Next Article in Journal
Marinopyrrole Derivatives as Potential Antibiotic Agents against Methicillin-Resistant Staphylococcus aureus (II)
Next Article in Special Issue
Functional Metabolomics Uncovers Metabolic Alterations Associated to Severe Oxidative Stress in MCF7 Breast Cancer Cells Exposed to Ascididemin
Previous Article in Journal
Development of Synechocystis sp. PCC 6803 as a Phototrophic Cell Factory
Previous Article in Special Issue
Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2013, 11(8), 2917-2926; doi:10.3390/md11082917

Anti-Inflammatory Components of the Starfish Astropecten polyacanthus

Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi 10000, Vietnam
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea
School of Medicine, Brain Korea 21 Program, and Institute of Medical Science, Jeju National University, Jeju 690-756, Korea
Author to whom correspondence should be addressed.
Received: 20 June 2013 / Revised: 17 July 2013 / Accepted: 19 July 2013 / Published: 13 August 2013
(This article belongs to the Special Issue Marine Compounds and Inflammation)
View Full-Text   |   Download PDF [503 KB, uploaded 24 February 2015]   |  


Inflammation is important in biomedical research, because it plays a key role in inflammatory diseases including rheumatoid arthritis and other forms of arthritis, diabetes, heart disease, irritable bowel syndrome, Alzheimer’s disease, Parkinson’s disease, allergies, asthma, and even cancer. In the present study, we describe the inhibitory effect of crude extracts and steroids isolated from the starfish Astropecten polyacanthus on pro-inflammatory cytokine (Interleukin-12 (IL-12) p40, interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α)) production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs). Among those tested, compounds 5 and 7 showed potent inhibitory effects on the production of all three pro-inflammatory cytokines with IC50 values ranging from 1.82 ± 0.11 to 7.00 ± 0.16 μM. Potent inhibitory activities were also observed for compound 1 on the production of IL-12 p40 and IL-6 with values of 3.96 ± 0.12 and 4.07 ± 0.13 μM, respectively, and for compounds 3 and 4 on the production of IL-12 p40 with values of 6.55 ± 0.18 and 5.06 ± 0.16 μM, respectively. Moreover, compounds 2 (IC50 = 34.86 ± 0.31 μM) and 6 (IC50 = 79.05 ± 2.05 μM) exhibited moderate inhibitory effects on the production of IL-12 p40, whereas compounds 3 (IC50 = 22.80 ± 0.21 μM) and 4 (IC50 = 16.73 ± 0.25 μM) moderately inhibited the production of TNF-α and IL-6, respectively.
Keywords: starfish; Astropecten polyacanthus; IL-12 p40; IL-6; TNF-α; LPS-stimulated BMDCs starfish; Astropecten polyacanthus; IL-12 p40; IL-6; TNF-α; LPS-stimulated BMDCs

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary materials

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Thao, N.P.; Cuong, N.X.; Luyen, B.T.T.; Quang, T.H.; Hanh, T.T.H.; Kim, S.; Koh, Y.-S.; Nam, N.H.; Van Kiem, P.; Van Minh, C.; Kim, Y.H. Anti-Inflammatory Components of the Starfish Astropecten polyacanthus. Mar. Drugs 2013, 11, 2917-2926.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top