Mar. Drugs 2013, 11(6), 1853-1865; doi:10.3390/md11061853
Article

Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum

1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan 2 School of Pharmacy, China Medical University, Taichung 40402, Taiwan 3 Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan 4 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan 5 Center for Molecular Medicine, China Medical University Hospital, Taichung 40402, Taiwan 6 Institute of Oceanography, National Taiwan University, Taipei 10617, Taiwan 7 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
* Author to whom correspondence should be addressed.
Received: 20 March 2013; in revised form: 19 April 2013 / Accepted: 10 May 2013 / Published: 29 May 2013
(This article belongs to the Special Issue Marine Compounds and Inflammation)
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Abstract: Five new pregnane-type steroids, sclerosteroids J–N (15), and a diterpenoid with a new chemotype 3-methyl-5-(10′-acetoxy-2′,6′,10′-trimethylundecyl)-2-penten-5-olide (6), have been isolated from a soft coral Scleronephthya gracillimum. The structures of the metabolites were determined by extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against HepG2, A549, and MDA-MB-231 cancer cell lines. Furthermore, steroids 2 and 4 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein, and 1, 2, 4 and 5 could effectively reduce the accumulation of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.
Keywords: soft coral; Scleronephthya gracillimum; cytotoxicity activity; anti-inflammatory activity

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MDPI and ACS Style

Fang, H.-Y.; Hsu, C.-H.; Chao, C.-H.; Wen, Z.-H.; Wu, Y.-C.; Dai, C.-F.; Sheu, J.-H. Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum. Mar. Drugs 2013, 11, 1853-1865.

AMA Style

Fang H-Y, Hsu C-H, Chao C-H, Wen Z-H, Wu Y-C, Dai C-F, Sheu J-H. Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum. Marine Drugs. 2013; 11(6):1853-1865.

Chicago/Turabian Style

Fang, Hui-Yu; Hsu, Chi-Hsin; Chao, Chih-Hua; Wen, Zhi-Hong; Wu, Yang-Chang; Dai, Chang-Feng; Sheu, Jyh-Horng. 2013. "Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum." Mar. Drugs 11, no. 6: 1853-1865.

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