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Special Issue "Recent Advances in Chiroptical Spectroscopy"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: 31 May 2018

Special Issue Editor

Guest Editor
Prof. Dr. Reiko Kuroda

Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki,Noda-shi, Chiba 278-8510 Japan
Website | E-Mail
Interests: chiroptical spectroscopy especially in the condensed phase; chiral recognition, discrimination and enhancement in the solid state; chirality determination mechanism of snail Lymnaea stagnalis by a single gene during the embryogenesis

Special Issue Information

Dear Colleagues,

Chirality is expressed throughout nature, whether microscopic or macroscopic, and animate or inanimate. Examples include molecules, crystals and complex living organisms. From the molecular standpoint, life is totally homochiral; that is, all living organisms on Earth use molecules of a unique invariant handedness: only D- (deoxy) ribose in nucleic acids and only L-amino acids in proteins. Thus, chirality is a key issue in understanding the origin of life on Earth, as well as in agricultural, pharmaceutical and food industries as their biological effects often depend on the chirality of compounds.

The present Special Issue, “Recent Advances in Chiroptical Spectroscopy”, aims to provide comprehensive coverage of the most important and up-to-date methods dealing with polarized light, including their basic principles, instrumentation, and theoretical simulation for application to organic molecules, inorganic molecules, and biomolecules.

Prof. Dr. Reiko Kuroda
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • VCD/ECD/CPL/CD/ROA
  • Instrumentation (condensed phases, fast measurements etc.)
  • Theoretical approaches
  • Biomolecules (proteins/peptides/lipids/nucleic acids/sugars etc.)
  • Organic compounds/liquid crystals/supramolecules
  • Inorganic compounds (transition metal complexes, lanthanides etc.)

Published Papers (1 paper)

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Research

Open AccessArticle Chiral and Molecular Recognition through Protonation between Aromatic Amino Acids and Tripeptides Probed by Collision-Activated Dissociation in the Gas Phase
Molecules 2018, 23(1), 162; doi:10.3390/molecules23010162
Received: 6 December 2017 / Revised: 6 January 2018 / Accepted: 11 January 2018 / Published: 13 January 2018
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Abstract
Chiral and molecular recognition through protonation was investigated through the collision-activated dissociation (CAD) of protonated noncovalent complexes of aromatic amino acid enantiomers with l-alanine- and l-serine-containing tripeptides using a linear ion trap mass spectrometer. In the case of l-alanine-tripeptide (AAA),
[...] Read more.
Chiral and molecular recognition through protonation was investigated through the collision-activated dissociation (CAD) of protonated noncovalent complexes of aromatic amino acid enantiomers with l-alanine- and l-serine-containing tripeptides using a linear ion trap mass spectrometer. In the case of l-alanine-tripeptide (AAA), NH3 loss was observed in the CAD of heterochiral H+(d-Trp)AAA, while H2O loss was the main dissociation pathways for l-Trp, d-Phe, and l-Phe. The protonation site of heterochiral H+(d-Trp)AAA was the amino group of d-Trp, and the NH3 loss occurred from H+(d-Trp). The H2O loss indicated that the proton was attached to the l-alanine tripeptide in the noncovalent complexes. With the substitution of a central residue of l-alanine tripeptide to l-Ser, ASA recognized l-Phe by protonation to the amino group of l-Phe in homochiral H+(l-Phe)ASA. For the protonated noncovalent complexes of His enantiomers with tripeptides (AAA, SAA, ASA, and AAS), protonated His was observed in the spectra, except for those of heterochiral H+(d-His)SAA and H+(d-His)AAS, indicating that d-His did not accept protons from the SAA and AAS in the noncovalent complexes. The amino-acid sequences of the tripeptides required for the recognition of aromatic amino acids were determined by analyses of the CAD spectra. Full article
(This article belongs to the Special Issue Recent Advances in Chiroptical Spectroscopy)
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