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Anti-Inflammatory Components of the Starfish Astropecten polyacanthus
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi 10000, Vietnam
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea
School of Medicine, Brain Korea 21 Program, and Institute of Medical Science, Jeju National University, Jeju 690-756, Korea
* Author to whom correspondence should be addressed.
Received: 20 June 2013; in revised form: 17 July 2013 / Accepted: 19 July 2013 / Published: 13 August 2013
Abstract: Inflammation is important in biomedical research, because it plays a key role in inflammatory diseases including rheumatoid arthritis and other forms of arthritis, diabetes, heart disease, irritable bowel syndrome, Alzheimer’s disease, Parkinson’s disease, allergies, asthma, and even cancer. In the present study, we describe the inhibitory effect of crude extracts and steroids isolated from the starfish Astropecten polyacanthus on pro-inflammatory cytokine (Interleukin-12 (IL-12) p40, interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α)) production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs). Among those tested, compounds 5 and 7 showed potent inhibitory effects on the production of all three pro-inflammatory cytokines with IC50 values ranging from 1.82 ± 0.11 to 7.00 ± 0.16 μM. Potent inhibitory activities were also observed for compound 1 on the production of IL-12 p40 and IL-6 with values of 3.96 ± 0.12 and 4.07 ± 0.13 μM, respectively, and for compounds 3 and 4 on the production of IL-12 p40 with values of 6.55 ± 0.18 and 5.06 ± 0.16 μM, respectively. Moreover, compounds 2 (IC50 = 34.86 ± 0.31 μM) and 6 (IC50 = 79.05 ± 2.05 μM) exhibited moderate inhibitory effects on the production of IL-12 p40, whereas compounds 3 (IC50 = 22.80 ± 0.21 μM) and 4 (IC50 = 16.73 ± 0.25 μM) moderately inhibited the production of TNF-α and IL-6, respectively.
Keywords: starfish; Astropecten polyacanthus; IL-12 p40; IL-6; TNF-α; LPS-stimulated BMDCs
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Thao, N.P.; Cuong, N.X.; Luyen, B.T.T.; Quang, T.H.; Hanh, T.T.H.; Kim, S.; Koh, Y.-S.; Nam, N.H.; Van Kiem, P.; Van Minh, C.; Kim, Y.H. Anti-Inflammatory Components of the Starfish Astropecten polyacanthus. Mar. Drugs 2013, 11, 2917-2926.
Thao NP, Cuong NX, Luyen BTT, Quang TH, Hanh TTH, Kim S, Koh Y-S, Nam NH, Van Kiem P, Van Minh C, Kim YH. Anti-Inflammatory Components of the Starfish Astropecten polyacanthus. Marine Drugs. 2013; 11(8):2917-2926.
Thao, Nguyen P.; Cuong, Nguyen X.; Luyen, Bui T.T.; Quang, Tran H.; Hanh, Tran T.H.; Kim, Sohyun; Koh, Young-Sang; Nam, Nguyen H.; Van Kiem, Phan; Van Minh, Chau; Kim, Young H. 2013. "Anti-Inflammatory Components of the Starfish Astropecten polyacanthus." Mar. Drugs 11, no. 8: 2917-2926.