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Mar. Drugs 2013, 11(8), 2741-2750; doi:10.3390/md11082741
Article

Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

1
,
1
,
2
 and
1,3,4,5,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan 2 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 33302, Taiwan 3 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan 4 Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan 5 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
* Author to whom correspondence should be addressed.
Received: 17 June 2013 / Revised: 9 July 2013 / Accepted: 11 July 2013 / Published: 2 August 2013
(This article belongs to the Special Issue Marine Compounds and Inflammation)
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Abstract

New four eunicellin-based diterpenoids, krempfielins J–M (14) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. The structure of compound 2 is rare due to the presence of the highly oxygenated pattern. Anti-inflammatory activity of 16 to inhibit the superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils was also evaluated, and 2 and 4 were shown to possess the ability to inhibit the elastase release.
Keywords: Cladiella krempfi; eunicellin-based diterpenoid; elastase; anti-inflammatory agent Cladiella krempfi; eunicellin-based diterpenoid; elastase; anti-inflammatory agent
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lee, Y.-N.; Tai, C.-J.; Hwang, T.-L.; Sheu, J.-H. Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi. Mar. Drugs 2013, 11, 2741-2750.

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