Special Issue "Marine Compounds and Inflammation"
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (30 April 2013)
Prof. Dr. Agostino Casapullo
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, via Ponte don Melillo, 84084 Fisciano, Italy
Phone: +39 089 969243
Fax: +39 089 969602
Interests: marine natural products; structure elucidation; chemical proteomics; target discovery; bioorganic chemistry
Oceans cover about 70% of the earth’s surface and marine organisms comprise approximately a half of the total biodiversity. Marine natural products possess a unique chemical diversity and have evolved for optimal interactions with biological macromolecules, constituting an enormous library of novel compounds with wide biological properties useful in the drug discovery process.
The search for new drugs is currently moving toward a rationalization in which chemistry and pharmacology are joined into a targeted approach to drug discovery, focused on specific diseases and molecular targets. In this context, inflammation is increasingly considered a crucial biological pathway, due to its involvement in a large number of diseases such as allergies, asthma, rheumatoid arthritis, inflammatory bowel diseases, atherosclerosis, and in particular in the initiation and progression cancer, strictly implicated in many inflammatory processes such as increased angiogenesis and DNA synthesis, genomic damage, cellular proliferation, disruption of DNA repair pathways, and inhibition of apoptosis. On this basis, the exploration of marine sources in search of novel chemical scaffolds for the treatment of inflammatory-driven diseases represents a key pharmacological goal.
As the Guest Editor, I would like to invite scientists to report their findings in the field of marine anti-inflammatory compounds.
Prof. Dr. Agostino Casapullo
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed Open Access monthly journal published by MDPI.
- marine natural products
- transcription factors
- drug discovery
- anti-inflammatory effects
- bioactive compounds
- marine pharmaceuticals
- autoimmune diseases
- intracellular signaling pathways
Article: Soft Coral-Derived Lemnalol Alleviates Monosodium Urate-Induced Gouty Arthritis in Rats by Inhibiting Leukocyte Infiltration and iNOS, COX-2 and c-Fos Protein Expression
Mar. Drugs 2013, 11(1), 99-113; doi:10.3390/md11010099
Received: 28 November 2012; in revised form: 21 December 2012 / Accepted: 26 December 2012 / Published: 10 January 2013| Download PDF Full-text (978 KB) | Download XML Full-text
Article: Differential in Gel Electrophoresis (DIGE) Comparative Proteomic Analysis of Macrophages Cell Cultures in Response to Perthamide C Treatment
Mar. Drugs 2013, 11(4), 1288-1299; doi:10.3390/md11041288
Received: 28 February 2013; in revised form: 19 March 2013 / Accepted: 1 April 2013 / Published: 17 April 2013| Download PDF Full-text (617 KB) | Download XML Full-text
Mar. Drugs 2013, 11(4), 1336-1350; doi:10.3390/md11041336
Received: 26 February 2013; in revised form: 22 March 2013 / Accepted: 27 March 2013 / Published: 22 April 2013| Download PDF Full-text (382 KB) | Download XML Full-text
Last update: 6 November 2012