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Molecules 2010, 15(4), 2667-2685; doi:10.3390/molecules15042667

The Heck Reaction Applied to 1,3- and 1,2-Unsaturated Derivatives, a Way towards Molecular Complexity

Dipartimento di Chimica Generale e Chimica Organica, Università di Torino, Via Pietro Giuria, 7, I 10125, Torino, Italy
Author to whom correspondence should be addressed.
Received: 1 February 2010 / Revised: 26 March 2010 / Accepted: 1 April 2010 / Published: 13 April 2010
(This article belongs to the Special Issue Heck Coupling)
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This review is an overview of the last ten years’ use of the Mizoroki–Heck coupling applied to 1,2- and 1,3-dienes. Since both these systems form π-allyl palladium intermediates in Pd(0) coupling, they show particular chemical behavior. Many examples of 1,2-dienes Heck reactions are presented. 1,2-Dienes are important substrates because of their high reactivity that makes them useful building blocks for the synthesis of biologically relevant structures.
Keywords: Mizoroki–Heck reaction; palladium; 1,2-dienes; 1,3-dienes Mizoroki–Heck reaction; palladium; 1,2-dienes; 1,3-dienes
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Deagostino, A.; Prandi, C.; Tabasso, S.; Venturello, P. The Heck Reaction Applied to 1,3- and 1,2-Unsaturated Derivatives, a Way towards Molecular Complexity. Molecules 2010, 15, 2667-2685.

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