J. Funct. Biomater. 2012, 3(1), 49-60; doi:10.3390/jfb3010049
Review

Biophysical Properties of Lumbricus terrestris Erythrocruorin and Its Potential Use as a Red Blood Cell Substitute

William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 425 Koffolt Laboratories, 140 West 19th Avenue, Columbus, OH 43210, USA
* Author to whom correspondence should be addressed.
Received: 21 October 2011; in revised form: 9 December 2011 / Accepted: 24 December 2011 / Published: 6 January 2012
(This article belongs to the Special Issue Blood Substitutes)
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Abstract: Previous generations of hemoglobin (Hb)-based oxygen carriers (HBOCs) have been plagued by key biophysical limitations that result in severe side-effects once transfused in vivo, including protein instability, high heme oxidation rates, and nitric oxide (NO) scavenging. All of these problems emerge after mammalian Hbs are removed from red blood cells (RBCs) and used for HBOC synthesis/formulation. Therefore, extracellular Hbs (erythrocruorins) from organisms which lack RBCs might serve as better HBOCs. This review focuses on the erythrocruorin of Lumbricus terrestris (LtEc), which has been shown to be extremely stable, resistant to oxidation, and may interact with NO differently than mammalian Hbs. All of these beneficial properties show that LtEc is a promising new HBOC which warrants further investigation.
Keywords: red blood cell substitute; hemoglobin; erythrocruorin; oxygen carrier

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MDPI and ACS Style

Elmer, J.; Palmer, A.F. Biophysical Properties of Lumbricus terrestris Erythrocruorin and Its Potential Use as a Red Blood Cell Substitute. J. Funct. Biomater. 2012, 3, 49-60.

AMA Style

Elmer J, Palmer AF. Biophysical Properties of Lumbricus terrestris Erythrocruorin and Its Potential Use as a Red Blood Cell Substitute. Journal of Functional Biomaterials. 2012; 3(1):49-60.

Chicago/Turabian Style

Elmer, Jacob; Palmer, Andre F. 2012. "Biophysical Properties of Lumbricus terrestris Erythrocruorin and Its Potential Use as a Red Blood Cell Substitute." J. Funct. Biomater. 3, no. 1: 49-60.

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