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Molecular Design Properties of OxyVita Hemoglobin, a New Generation Therapeutic Oxygen Carrier: A Review
Department of Chemistry, State University of New York, New Paltz, NY 12561, USA
OXYVITA, Inc., New Windsor, NY 12553, USA
* Author to whom correspondence should be addressed.
Received: 3 November 2011; in revised form: 3 December 2011 / Accepted: 13 December 2011 / Published: 16 December 2011
Abstract: OxyVita Hb is a new generation hemoglobin based oxygen carrier (HBOC) produced through modification of a zero-linked polymerization mechanism using activators which incorporate cross-linked bovine tetramer hemoglobin into “super-polymeric” macromolecules (Average molecular weight = 17 MDa) for the purpose of oxygen delivery when whole blood or packed red cells are not available. This molecular design approach was generated in order to address several fundamental biochemical and physiological weaknesses of previous generations of HBOCs. Observation during pre-clinical and clinical studies provided evidence that these early generation acellular HBOCs were directly associated with loss of retention within the circulatory system, extravasation across endothelial tissue membranes due to their small molecular size leading to arterial and venous vasoconstriction with coupled increases in mean arterial pressure (MAP). The inherent increase in molecular size and structural stability of the OxyVita Hb is a direct response to addressing these serious weaknesses that have occurred during the evolution of HBOC development within the past two decades. The nature of the zero-linked synthetic route eliminates any chemical linkers remaining in the product, eliminating side reaction concerns, such as reversibility and decomposition due to weak chemical bonds, dependency on temperature and pressure, and residual toxicity.
Keywords: acellular hemoglobin; zero-linked polymerization; hemoglobin-based-oxygen-carrier (hboc)
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Harrington, J.P.; Wollocko, H. Molecular Design Properties of OxyVita Hemoglobin, a New Generation Therapeutic Oxygen Carrier: A Review. J. Funct. Biomater. 2011, 2, 414-424.
Harrington JP, Wollocko H. Molecular Design Properties of OxyVita Hemoglobin, a New Generation Therapeutic Oxygen Carrier: A Review. Journal of Functional Biomaterials. 2011; 2(4):414-424.
Harrington, John P.; Wollocko, Hanna. 2011. "Molecular Design Properties of OxyVita Hemoglobin, a New Generation Therapeutic Oxygen Carrier: A Review." J. Funct. Biomater. 2, no. 4: 414-424.