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J. Funct. Biomater. 2014, 5(4), 246-258; doi:10.3390/jfb5040246

Effects of the Oxygen-Carrying Solution OxyVita C on the Cerebral Microcirculation and Systemic Blood Pressures in Healthy Rats

1
NeuroTrauma Department, Naval Medical Research Center (NMRC), Silver Spring, MD 20910, USA
2
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20895, USA
*
Author to whom correspondence should be addressed.
Received: 17 September 2014 / Revised: 7 November 2014 / Accepted: 12 November 2014 / Published: 18 November 2014
(This article belongs to the Special Issue Blood Substitutes)
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Abstract

The use of hemoglobin-based oxygen carriers (HBOC) as oxygen delivering therapies during hypoxic states has been hindered by vasoconstrictive side effects caused by depletion of nitric oxide (NO). OxyVita C is a promising oxygen-carrying solution that consists of a zero-linked hemoglobin polymer with a high molecular weight (~17 MDa). The large molecular weight is believed to prevent extravasation and limit NO scavenging and vasoconstriction. The aim of this study was to assess vasoactive effects of OxyVita C on systemic blood pressures and cerebral pial arteriole diameters. Anesthetized healthy rats received four intravenous (IV) infusions of an increasing dose of OxyVita C (2, 25, 50, 100 mg/kg) and hemodynamic parameters and pial arteriolar diameters were measured pre- and post-infusion. Normal saline was used as a volume-matched control. Systemic blood pressures increased (P ≤ 0.05) with increasing doses of OxyVita C, but not with saline. There was no vasoconstriction in small (<50 µm) and medium-sized (50–100 µm) pial arterioles in the OxyVita C group. In contrast, small and medium-sized pial arterioles vasoconstricted in the control group. Compared to saline, OxyVita C showed no cerebral vasoconstriction after any of the four doses evaluated in this rat model despite increases in blood pressure. View Full-Text
Keywords: cerebral microcirculation; hemoglobin-based oxygen carriers (HBOC); oxygen therapeutic; vasoconstriction; intravital microscopy cerebral microcirculation; hemoglobin-based oxygen carriers (HBOC); oxygen therapeutic; vasoconstriction; intravital microscopy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Abutarboush, R.; Aligbe, C.; Pappas, G.; Saha, B.; Arnaud, F.; Haque, A.; Auker, C.; McCarron, R.; Scultetus, A.; Moon-Massat, P. Effects of the Oxygen-Carrying Solution OxyVita C on the Cerebral Microcirculation and Systemic Blood Pressures in Healthy Rats. J. Funct. Biomater. 2014, 5, 246-258.

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J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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