Mar. Drugs 2013, 11(7), 2595-2615; doi:10.3390/md11072595
Article

Lithothamnion muelleri Controls Inflammatory Responses, Target Organ Injury and Lethality Associated with Graft-versus-Host Disease in Mice

1 Laboratory of Resolution of Inflammatory Response, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Brazil 2 Laboratory of Experimental Neuro-Immunopathology, Department of Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Brazil 3 Host-Microbes Interaction Laboratory, Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Brazil 4 Department of Pharmaceutical Products, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Brazil 5 Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Brazil These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 3 May 2013; in revised form: 1 July 2013 / Accepted: 2 July 2013 / Published: 18 July 2013
(This article belongs to the Special Issue Marine Compounds and Inflammation)
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Abstract: Lithothamnion muelleri (Hapalidiaceae) is a marine red alga, which is a member of a group of algae with anti-inflammatory, antitumor, and immunomodulatory properties. The present study evaluated the effects of treatment with Lithothamnion muelleri extract (LM) in a model of acute graft-versus-host disease (GVHD), using a model of adoptive splenocyte transfer from C57BL/6 donors into B6D2F1 recipient mice. Mice treated with LM showed reduced clinical signs of disease and mortality when compared with untreated mice. LM-treated mice had reduced tissue injury, less bacterial translocation, and decreased levels of proinflammatory cytokines and chemokines (interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), chemokine (C-C motif) ligand 2 (CCL2), chemokine (C-C motif) ligand 3 (CCL3) and chemokine (C-C motif) ligand 5 (CCL5)). The polysaccharide-rich fraction derived from LM could inhibit leukocyte rolling and adhesion in intestinal venules, as assessed by intravital microscopy. LM treatment did not impair the beneficial effects of graft-versus-leukaemia (GVL). Altogether, our studies suggest that treatment with Lithothamnion muelleri has a potential therapeutic application in GVHD treatment.
Keywords: algae; chemokine; cytokine; GVHD; inflammation

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MDPI and ACS Style

Rezende, B.M.; Bernardes, P.T.T.; Resende, C.B.; Arantes, R.M.E.; Souza, D.G.; Braga, F.C.; Castor, M.G.M.; Teixeira, M.M.; Pinho, V. Lithothamnion muelleri Controls Inflammatory Responses, Target Organ Injury and Lethality Associated with Graft-versus-Host Disease in Mice. Mar. Drugs 2013, 11, 2595-2615.

AMA Style

Rezende BM, Bernardes PTT, Resende CB, Arantes RME, Souza DG, Braga FC, Castor MGM, Teixeira MM, Pinho V. Lithothamnion muelleri Controls Inflammatory Responses, Target Organ Injury and Lethality Associated with Graft-versus-Host Disease in Mice. Marine Drugs. 2013; 11(7):2595-2615.

Chicago/Turabian Style

Rezende, Barbara M.; Bernardes, Priscila T.T.; Resende, Carolina B.; Arantes, Rosa M.E.; Souza, Danielle G.; Braga, Fernão C.; Castor, Marina G.M.; Teixeira, Mauro M.; Pinho, Vanessa. 2013. "Lithothamnion muelleri Controls Inflammatory Responses, Target Organ Injury and Lethality Associated with Graft-versus-Host Disease in Mice." Mar. Drugs 11, no. 7: 2595-2615.

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