Special Issue "Design and Study of Kinase Inhibitors"

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A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: closed (31 July 2014)

Special Issue Editor

Guest Editor
Prof. Dr. Philippe Belmont
School of Pharmacy, University Paris Descartes, UMR CNRS 8638, case 24. 4, avenue de l’Observatoire, 75006 Paris, France
E-Mail: philippe.belmont@parisdescartes.fr
Interests: heterocyclic synthesis; nitrogen-containing heterocycles; methodologies using organic or organometallic reagents; organometallic catalysis; cyclo-isomerization reactions; cyclo-functionalization reactions; benzannulation; aminobenzannulation; pi-acid metal catalysis; silver chemistry; gold chemistry; cobalt chemistry; Pauson-Khand reaction; bioactive compounds; alkaloids; kinases inhibition

Special Issue Information

Dear Colleagues,

In recent years, the design and study of kinase inhibitors has become an important field of interest. The arrival of imatinib (Glivec®, Novartis) on the market in the early 2000s opened the way for targeted therapies with heterocyclic molecules. Meanwhile, heterocyclic chemistry has received increasing attention in organic and organometallic methodologies. The green chemistry development brought the community access to heterocycles through new, efficient, and eco-friendly methodologies, including novel chemical conditions (e.g., metal-catalyzed or metal-free) and the use of new reaction conditions (e.g., microwave, solvent-free). Thanks to co-crystallization data (when possible) and molecular modeling studies (including docking), the link between heterocycle synthesis and their kinases’ inhibitory properties (i.e., the structure-activity relationships) has been further elucidated and is nowadays increasingly predictable.

Therefore, the Special Issue’s scope, which concerns the “design and study of kinase inhibitors”, is broad. Possible topics may concern original access to various heterocyclic cores (through creative methodological developments) and close collaborations with either biologists/crystallographers or molecular modeling partners that empower inhibitor development and the hit to lead maturation.

Prof. Dr. Philippe Belmont
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).


Keywords

  • heterocycles
  • kinase inhibition
  • signal transduction study
  • organic synthesis
  • organometallic catalysis
  • molecular modeling

Published Papers (12 papers)

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p. 16937-16949
by , , ,  and
Molecules 2014, 19(10), 16937-16949; doi:10.3390/molecules191016937
Received: 8 September 2014; in revised form: 11 October 2014 / Accepted: 14 October 2014 / Published: 22 October 2014
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(This article belongs to the Special Issue Design and Study of Kinase Inhibitors)
p. 16223-16239
by , , , ,  and
Molecules 2014, 19(10), 16223-16239; doi:10.3390/molecules191016223
Received: 31 July 2014; in revised form: 24 September 2014 / Accepted: 26 September 2014 / Published: 10 October 2014
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(This article belongs to the Special Issue Design and Study of Kinase Inhibitors)
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p. 15546-15571
by , , , , , , ,  and
Molecules 2014, 19(10), 15546-15571; doi:10.3390/molecules191015546
Received: 29 July 2014; in revised form: 19 September 2014 / Accepted: 22 September 2014 / Published: 29 September 2014
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(This article belongs to the Special Issue Design and Study of Kinase Inhibitors)
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p. 15391-15407
by , , , , ,  and
Molecules 2014, 19(10), 15391-15407; doi:10.3390/molecules191015391
Received: 7 August 2014; in revised form: 12 September 2014 / Accepted: 17 September 2014 / Published: 26 September 2014
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(This article belongs to the Special Issue Design and Study of Kinase Inhibitors)
p. 15411-15439
by , , , , , , ,  and
Molecules 2014, 19(10), 15411-15439; doi:10.3390/molecules191015411
Received: 7 August 2014; in revised form: 15 September 2014 / Accepted: 16 September 2014 / Published: 26 September 2014
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(This article belongs to the Special Issue Design and Study of Kinase Inhibitors)
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p. 15196-15212
by ,  and
Molecules 2014, 19(9), 15196-15212; doi:10.3390/molecules190915196
Received: 6 August 2014; in revised form: 8 September 2014 / Accepted: 10 September 2014 / Published: 23 September 2014
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(This article belongs to the Special Issue Design and Study of Kinase Inhibitors)
p. 15237-15257
by , , , , ,  and
Molecules 2014, 19(9), 15237-15257; doi:10.3390/molecules190915237
Received: 31 July 2014; in revised form: 8 September 2014 / Accepted: 11 September 2014 / Published: 23 September 2014
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(This article belongs to the Special Issue Design and Study of Kinase Inhibitors)
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p. 14304-14315
by ,  and
Molecules 2014, 19(9), 14304-14315; doi:10.3390/molecules190914304
Received: 22 July 2014; in revised form: 3 September 2014 / Accepted: 9 September 2014 / Published: 11 September 2014
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(This article belongs to the Special Issue Design and Study of Kinase Inhibitors)
p. 14366-14382
by  and
Molecules 2014, 19(9), 14366-14382; doi:10.3390/molecules190914366
Received: 25 July 2014; in revised form: 26 August 2014 / Accepted: 28 August 2014 / Published: 11 September 2014
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(This article belongs to the Special Issue Design and Study of Kinase Inhibitors)
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p. 13848-13877
by , , , ,  and
Molecules 2014, 19(9), 13848-13877; doi:10.3390/molecules190913848
Received: 31 July 2014; in revised form: 25 August 2014 / Accepted: 29 August 2014 / Published: 4 September 2014
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(This article belongs to the Special Issue Design and Study of Kinase Inhibitors)
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p. 13200-13211
by , , , ,  and
Molecules 2014, 19(9), 13200-13211; doi:10.3390/molecules190913200
Received: 15 July 2014; in revised form: 18 August 2014 / Accepted: 22 August 2014 / Published: 27 August 2014
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(This article belongs to the Special Issue Design and Study of Kinase Inhibitors)
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p. 8890-8903
by  and
Molecules 2014, 19(7), 8890-8903; doi:10.3390/molecules19078890
Received: 5 May 2014; in revised form: 5 June 2014 / Accepted: 12 June 2014 / Published: 26 June 2014
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Last update: 18 July 2014

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