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J. Funct. Biomater. 2011, 2(4), 414-424; doi:10.3390/jfb2040414
Review

Molecular Design Properties of OxyVita Hemoglobin, a New Generation Therapeutic Oxygen Carrier: A Review

1,2,*  and 2
Received: 3 November 2011 / Revised: 3 December 2011 / Accepted: 13 December 2011 / Published: 16 December 2011
(This article belongs to the Special Issue Blood Substitutes)
View Full-Text   |   Download PDF [269 KB, 19 December 2011; original version 16 December 2011]   |   Browse Figures

Abstract

OxyVita Hb is a new generation hemoglobin based oxygen carrier (HBOC) produced through modification of a zero-linked polymerization mechanism using activators which incorporate cross-linked bovine tetramer hemoglobin into “super-polymeric” macromolecules (Average molecular weight = 17 MDa) for the purpose of oxygen delivery when whole blood or packed red cells are not available. This molecular design approach was generated in order to address several fundamental biochemical and physiological weaknesses of previous generations of HBOCs. Observation during pre-clinical and clinical studies provided evidence that these early generation acellular HBOCs were directly associated with loss of retention within the circulatory system, extravasation across endothelial tissue membranes due to their small molecular size leading to arterial and venous vasoconstriction with coupled increases in mean arterial pressure (MAP). The inherent increase in molecular size and structural stability of the OxyVita Hb is a direct response to addressing these serious weaknesses that have occurred during the evolution of HBOC development within the past two decades. The nature of the zero-linked synthetic route eliminates any chemical linkers remaining in the product, eliminating side reaction concerns, such as reversibility and decomposition due to weak chemical bonds, dependency on temperature and pressure, and residual toxicity.
Keywords: acellular hemoglobin; zero-linked polymerization; hemoglobin-based-oxygen-carrier (hboc) acellular hemoglobin; zero-linked polymerization; hemoglobin-based-oxygen-carrier (hboc)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Harrington, J.P.; Wollocko, H. Molecular Design Properties of OxyVita Hemoglobin, a New Generation Therapeutic Oxygen Carrier: A Review. J. Funct. Biomater. 2011, 2, 414-424.

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