more.
Cervical cancer is the fourth most common gynecological cancer worldwide. Although prophylactic vaccination presents the most effective method for cervical cancer prevention, chemotherapy is still the primary invasive intervention. It is urgent to exploit low-toxic natural anticancer drugs on account of high cytotoxicity and side-effects of conventional agents. As a natural product, (-)-epigallocatechingallate (EGCG) has abilities in anti-proliferation, anti-metastasis and pro-apoptosis of cervical cancer cells. Moreover, EGCG also has pharmaceutical synergistic effects with conventional agents such as cisplatin (CDDP) and bleomycin (BLM). The underlying mechanisms of EGCG suppressive effects on cervical cancer are reviewed in this article. Further research directions and ambiguous results are also discussed. Full article
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
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