Special Issue "Heck Coupling"
Deadline for manuscript submissions: closed (31 January 2010)
Prof. Dr. Cinzia Chiappe
Dipartimento di Chimica e Chimica Industriale, University of Pisa, c/o via Bonanno 33, 56126 Pisa, Italy
Phone: +39 050 2219669
Fax: +39 050 2219660
Interests: Pd promoted cross couplings, regioselectivity of inter- and intramolecular reactions, catalyst developments, neoteric solvents, Heck reactions in solid phases, continuous processes, waste-minimized processes
All papers should be submitted to firstname.lastname@example.org with copy to the guest editor. To be published continuously until the deadline and papers will be listed together at the special websites.
Submitted papers should not have been previously published nor be currently under consideration for publication elsewhere. All papers are refereed through a peer review process. A guide for authors, sample copies and other relevant information for submitting papers are available on the Instructions for Authors page. Molecules is an international peer-reviewed monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a paper. Article Processing Charges (APC) are 800 CHF per paper and additional English correction fees (250 CHF) will be added in certain cases (1050CHF per paper for those papers that require extensive additional formatting and/or English corrections) for paper submitted before 31 December 2009. Starting 1 January 2010, Article Processing Charges are of 1400 CHF per accepted article for Molecules.
- Pd promoted cross couplings
- Regioselectivity of inter- and intramolecular reactions
- Catalyst developments
- Neoteric solvents
- Heck reactions in solid phases
- Continuous processes
- Waste-minimized processes
Molecules 2009, 14(8), 3019-3029; doi:10.3390/molecules14083019
Received: 20 July 2009; in revised form: 30 July 2009 / Accepted: 12 August 2009 / Published: 13 August 2009| Download PDF Full-text (293 KB)
Article: Palladium(II)/Cationic 2,2’-Bipyridyl System as a Highly Efficient and Reusable Catalyst for the Mizoroki-Heck Reaction in Water
Molecules 2010, 15(1), 315-330; doi:10.3390/molecules15010315
Received: 18 December 2009; in revised form: 8 January 2009 / Accepted: 12 January 2010 / Published: 12 January 2010| Download PDF Full-text (178 KB)
Article: Palladium-Catalyzed Heck Coupling Reaction of Aryl Bromides in Aqueous Media Using Tetrahydropyrimidinium Salts as Carbene Ligands
Molecules 2010, 15(2), 649-659; doi:10.3390/molecules15020649
Received: 16 December 2009; in revised form: 1 January 2010 / Accepted: 12 January 2010 / Published: 28 January 2010| Download PDF Full-text (214 KB)
Molecules 2010, 15(3), 1302-1308; doi:10.3390/molecules15031303
Received: 30 January 2010; in revised form: 10 February 2010 / Accepted: 2 March 2010 / Published: 4 March 2010| Download PDF Full-text (259 KB)
Molecules 2010, 15(3), 1487-1500; doi:10.3390/molecules15031487
Received: 15 January 2010; in revised form: 2 February 2010 / Accepted: 8 March 2010 / Published: 9 March 2010| Download PDF Full-text (255 KB)
Article: Selective Heck Arylation of Cyclohexene with Homogeneous and Heterogeneous Palladium Catalysts
Molecules 2010, 15(4), 2166-2177; doi:10.3390/molecules15042166
Received: 27 January 2010; in revised form: 10 March 2010 / Accepted: 23 March 2010 / Published: 25 March 2010| Download PDF Full-text (415 KB)
Molecules 2010, 15(4), 2211-2245; doi:10.3390/molecules15042211
Received: 3 March 2010; in revised form: 22 March 2010 / Accepted: 26 March 2010 / Published: 30 March 2010| Download PDF Full-text (1077 KB)
Review: The Heck Reaction Applied to 1,3- and 1,2-Unsaturated Derivatives, a Way towards Molecular Complexity
Molecules 2010, 15(4), 2667-2685; doi:10.3390/molecules15042667
Received: 1 February 2010; in revised form: 26 March 2010 / Accepted: 1 April 2010 / Published: 13 April 2010| Download PDF Full-text (378 KB)
Molecules 2010, 15(5), 3402-3410; doi:10.3390/molecules15053402
Received: 25 February 2010; in revised form: 30 April 2010 / Accepted: 6 May 2010 / Published: 10 May 2010| Download PDF Full-text (227 KB)
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Review
Title: The Heck Coupling in Peptide Science
Author: Gerardo Byk
Affiliation: Laboratory of Nano-Biotechnology Dept. of Chemistry Bar-Ilan University 52900-Ramat Gan ISRAEL; Email: email@example.com
Abstract: The use of Heck coupling has been extensively applied to small molecules synthesis but unlike ring-closure metathesis (Grubbs) reaction only at a limited extent to peptide chemistry for peptide decoration and some peptide cyclization. We acknowledge 62 citations in scifinder using the keywords "Heck reaction" and "peptide" , while when using "Metathesis" and "peptide" we find at least 576 results. The main reason that hampered the use of this reaction in peptide science is the strong conditions needed in many cases for obtaining the products in contrast to Grubbs metathesis. This reaction is usually carried out over 120 0C for long period of times even several days especially when difficult cyclization is needed. The use of microwave energy facilitated dramatically the use of this reaction in peptide science. We will report a comprehensive review going from the early use of Heck coupling in peptide science until the late applications using microwave assisted Heck coupling in peptides and potential future applications both in solution and solid phase. The aim of the review will be to motivate chemists in peptide science to improve the use of this reaction for peptidomimetic and other modifications needed in peptide science.
Last update: 14 April 2010