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Special Issue "Gene Delivery"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 30 May 2018

Special Issue Editor

Guest Editor
Prof. Dr. T.J. Thomas

Department of Medicine, Rutgers Robert Wood Johnson Medical School, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA
Website | E-Mail
Interests: Breast Cancer; Polyamines; Nanotechnology; Gene Delivery; Oligonucleotides; Estrogen Receptor; Antiestrogens

Special Issue Information

Dear Colleagues,

Gene therapy promises effective treatment for a variety of diseases, including cystic fibrosis, cancer and Alzheimer’s disease. Safe and efficient gene delivery vehicles are essential to advance gene therapy to clinical arena. Several investigators are involved in developing new carrier materials and fabricating functional materials aimed at improving gene therapy protocols. This Special Issue of Molecules will publish a collection of articles with a focus on “Gene Delivery”, including DNA and RNA delivery using viral and non-viral vectors. Original articles and reviews will be published in this Special Issue.

Prof. Dr. T.J. Thomas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Aptamer delivery
  • Cationic polymers and gene delivery
  • Co-delivery of drugs and genes
  • Dendrimers and gene delivery
  • DNA-carrier interactions
  • DNA/RNA condensation
  • Gene delivery
  • miRNA delivery
  • Nanocarriers as gene delivery vehicles
  • Non-viral gene delivery
  • siRNA delivery
  • Stimuli sensitive delivery vehicles

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Advances in mitochondria-targeted gene delivery
Author: Kwang-il Lim
Abstract: Mitochondria are the energy-producing essential organelles of cells. Mitochondrial dysfunctions indirectly link to or directly lead to various syndromes and diseases including Kearns-Sayre syndrome (KSS), Leigh syndrome (LS), Leber hereditary optic neuropathy (LHON) and Alpers disease. Mitochondrial dysfunctions mostly result from mutations of mitochondrial genomes and nuclear genes that encode mitochondrial components. However, complete correction of the mutated genetic parts in cells relevant to mitochondrial structures and functions is technically challenging. Instead, there have been diverse attempts to provide fully functional mitochondrial components with cells via intracellular delivery of corrected genetic units. In this review, we will especially focus on discussing recent novel physical, chemical and biological approaches to transfer genetic cargos into mitochondria and the following physiological changes.

Title: A tool or a toy? Human Artificial Chromosomes for gene delivery and kinetochore studies".
Author: Dr. Natalie Kouprina

Title: Gene delivery into inner ear and treatment
Author: Sho Kanzaki
Abstract: The most of sensorineural hearing loss damage to the cochlea including lost hair cells (HCs) and spiral ganglion neurons (SGNs).
Mammalian cochlear HC loss cannot regenerate. The protection from SGN from degeneration has also implications for cochlear implant to patients with severe deafness.
We review the gene delivery for treatment in animal experiments.
Transgene expression of the neurotrophic factor can maintain SGN and describe potential new therapeutic interventions.
We also summarized viral vectors and introduced the gene delivery for regeneration and protection of cochlear HCs.

Title: Gene delivery into inner ear - its clinical implication
Author: Sho Kanzaki
Abstract: Gene delivery introduction into inner ear expected the inner ear regeneration and protection of neural degenerationfor patients with sensorineural hearing loss. inner ear is surrounded by bony capsule, however, two membranes are Gene delivery with Atoh1 can regenerate sensory cells or hair cells in animals. Delivery of neurotrophic factor can also protect auditory neuron from degeneration and could improve hearing results in cochlear implant patients.

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