Special Issue "Cell and Tissue Metabolomics"


A special issue of Metabolites (ISSN 2218-1989).

Deadline for manuscript submissions: closed (30 June 2014)

Special Issue Editor

Guest Editor
Dr. Justin J.J. van der Hooft
Plant Products and Human Nutrition group, North Lab, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK
Website: http://www.linkedin.com/pub/justin-van-der-hooft/35/a93/9aa
Phone: +441413308611
Interests: mass spectrometry; mass spectrometry fragmentation; nuclear magnetic resonance spectroscopy; metabolite identification; structural elucidation; metabolite annotation; automated metabolite annotation; polyphenols; bioavailability; metabolomics; urine

Special Issue Information

Dear Colleagues,

The last two decades we have witnessed an exciting development of metabolomics techniques and approaches. Without disregarding the other analytical tools, the two main analytical pillars are currently mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR). The total extracts of numerous plants, yeast, and human bio fluids were comprehensively characterised. With the equipment getting increasingly sensitive, we now see the first examples of cell and tissue metabolomes being, at least partially, resolved, with cancer cells and tissues being in the centre of attention.

Again the main challenges to be expected are: i) can we fully elucidate all detected metabolites, and ii) can we develop protocols for robust extraction and detection of the small metabolites? There are several interesting questions to be addressed: a) how can we learn from previous metabolomics studies, b) how can we organize the tremendous amount of data and metadata on metabolites in the most efficient way, and c) how can software tools help us solving the metabolomics challenges?

Herewith I invite you to contribute to this special issue of Metabolites: original research, a reviewing of the initial attempts, and ideas on how to tackle the cell and tissue metabolomics challenges in the nearby future are all welcome, from both the plant and human metabolomics field.

Dr. Justin J.J. van der Hooft

Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 800 CHF (Swiss Francs).


  • metabolomics
  • cell metabolomics
  • tissue metabolomics
  • metabolite annotation
  • metabolite identification
  • mass spectrometry
  • NMR
  • GC-MS
  • LC-MS
  • spectral databases
  • compound databases
  • sample preparation techniques
  • metabolic networks

Published Papers (4 papers)

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Displaying article 1-4
p. 831-878
by , , ,  and
Metabolites 2014, 4(3), 831-878; doi:10.3390/metabo4030831
Received: 29 June 2014 / Revised: 2 September 2014 / Accepted: 18 September 2014 / Published: 25 September 2014
Show/Hide Abstract | Cited by 3 | PDF Full-text (709 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Cell and Tissue Metabolomics)
p. 421-432
by , , , ,  and
Metabolites 2014, 4(2), 421-432; doi:10.3390/metabo4020421
Received: 1 April 2014 / Revised: 20 May 2014 / Accepted: 22 May 2014 / Published: 30 May 2014
Show/Hide Abstract | Cited by 3 | PDF Full-text (1061 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Cell and Tissue Metabolomics)
p. 142-165
by ,  and
Metabolites 2014, 4(2), 142-165; doi:10.3390/metabo4020142
Received: 13 January 2014 / Revised: 18 March 2014 / Accepted: 20 March 2014 / Published: 31 March 2014
Show/Hide Abstract | Cited by 6 | PDF Full-text (579 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Cell and Tissue Metabolomics)
p. 98-114
by , , , , , ,  and
Metabolites 2014, 4(1), 98-114; doi:10.3390/metabo4010098
Received: 4 December 2013 / Revised: 8 January 2014 / Accepted: 20 January 2014 / Published: 27 January 2014
Show/Hide Abstract | Cited by 8 | PDF Full-text (978 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Cell and Tissue Metabolomics)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Unraveling Signaling and Biochemical Pathways Induced by Mitochondrial Dysfunctions by Using Metabolomic Approaches
S. Demine1, R. Nagabushana1, M. Raes1, P. Renard1 and T. Arnould1
1 Unité de Recherche en Biologie Cellulaire (URBC), NAmur Research Institute for Life Sciences (NARILIS), University of Namur (UNamur), Belgium
Mitochondrial dysfunction(s) (MDs) can be defined as an alteration of the mitochondria including mitochondrial uncoupling, mitochondrial depolarization, inhibition of mitochondrial respiratory chain, mitochondrial network fragmentation, mitochondrial or nuclear DNA mutations and mitochondrial accumulation of protein aggregates. These MDs are known to be induced by several pathological states/diseases including cancer, obesity, muscular and neurological troubles. On the other hand, these conditions can also induce several mitochondrial dysfunctions by themselves. Induction of MDs can alter secretion of several metabolites (i.e. pro-inflammatory cytokines), reactive oxygen species (ROS) production and modify several cell signaling pathways (cytosolic calcium concentration, AMPK, PI3K, Akt, PKC, MEK pathways) in order to attempt to resolve the mitochondrial dysfunction or to ultimately trigger cell death. Along with ROS, many metabolites, such as fatty acids and derived compounds, could be also secreted into the blood stream by cells suffering from mitochondrial dysfunctions. In this review, we propose to summarize how some metabolites are able to induce or can be modified by a mitochondrial dysfunction, along with the signaling pathways and transcription factors involved in this process, with a strong emphasis on MU. For this purpose, we will summarize how it is possible to identify consequences or causes of a mitochondrial dysfunction by using complementary transcriptomics, proteomics (2D gels, liquid chromatography, gas chromatography) and metabolomics (liquid chromatography associated with mass spectrometry analysis, NMR spectrometry, PET scan, nanofluidic analysis of isolated mitochondria) approaches.

Last update: 6 February 2014

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