Special Issue "Design and Study of Kinase Inhibitors"
Deadline for manuscript submissions: closed (31 July 2014)
Prof. Dr. Philippe Belmont
School of Pharmacy, University Paris Descartes, UMR CNRS 8638, case 24. 4, avenue de l’Observatoire, 75006 Paris, France
Interests: heterocyclic synthesis; nitrogen-containing heterocycles; methodologies using organic or organometallic reagents; organometallic catalysis; cyclo-isomerization reactions; cyclo-functionalization reactions; benzannulation; aminobenzannulation; pi-acid metal catalysis; silver chemistry; gold chemistry; cobalt chemistry; Pauson-Khand reaction; bioactive compounds; alkaloids; kinases inhibition
In recent years, the design and study of kinase inhibitors has become an important field of interest. The arrival of imatinib (Glivec®, Novartis) on the market in the early 2000s opened the way for targeted therapies with heterocyclic molecules. Meanwhile, heterocyclic chemistry has received increasing attention in organic and organometallic methodologies. The green chemistry development brought the community access to heterocycles through new, efficient, and eco-friendly methodologies, including novel chemical conditions (e.g., metal-catalyzed or metal-free) and the use of new reaction conditions (e.g., microwave, solvent-free). Thanks to co-crystallization data (when possible) and molecular modeling studies (including docking), the link between heterocycle synthesis and their kinases’ inhibitory properties (i.e., the structure-activity relationships) has been further elucidated and is nowadays increasingly predictable.Therefore, the Special Issue’s scope, which concerns the “design and study of kinase inhibitors”, is broad. Possible topics may concern original access to various heterocyclic cores (through creative methodological developments) and close collaborations with either biologists/crystallographers or molecular modeling partners that empower inhibitor development and the hit to lead maturation.
Prof. Dr. Philippe Belmont
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- kinase inhibition
- signal transduction study
- organic synthesis
- organometallic catalysis
- molecular modeling
Article: Cytotoxic Activity of 3,6-Dihydroxyflavone in Human Cervical Cancer Cells and Its Therapeutic Effect on c-Jun N-Terminal Kinase Inhibition
Molecules 2014, 19(9), 13200-13211; doi:10.3390/molecules190913200
Received: 15 July 2014; in revised form: 18 August 2014 / Accepted: 22 August 2014 / Published: 27 August 2014| PDF Full-text (1330 KB)
Communication: Using MUSIC and CC(CO)NH for Backbone Assignment of Two Medium-Sized Proteins Not Fully Accessible to Standard 3D NMR
Molecules 2014, 19(7), 8890-8903; doi:10.3390/molecules19078890
Received: 5 May 2014; in revised form: 5 June 2014 / Accepted: 12 June 2014 / Published: 26 June 2014| PDF Full-text (306 KB) | HTML Full-text | XML Full-text
Last update: 18 July 2014