Special Issue "Blood Substitutes"
A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).
Deadline for manuscript submissions: closed (30 November 2014)
Prof. Dr. Ken Olsen
Department of Chemistry, Loyola University of Chicago, 1032 W. Sheridan Rd., Chicago, IL 60660, USA
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Interests: the development of polymeric hemoglobins as potential blood substitutes; developing cancer-targeted photodynamic therapy agents; understanding protein-ligand interactions through molecular dynamics simulations
The development of hemoglobin-based oxygen carriers (HBOC) as effective alternatives to blood transfusion is clearly a desirable goal. Despite the significant commercial resources that have been expended over the last several decades to achieve this end, no products have received US FDA approval. The basic science is much better understood than it was in the 1980s when the quest began. The requirements for a successful HBOC have been clearly delineated. Various side effects have inhibited further development and regulatory approval. Cardiovascular events are of particular concern, but other aspects needing investigation include the impact of HBOCs on human physiology, the routes and consequences of hemoglobin metabolism and developing new HBOCs with improved characteristics, such as prolonged functional intravascular persistence, greater stability, and a decreased propensity to generate reactive oxygen species. New biomaterials are being developed to address these problems encountered with earlier HBOCs. In some cases these are not hemoglobin-based, but may offer new solutions to the same problems faced by the HBOCs.
Prof. Dr. Ken Olsen
Manuscript Submission Information
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