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Metabolites 2014, 4(2), 421-432; doi:10.3390/metabo4020421
Article

Metabolome Consistency: Additional Parazoanthines from the Mediterranean Zoanthid Parazoanthus Axinellae

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Received: 1 April 2014; in revised form: 20 May 2014 / Accepted: 22 May 2014 / Published: 30 May 2014
(This article belongs to the Special Issue Cell and Tissue Metabolomics)
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Abstract: Ultra-high pressure liquid chromatography coupled to high resolution mass spectrometry (UHPLC-MS/MS) analysis of the organic extract obtained from the Mediterranean zoanthid Parazoanthus axinellae yielded to the identification of five new parazoanthines F-J. The structures were fully determined by comparison of fragmentation patterns with those of previously isolated parazoathines and MS/MS spectra simulation of in silico predicted compounds according to the metabolome consistency. The absolute configuration of the new compounds has been assigned using on-line electronic circular dichroism (UHPLC-ECD). We thus demonstrated the potential of highly sensitive hyphenated techniques to characterize the structures of a whole family of natural products within the metabolome of a marine species. Minor compounds can be characterized using these techniques thus avoiding long isolation processes that may alter the structure of the natural products. These results are also of interest to identify putative bioactive compounds present at low concentration in a complex mixture.
Keywords: LC-MS/MS; parazoanthine; zoanthid; Parazoanthus axinellae; ECD LC-MS/MS; parazoanthine; zoanthid; Parazoanthus axinellae; ECD
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Audoin, C.; Cocandeau, V.; Thomas, O.P.; Bruschini, A.; Holderith, S.; Genta-Jouve, G. Metabolome Consistency: Additional Parazoanthines from the Mediterranean Zoanthid Parazoanthus Axinellae. Metabolites 2014, 4, 421-432.

AMA Style

Audoin C, Cocandeau V, Thomas OP, Bruschini A, Holderith S, Genta-Jouve G. Metabolome Consistency: Additional Parazoanthines from the Mediterranean Zoanthid Parazoanthus Axinellae. Metabolites. 2014; 4(2):421-432.

Chicago/Turabian Style

Audoin, Coralie; Cocandeau, Vincent; Thomas, Olivier P.; Bruschini, Adrien; Holderith, Serge; Genta-Jouve, Grégory. 2014. "Metabolome Consistency: Additional Parazoanthines from the Mediterranean Zoanthid Parazoanthus Axinellae." Metabolites 4, no. 2: 421-432.



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