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Mar. Drugs 2013, 11(6), 1853-1865; doi:10.3390/md11061853
Article

Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum

1
,
1
,
1,2,3
,
1,4
,
2,3,5
,
6
 and
1,4,7,*
Received: 20 March 2013 / Revised: 19 April 2013 / Accepted: 10 May 2013 / Published: 29 May 2013
(This article belongs to the Special Issue Marine Compounds and Inflammation)
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Abstract

Five new pregnane-type steroids, sclerosteroids J–N (15), and a diterpenoid with a new chemotype 3-methyl-5-(10′-acetoxy-2′,6′,10′-trimethylundecyl)-2-penten-5-olide (6), have been isolated from a soft coral Scleronephthya gracillimum. The structures of the metabolites were determined by extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against HepG2, A549, and MDA-MB-231 cancer cell lines. Furthermore, steroids 2 and 4 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein, and 1, 2, 4 and 5 could effectively reduce the accumulation of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.
Keywords: soft coral; Scleronephthya gracillimum; cytotoxicity activity; anti-inflammatory activity soft coral; Scleronephthya gracillimum; cytotoxicity activity; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fang, H.-Y.; Hsu, C.-H.; Chao, C.-H.; Wen, Z.-H.; Wu, Y.-C.; Dai, C.-F.; Sheu, J.-H. Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum. Mar. Drugs 2013, 11, 1853-1865.

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