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J. Funct. Biomater. 2014, 5(3), 158-166; doi:10.3390/jfb5030158

Increase of Compact Bone Thickness in Rat Tibia after Implanting MgO into the Bone Marrow Cavity

1
Department of Cell Biology and Medical Chemistry, Institute of Biomedicine, University of Gothenburg, P.O. Box 420, 405 30 Göteborg, Sweden
2
Department of Applied Physics, Chalmers University of Technology, 412 96 Göteborg, Sweden
3
Department of Oral and Maxillofacial Surgery, Institute of Odontology, University of Gothenburg, P.O. Box 450, 405 30 Göteborg, Sweden
4
National Center of Imaging Mass Spetrometry, Chalmers University of Technology, 412 96 Göteborg, Sweden
5
Elos Medtech, 540 16 Timmersdala, Sweden
*
Author to whom correspondence should be addressed.
Received: 7 July 2014 / Revised: 13 August 2014 / Accepted: 4 September 2014 / Published: 11 September 2014
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Abstract

The effect of implanting MgO paste into the bone marrow of rat tibia, was studied by light microscopy, time of flight-secondary ion mass spectrometry (ToF-SIMS), and environmental scanning electron microscopy (ESEM), and energy dispersive X-ray (EDX) analysis. After three weeks of implantation, the thickness of compact bone increased by 25% compared to sham-operated controls, while no effect was seen on the trabecular bone. In order to further elucidate the mechanism of the Mg-induced increase in bone mass, EDX and ToF-SIMS analysis of the bone samples was made at two weeks. At this time-point, no detectable difference in the thickness of the compact bone in Mg-treated and non-treated animals was observed. The Mg-content of the bone marrow and bone tissue of the Mg-exposed animals did not differ from that of sham-operated controls, implying that there are no traces of the implanted MgO when the mass of compact bone increases, between two and three weeks after surgery. The ratio of Mg/Ca content was higher in the bone of Mg-treated animals, indicating an altered structure of the bone mineral, which was confirmed by the ToF-SIMS analysis, showing increased levels of MgCO3, phosphate ions and CaF in the bone of MgO-exposed animals. Possible cellular activities behind the effect of MgO on compact bone thickness are discussed. View Full-Text
Keywords: rat model; bone density; bone healing; bone remodeling; magnesium-oxide; ToF-SIMS; EDX rat model; bone density; bone healing; bone remodeling; magnesium-oxide; ToF-SIMS; EDX
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Nygren, H.; Chaudhry, M.; Gustafsson, S.; Kjeller, G.; Malmberg, P.; Johansson, K.-E. Increase of Compact Bone Thickness in Rat Tibia after Implanting MgO into the Bone Marrow Cavity. J. Funct. Biomater. 2014, 5, 158-166.

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J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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