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Mar. Drugs 2013, 11(6), 1853-1865; doi:10.3390/md11061853

Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
2
School of Pharmacy, China Medical University, Taichung 40402, Taiwan
3
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan
4
Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
5
Center for Molecular Medicine, China Medical University Hospital, Taichung 40402, Taiwan
6
Institute of Oceanography, National Taiwan University, Taipei 10617, Taiwan
7
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
*
Author to whom correspondence should be addressed.
Received: 20 March 2013 / Revised: 19 April 2013 / Accepted: 10 May 2013 / Published: 29 May 2013
(This article belongs to the Special Issue Marine Compounds and Inflammation)
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Abstract

Five new pregnane-type steroids, sclerosteroids J–N (15), and a diterpenoid with a new chemotype 3-methyl-5-(10′-acetoxy-2′,6′,10′-trimethylundecyl)-2-penten-5-olide (6), have been isolated from a soft coral Scleronephthya gracillimum. The structures of the metabolites were determined by extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against HepG2, A549, and MDA-MB-231 cancer cell lines. Furthermore, steroids 2 and 4 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein, and 1, 2, 4 and 5 could effectively reduce the accumulation of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.
Keywords: soft coral; Scleronephthya gracillimum; cytotoxicity activity; anti-inflammatory activity soft coral; Scleronephthya gracillimum; cytotoxicity activity; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Fang, H.-Y.; Hsu, C.-H.; Chao, C.-H.; Wen, Z.-H.; Wu, Y.-C.; Dai, C.-F.; Sheu, J.-H. Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum. Mar. Drugs 2013, 11, 1853-1865.

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