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Mar. Drugs 2013, 11(8), 2741-2750; doi:10.3390/md11082741
Article

Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

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1,3,4,5,*
Received: 17 June 2013 / Revised: 9 July 2013 / Accepted: 11 July 2013 / Published: 2 August 2013
(This article belongs to the Special Issue Marine Compounds and Inflammation)
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Abstract

New four eunicellin-based diterpenoids, krempfielins J–M (14) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. The structure of compound 2 is rare due to the presence of the highly oxygenated pattern. Anti-inflammatory activity of 16 to inhibit the superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils was also evaluated, and 2 and 4 were shown to possess the ability to inhibit the elastase release.
Keywords: Cladiella krempfi; eunicellin-based diterpenoid; elastase; anti-inflammatory agent Cladiella krempfi; eunicellin-based diterpenoid; elastase; anti-inflammatory agent
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lee, Y.-N.; Tai, C.-J.; Hwang, T.-L.; Sheu, J.-H. Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi. Mar. Drugs 2013, 11, 2741-2750.

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