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Mar. Drugs 2013, 11(6), 1853-1865; doi:10.3390/md11061853
Article

Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum

1
, 1
, 1,2,3
, 1,4
, 2,3,5
, 6
 and 1,4,7,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan 2 School of Pharmacy, China Medical University, Taichung 40402, Taiwan 3 Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan 4 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan 5 Center for Molecular Medicine, China Medical University Hospital, Taichung 40402, Taiwan 6 Institute of Oceanography, National Taiwan University, Taipei 10617, Taiwan 7 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
* Author to whom correspondence should be addressed.
Received: 20 March 2013 / Revised: 19 April 2013 / Accepted: 10 May 2013 / Published: 29 May 2013
(This article belongs to the Special Issue Marine Compounds and Inflammation)
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Abstract

Five new pregnane-type steroids, sclerosteroids J–N (15), and a diterpenoid with a new chemotype 3-methyl-5-(10′-acetoxy-2′,6′,10′-trimethylundecyl)-2-penten-5-olide (6), have been isolated from a soft coral Scleronephthya gracillimum. The structures of the metabolites were determined by extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against HepG2, A549, and MDA-MB-231 cancer cell lines. Furthermore, steroids 2 and 4 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein, and 1, 2, 4 and 5 could effectively reduce the accumulation of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.
Keywords: soft coral; Scleronephthya gracillimum; cytotoxicity activity; anti-inflammatory activity soft coral; Scleronephthya gracillimum; cytotoxicity activity; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Fang, H.-Y.; Hsu, C.-H.; Chao, C.-H.; Wen, Z.-H.; Wu, Y.-C.; Dai, C.-F.; Sheu, J.-H. Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum. Mar. Drugs 2013, 11, 1853-1865.

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