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Molecules 2016, 21(2), 234; doi:10.3390/molecules21020234

Multicomponent Analysis of the Differential Induction of Secondary Metabolite Profiles in Fungal Endophytes

Fundación MEDINA, Parque Tecnológico Ciencias de la Salud. Avda. del Conocimiento 34, 18016 Granada, Spain
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Academic Editor: Maria Halabalaki
Received: 10 November 2015 / Revised: 10 February 2016 / Accepted: 13 February 2016 / Published: 18 February 2016
(This article belongs to the Special Issue Applications of Metabolomics within Natural Products Chemistry)
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Abstract

Small molecule histone deacetylase (HDAC) and DNA methyltransferase (DNMT) inhibitors are commonly used to perturb the production of fungal metabolites leading to the induction of the expression of silent biosynthetic pathways. Several reports have described the variable effects observed in natural product profiles in fungi treated with HDAC and DNMT inhibitors, such as enhanced chemical diversity and/or the induction of new molecules previously unknown to be produced by the strain. Fungal endophytes are known to produce a wide variety of secondary metabolites (SMs) involved in their adaptation and survival within higher plants. The plant-microbe interaction may influence the expression of some biosynthetic pathways, otherwise cryptic in these fungi when grown in vitro. The aim of this study was to setup a systematic approach to evaluate and identify the possible effects of HDAC and DNMT inhibitors on the metabolic profiles of wild type fungal endophytes, including the chemical identification and characterization of the most significant SMs induced by these epigenetic modifiers. View Full-Text
Keywords: fungal endophytes; epigenetic modifiers; HDAC; DNMT; volcano plots; secondary metabolites; metabolomics fungal endophytes; epigenetic modifiers; HDAC; DNMT; volcano plots; secondary metabolites; metabolomics
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González-Menéndez, V.; Pérez-Bonilla, M.; Pérez-Victoria, I.; Martín, J.; Muñoz, F.; Reyes, F.; Tormo, J.R.; Genilloud, O. Multicomponent Analysis of the Differential Induction of Secondary Metabolite Profiles in Fungal Endophytes. Molecules 2016, 21, 234.

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