Special Issue "Coating Deposition and Surface Functionalization of Implants for Biomedical Applications 2014"
A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).
Deadline for manuscript submissions: closed (30 June 2014)
Dr. Antonella Sola
Department of Engineering "Enzo Ferrari" University of Modena and Reggio Via Vignolese 905 - 41125 Modena, Italy
Phone: +39 059 2056233
Fax: +39 059 2056243
Interests: biomaterials; bioceramics; bioactive glasses; bioactive coatings; porous materials; scaffolds; glasses; ceramics; composite materials; functional coatings; sintering and thermal treatments
The human body is able to promote spontaneous healing phenomena to face the adverse consequences of diseases, aging processes or traumatic events. However such natural reactions are not always sufficient to recover extensive functional losses and, in that case, medical or surgical interventions are required. For this reason, the demand for new biomaterials to support or restore the role of damaged tissues is a major clinical and socioeconomic need. The deposition of a proper coating or the chemicophysical treatment of the surface may boost the performance of implant devices, conveying site-specific properties to the substrate material. The apposition of glass-based glazes which resemble the original enamel of tooth, the chemical modification of titanium to activate the bone-bonding ability or the deposition of calcium-phosphate layers on metal substrates to elicit the surface development of hydroxyapatite a re just a few examples of the new approaches to improve the behaviour of medical grafts by means of biocoatings and surface functionalization methods.
Dr. Antonella Sola
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- surface treatments
- coating deposition methods
- implant materials
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Article
Title: Implanting MgO into the Bone Marrow Cavity Increases the Bone Mass of Rat
Author: Tibia Håkan Nygren
Affiliation: Dept of Biomedicine, University of Gothenburgh, Göteborg, Sweden
Abstract: In 1924, Arthur A. Zierold published a study “with the object to determine whether metal per se, when implanted in bone, exerts an influence other than that of any foreign body”. The study included a large number of dogs, and the analysis of the outcome was made by x-ray and histology. The results show that the healing of bone at metal implants resembles normal fracture healing of bone in that a callus of immature, woven bone is formed below the periosteum and endosteum. The amount of callus bone was found to vary with the implanted metals and was interpreted as the result of successful healing. The possibility of remodeling as a cause of variation in the amount of callus-bone, was not considered at the time. Implanted Mg was shown to increase the amount of connective tissue and callus-bone formed under the periosteum, but the lesion did not heal, and new bone was not seen in contact with the implant. These data were later confirmed by McBride. Thus, Zierold reports that Mg-implants are resorbed by bone tissue and has both retarding and stimulating effect on the formation of bone during healing. The similarity between bone fracture healing and bone healing at implants was further studied by us some years ago. In rat tibia, callus bone was seen already at 4 days after injury, and remodeling of the callus was seen in the second week after injury. A thin layer of bone, at the titanium surface was resisting resorption, but in the sham operated rats the entire marrow cavity was cleared from callus bone during remodeling. The bone cover of titanium implants is present after 2 years. Some attempts have been made to exploit the effect of Mg upon implant healing by using porous titanium implants covered with Mg. After 4 weeks of implantation, more mineralized bone was found surrounding Mg-coated implants than around porous titanium implants. An increasing interest in Mg as a resorbable implant material is seen in recent years and several studies have been published on the effects of Mg on bone healing. The results of these studies indicate that implanted Mg induces an increase in the amount of bone surrounding the implants, but the difference between callus bone and mature bone is given little attention. In the present study, the effect of MgO on the healing of a drilled hole in bone is followed over 3 weeks of implantation. The effect of MgO on the pattern of osteocyte apoptosis is studied in an attempt to elucidate the mechanism behind the effect of Mg on bone healing. The results of the present study show that the observations made by Zierold 90 years ago can be reproduced, new interpretations of the results can be made by studying bone apoptosis, and new effects have been found on the long term effects of Mg on bone.
Last update: 13 May 2014