Special Issue "Blood Substitutes"

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A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (30 November 2014)

Special Issue Editor

Guest Editor
Prof. Dr. Ken Olsen
Department of Chemistry, Loyola University of Chicago, 1032 W. Sheridan Rd., Chicago, IL 60660, USA
Website: http://www.luc.edu/chemistry/facultystaff/faculty_olsen.shtml
E-Mail: kolsen@luc.edu
Interests: the development of polymeric hemoglobins as potential blood substitutes; developing cancer-targeted photodynamic therapy agents; understanding protein-ligand interactions through molecular dynamics simulations

Special Issue Information

Dear Colleagues,

The development of hemoglobin-based oxygen carriers (HBOC) as effective alternatives to blood transfusion is clearly a desirable goal. Despite the significant commercial resources that have been expended over the last several decades to achieve this end, no products have received US FDA approval. The basic science is much better understood than it was in the 1980s when the quest began. The requirements for a successful HBOC have been clearly delineated. Various side effects have inhibited further development and regulatory approval. Cardiovascular events are of particular concern, but other aspects needing investigation include the impact of HBOCs on human physiology, the routes and consequences of hemoglobin metabolism and developing new HBOCs with improved characteristics, such as prolonged functional intravascular persistence, greater stability, and a decreased propensity to generate reactive oxygen species. New biomaterials are being developed to address these problems encountered with earlier HBOCs. In some cases these are not hemoglobin-based, but may offer new solutions to the same problems faced by the HBOCs.

Prof. Dr. Ken Olsen
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


Published Papers (6 papers)

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Displaying article 1-6
p. 288-295
by ,  and
J. Funct. Biomater. 2014, 5(4), 288-295; doi:10.3390/jfb5040288
Received: 24 August 2014; in revised form: 19 November 2014 / Accepted: 25 November 2014 / Published: 12 December 2014
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(This article belongs to the Special Issue Blood Substitutes)
p. 246-258
by , , , , , , , ,  and
J. Funct. Biomater. 2014, 5(4), 246-258; doi:10.3390/jfb5040246
Received: 17 September 2014; in revised form: 7 November 2014 / Accepted: 12 November 2014 / Published: 18 November 2014
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(This article belongs to the Special Issue Blood Substitutes)
p. 232-245
by , , , , , ,  and
J. Funct. Biomater. 2014, 5(4), 232-245; doi:10.3390/jfb5040232
Received: 13 August 2014; in revised form: 17 September 2014 / Accepted: 15 October 2014 / Published: 27 October 2014
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(This article belongs to the Special Issue Blood Substitutes)
p. 61-78
by , , , , ,  and
J. Funct. Biomater. 2012, 3(1), 61-78; doi:10.3390/jfb3010061
Received: 3 November 2011; in revised form: 29 December 2011 / Accepted: 5 January 2012 / Published: 13 January 2012
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(This article belongs to the Special Issue Blood Substitutes)
p. 49-60
by  and
J. Funct. Biomater. 2012, 3(1), 49-60; doi:10.3390/jfb3010049
Received: 21 October 2011; in revised form: 9 December 2011 / Accepted: 24 December 2011 / Published: 6 January 2012
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(This article belongs to the Special Issue Blood Substitutes)
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p. 414-424
by  and
J. Funct. Biomater. 2011, 2(4), 414-424; doi:10.3390/jfb2040414
Received: 3 November 2011; in revised form: 3 December 2011 / Accepted: 13 December 2011 / Published: 16 December 2011
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Last update: 4 December 2014

J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert