Mar. Drugs 2013, 11(8), 2741-2750; doi:10.3390/md11082741
Article

Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan 2 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 33302, Taiwan 3 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan 4 Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan 5 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
* Author to whom correspondence should be addressed.
Received: 17 June 2013; in revised form: 9 July 2013 / Accepted: 11 July 2013 / Published: 2 August 2013
(This article belongs to the Special Issue Marine Compounds and Inflammation)
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Abstract: New four eunicellin-based diterpenoids, krempfielins J–M (14) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. The structure of compound 2 is rare due to the presence of the highly oxygenated pattern. Anti-inflammatory activity of 16 to inhibit the superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils was also evaluated, and 2 and 4 were shown to possess the ability to inhibit the elastase release.
Keywords: Cladiella krempfi; eunicellin-based diterpenoid; elastase; anti-inflammatory agent

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MDPI and ACS Style

Lee, Y.-N.; Tai, C.-J.; Hwang, T.-L.; Sheu, J.-H. Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi. Mar. Drugs 2013, 11, 2741-2750.

AMA Style

Lee Y-N, Tai C-J, Hwang T-L, Sheu J-H. Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi. Marine Drugs. 2013; 11(8):2741-2750.

Chicago/Turabian Style

Lee, Yan-Ning; Tai, Chi-Jen; Hwang, Tsong-Long; Sheu, Jyh-Horng. 2013. "Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi." Mar. Drugs 11, no. 8: 2741-2750.

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