Special Issue "Applications of Metabolomics within Natural Products Chemistry"
Deadline for manuscript submissions: closed (30 July 2015)
Dr. Maria Halabalaki
1 CCB-Center for Chemistry and Biomedicine, Institute of Pharmacy/Pharmacognosy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria
2 Department of Pharmacognosy and Natural Product Chemistry, Faculty of Pharmacy, University of Athens, Panepistimioupoli-Zografou, 15771 Athens, Greece
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Interests: pharmacognosy; natural products chemistry; natural extracts characterization; dereplication; profiling; metabolomics
Natural products (NPs), low molecular weight compounds originated from nature, possess a predominant position among prevailing chemical entities. NPs are characterized by an unmet and untapped structural diversity and uniqueness; they are more complex in respect to decoration patterns and dispersal of functionalities while they cover an extended chemical space compared to other chemical agents. This particular nature is the positive consequence of the evolutionary process, which furnished NPs with competitive advantages, enabling them to interact with biological targets for the benefit of every living organism. The NPs privileged features have led to their broad utilization in medicine, pharmacology, and biology, where NPs still comprise a considerable driving force in drug discovery and inspiration for chemists. Additionally, NPs find several applications in many other fields and areas of research and development, such as in nutrition, agriculture, cosmetics, biotechnology, food chemistry, environmental chemistry, and botany, to name just a few.
Despite the proven track record of NPs, a declined interest of both the scientific community and private sector, such as big pharma, is evident. Some factors are strongly related to the endogenous problems of NP’s discovery process, which is traditionally laborious, costly, and time consuming, while the emergence of other concepts and approaches, such as combinatorial chemistry and high throughput screening (HTS) also guided toward this direction. Nevertheless, in the last few years, NP’s discovery and, generally, natural products chemistry and pharmacognosy are experiencing a breakthrough. The entire process is gradually becoming technology-driven. New techniques and approaches have been introduced and incorporated, especially in the areas of natural product’s isolation, identification, and analytics, altering traditional concepts and perceptions. One of these approaches, which was rapidly embraced by scientists, and generally the experts in the fiend of NPs, is metabolomics.
Metabolomics, taking advantage of technological advances and state-of-the-art analytical techniques, as well as the power of bioinformatics, comprise a new approach promising a holistic view of the metabolome of every biological system, aiming to a more comprehensive and multifaceted view in Systems Biology. Metabolomics, have been rapidly employed for the analysis of natural materials in a more holistic way, finding multiple applications and uses. According to the scope of the study, metabolic fingerprinting and metabolic profiling are applied in a targeted or non-targeted manner seeking to respond to a, usually, given biological or chemical question. Such approaches or NPs metabolomics, have been incorporated for chemotaxonomic studies, quality, safety and toxicity assessment, quality control, as well as for the exploration of physiological and biochemical effects in different environmental and stress conditions. Additionally, metabolomics have been employed for the investigation of the physiological development of different organisms and drug discovery. It is, indeed, worth mention that the number of metabolomics and metabolomics-related studies is gradually elevated in the area of NPs and new applications constantly appear. The integration and harmonization of metabolomics with traditional and contemporary methods and approaches could effectively facilitate the discovery and chemistry of NPs, which is expected to be seen.
Dr. Maria Halabalaki
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- NPs metabolomics and
- plants, marine organisms and microorganisms
- study design and workflows
- sample preparation protocols and related issues
- targeted and non-targeted approaches
- data processing and data interpretation
- identification of biomarkers and databases
- chemotaxonomy, abiotic stress and fluxomics
- quality assurance and quality control
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of the Paper: Article
Title: Herbal infusions or decoctions? An NMR based metabolomics approach on Greek species
Authors: Charalambos Fotakis 1, Diamantina Tsigrimani 1,2, Thalia Tsaka 1,2,
Irini Strati 3, Constantinos Makris 1,2, Dimitra Tagkouli 1,2, Charalambos Proestos 2, Vassilia J. Sinanoglou 3,*, Panagiotis Zoumpoulakis 1,*
Affiliations: 1 Institute of Biology, Medicinal Chemistry & Biotechnology, National Hellenic Research Foundation, 48, Vas. Constantinou Ave., 11635, Athens, Greece.
2 Department of Chemistry, National and Kapodistrian University of Athens, Athens, 15771, Greece
3 Department of Food Technology, Technological Educational Institution of Athens, Ag. Spyridonos Street, Aigaleo GR-12210, Athens, Greece
Abstract: This study implements NMR metabolomics and Spectrophotometry (DPPH, ABTS and Folin Ciocalteu assays) in order to put under the scope infusions and decoctions of 9 Greek herbal species, namely, Origanum majorana, Hypericum perforatum, Thymus capitatus, Mentha spicata, Lippia citriodora, Matricaria chamomilla, Hippophae hergo, Menta pulegium, Origanum vulgare. The global and phenolic profiles assessed by NMR were evaluated and correlations were attempted with the spectrophotometric results. The primary objective was to determine in either preparations, categories of metabolites that contribute to their nutritional characteristics emphasizing in their antioxidant profile. Secondly, implementation of multivariate statistical analysis of experimental data, highlighted differences between herbal species, as well as between the infusions and decoctions in order to propose preparations which yield the highest nutritional benefits.
Type of the Paper: Article
Title: Multicomponent analysis of the differential induction of secondary metabolite profiles in fungi
Authors: V. González-Menéndez, JR Tormo and O. Genilloud
Affiliations: Fundación MEDINA
Abstract: Small molecule Histone Deacetylase (HDAC) and DNA methyltransferase (DNMT) inhibitors are being used to perturb the production of fungal metabolites, leading to the induction of the expression of silent biosynthetic pathways. Several reports have described the variable effects observed in natural product profiles in fungi treated with HDAC and DNMT inhibitors, with enhanced chemical diversity or new molecules previously unknown to be produced by the organism. Fungal endophytes are known to produce a wide variety of secondary metabolites (SMs) involved in their adaptation and survival within higher plants. The plant-microbe interaction may influence the expression of some biosynthetic pathways, otherwise cryptic in these fungi when grown in vitro. The aim of the study was to identify the effect of several HDAC and DNMT inhibitors on the metabolic profile of selected fungal endophytes and the chemical characterization of the new SMs produced.